Allelic variation contributes to bacterial host specificity.

Abstract : Understanding the molecular parameters that regulate cross-species transmission and host adaptation of potential pathogens is crucial to control emerging infectious disease. Although microbial pathotype diversity is conventionally associated with gene gain or loss, the role of pathoadaptive nonsynonymous single-nucleotide polymorphisms (nsSNPs) has not been systematically evaluated. Here, our genome-wide analysis of core genes within Salmonella enterica serovar Typhimurium genomes reveals a high degree of allelic variation in surface-exposed molecules, including adhesins that promote host colonization. Subsequent multinomial logistic regression, MultiPhen and Random Forest analyses of known/suspected adhesins from 580 independent Typhimurium isolates identifies distinct host-specific nsSNP signatures. Moreover, population and functional analyses of host-associated nsSNPs for FimH, the type 1 fimbrial adhesin, highlights the role of key allelic residues in host-specific adherence in vitro. Together, our data provide the first concrete evidence that functional differences between allelic variants of bacterial proteins likely contribute to pathoadaption to diverse hosts.
Type de document :
Article dans une revue
Nature Communications, Nature Publishing Group, 2015, 6 (6), pp.8754. 〈10.1038/ncomms9754〉
Liste complète des métadonnées

Littérature citée [59 références]  Voir  Masquer  Télécharger

https://hal-pasteur.archives-ouvertes.fr/pasteur-01419902
Contributeur : Marie Lemesle <>
Soumis le : mardi 20 décembre 2016 - 10:24:22
Dernière modification le : mercredi 22 février 2017 - 01:02:20
Document(s) archivé(s) le : mardi 21 mars 2017 - 13:42:19

Fichier

Allelic variation.pdf
Publication financée par une institution

Licence


Copyright (Tous droits réservés)

Identifiants

Collections

Citation

Min Yue, Xiangan Han, Leon De Masi, Chunhong Zhu, Xun Ma, et al.. Allelic variation contributes to bacterial host specificity.. Nature Communications, Nature Publishing Group, 2015, 6 (6), pp.8754. 〈10.1038/ncomms9754〉. 〈pasteur-01419902〉

Partager

Métriques

Consultations de la notice

30

Téléchargements de fichiers

104