Metagenome Analysis Exploiting High-Throughput Chromosome Conformation Capture (3C) Data.

Abstract : Microbial communities are complex and constitute important parts of our environment. Genomic analysis of these populations is a dynamic research area but remains limited by the difficulty in assembling full genomes of individual species. Recently, a new method for metagenome assembly/analysis based on chromosome conformation capture has emerged (meta3C). This approach quantifies the collisions experienced by DNA molecules to identify those sharing the same cellular compartments, allowing the characterization of genomes present within complex mixes of species. The exploitation of these chromosome 3D signatures holds promising perspectives for genome sequencing of discrete species in complex populations. It also has the potential to assign correctly extra-chromosomal elements, such as plasmids, mobile elements and phages, to their host cells.
Document type :
Journal articles
Complete list of metadatas

Cited literature [55 references]  Display  Hide  Download

https://hal-pasteur.archives-ouvertes.fr/pasteur-01419974
Contributor : Romain Koszul <>
Submitted on : Monday, April 24, 2017 - 2:33:23 PM
Last modification on : Thursday, January 11, 2018 - 6:25:25 AM
Long-term archiving on : Tuesday, July 25, 2017 - 4:15:08 PM

File

Marbouty et al non format.pdf
Files produced by the author(s)

Licence


Distributed under a Creative Commons Attribution - NonCommercial - ShareAlike 4.0 International License

Identifiers

Collections

Citation

Martial Marbouty, Romain Koszul. Metagenome Analysis Exploiting High-Throughput Chromosome Conformation Capture (3C) Data.. Trends in Genetics, Elsevier, 2015, 31 (12), pp.673-82. ⟨10.1016/j.tig.2015.10.003⟩. ⟨pasteur-01419974⟩

Share

Metrics

Record views

398

Files downloads

447