R. Hazra, G. K. Siberry, and L. M. Mofenson, Growing Up with HIV: Children, Adolescents, and Young Adults with Perinatally Acquired HIV Infection, Annual Review of Medicine, vol.61, issue.1, pp.169-185, 2010.
DOI : 10.1146/annurev.med.050108.151127

L. M. Mofenson, J. Oleske, L. Serchuck, R. Van-dyke, and C. Wilfert, Treating Opportunistic Infections among HIV-Exposed and Infected Children: Recommendations from CDC, the National Institutes of Health, and the Infectious Diseases Society of America, Clinical Infectious Diseases, vol.40, issue.Supplement 1, pp.1-84, 2005.
DOI : 10.1086/427295

C. G. Sutcliffe and W. J. Moss, Do children infected with HIV receiving HAART need to be revaccinated? Lancet Inf Dis, pp.630-642, 2010.
DOI : 10.1016/s1473-3099(10)70116-x

A. Marchant and M. Goldman, T cell-mediated immune responses in human newborns: ready to learn?, Clinical and Experimental Immunology, vol.166, issue.1, pp.10-18, 2005.
DOI : 10.1093/intimm/dxg123

C. Dollfus, J. L. Chenadec, and A. Faye, Long-term outcomes in adolescents perinatally infected with HIV-1 and followed up since birth in the French Perinatal Cohort (EPF/ANRS CO10) Clin Inf Dis, pp.214-224, 2010.

S. R. Lewin and C. Rouzioux, HIV cure and eradication: how will we get from the laboratory to effective clinical trials?, AIDS, vol.25, issue.7, pp.885-897, 2011.
DOI : 10.1097/QAD.0b013e3283467041

C. Rouzioux, J. B. Hubert, and M. Burgard, T Cell Counts, The Journal of Infectious Diseases, vol.192, issue.1, pp.46-55, 2005.
DOI : 10.1086/430610

URL : https://hal.archives-ouvertes.fr/pasteur-01420524

L. G. Kostrikis, G. Touloumi, and R. Karanicolas, Quantitation of human immunodeficiency virus type 1 DNA forms with the second template switch in peripheral JIDMS#48399R2_clean

D. V. Havlir, K. K. Koelsch, and M. C. Strain, Predictors of Residual Viremia in HIV???Infected Patients Successfully Treated with Efavirenz and Lamivudine plus either Tenofovir or Stavudine, The Journal of Infectious Diseases, vol.191, issue.7, pp.1164-1168, 2005.
DOI : 10.1086/428588

B. Hoen, D. A. Cooper, and F. C. Lampe, Predictors of Virological Outcome and Safety in Primary HIV Type 1-Infected Patients Initiating Quadruple Antiretroviral Therapy: QUEST GW PROB3005, Clinical Infectious Diseases, vol.45, issue.3, pp.381-390, 2007.
DOI : 10.1086/519428

URL : https://hal.archives-ouvertes.fr/hal-00465353

S. R. Ostrowski, T. L. Katzenstein, and P. T. Thim, Low???Level Viremia and Proviral DNA Impede Immune Reconstitution in HIV???1???Infected Patients Receiving Highly Active Antiretroviral Therapy, The Journal of Infectious Diseases, vol.191, issue.3, pp.348-357, 2005.
DOI : 10.1086/427340

URL : http://jid.oxfordjournals.org/cgi/content/short/191/3/348

G. Marchetti, A. Gori, and A. Casabianca, Comparative analysis of T-cell turnover and homeostatic parameters in HIV-infected patients with discordant immune-virological responses to HAART, AIDS, vol.20, issue.13, pp.1727-1736, 2006.
DOI : 10.1097/01.aids.0000242819.72839.db

S. Sei, D. P. O-'neill, and S. K. Stewart, Increased level of stromal cell-derived factor- 1 mRNA in peripheral blood mononuclear cells from children with AIDS-related lymphoma Longitudinal analysis of lymphocyte ratios and HIV-1 intracellular DNA levels in children, Cancer Research J Infect Dis, vol.61, issue.189, pp.5028-5037, 2001.

D. Scott-algara, C. Rouzioux, and S. Blanche, In Untreated HIV-1-Infected Children, PBMC-Associated HIV DNA Levels and Cell-Free HIV RNA Levels Are Correlated to Distinct T-lymphocyte Populations Regulatory T cells and chronic immune activation in human immunodeficiency virus 1 (HIV-1)-infected children, JAIDS Clin Exp Immunol, vol.53, issue.164, pp.553-563, 2010.

A. Saitoh, K. K. Singh, and S. Sandall, Association of CD4+ T-lymphocyte counts and new thymic emigrants in HIV-infected children during successful highly active antiretroviral therapy, Journal of Allergy and Clinical Immunology, vol.117, issue.4, pp.909-915, 2006.
DOI : 10.1016/j.jaci.2006.01.013

D. Rossi, A. , A. S. Walker, D. De-forni, and D. M. Gibb, Biphasic decay of cell-associated HIV-1 DNA in HIV-1-infected children on antiretroviral therapy, AIDS, vol.16, issue.14, pp.1961-1963, 2002.
DOI : 10.1097/00002030-200209270-00015

D. Rossi, A. , A. S. Walker, D. De-forni, N. Klein et al., Relationship between changes in thymic emigrants and cell-associated HIV-1 DNA in HIV-1-infected children initiating antiretroviral therapy, Antiv Ther, vol.10, pp.63-71, 2005.

A. Zoufaly, H. J. Stellbrink, and M. Der-heiden, Cumulative HIV Viremia during Highly Active Antiretroviral Therapy Is a Strong Predictorof AIDS???Related Lymphoma, The Journal of Infectious Diseases, vol.200, issue.1, pp.79-87, 2009.
DOI : 10.1086/599313

URL : http://edoc.rki.de/oa/articles/reptYWi13tDKk/PDF/223SAOkwBZS2k.pdf

J. P. Viard, M. Burgard, and J. B. Hubert, Impact of 5 years of maximally successful highly active antiretroviral therapy on CD4 cell count and HIV-1 DNA level, AIDS, vol.18, issue.1, pp.45-49, 2004.
DOI : 10.1097/00002030-200401020-00005

M. Burgard, F. Boufassa, and J. P. Viard, Factors influencing peripheral blood mononuclear cell-associated HIV-1 DNA level after long-term suppressive antiretroviral therapy in 236 patients, AIDS, vol.23, issue.16, pp.2165-2171, 2009.
DOI : 10.1097/QAD.0b013e32833032d4

V. Avettand-fenoel, P. Flandre, and M. L. Chaix, Impact of 48 week lopinavir/ritonavir monotherapy on blood cell-associated HIV-1-DNA in the MONARK trial, Journal of Antimicrobial Chemotherapy, vol.65, issue.5
DOI : 10.1093/jac/dkq084

J. Antimic-chem, C. , L. Weiss, and L. Assoumou, A high HIV DNA level in PBMCs at antiretroviral treatment interruption predicts a shorter time to treatment resumption, independently of the CD4 nadir, J Med Virol, vol.65, issue.82, pp.1005-1007, 2010.

A. Guihot, R. Tubiana, and G. Breton, Immune and virological benefits of 10 years of permanent viral control with antiretroviral therapy Persistence of human immunodeficiency virus (HIV) type 1 DNA in peripheral blood despite prolonged suppression of plasma HIV-1 RNA in children Long-term decay of the HIV-1 reservoir in HIV-1-infected children treated with highly active antiretroviral therapy, AIDS J Infect Dis J Infect Dis, vol.24, issue.193, pp.614-619, 2002.

S. R. Cole, S. Napravnik, and M. J. Mugavero, Copy-Years Viremia as a Measure of Cumulative Human Immunodeficiency Virus Viral Burden, American Journal of Epidemiology, vol.171, issue.2, pp.198-205, 2010.
DOI : 10.1093/aje/kwp347

T. W. Chun, J. S. Justement, and P. Pandya, T Cell Ratios in Aviremic HIV???1???Infected Individuals Receiving Long???Term Highly Active Antiretroviral Therapy, The Journal of Infectious Diseases, vol.185, issue.11, pp.1672-1676, 2002.
DOI : 10.1086/340521

N. Chomont, M. El-far, and P. Ancuta, HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation, Nature Medicine, vol.45, issue.8, pp.893-92, 2009.
DOI : 10.1038/nm.1972

M. Hainaut, M. Ducarme, and L. Schandene, Age-related immune reconstitution during highly active antiretroviral therapy in human immunodeficiency virus type 1-infected children, The Pediatric Infectious Disease Journal, vol.22, issue.1, pp.62-69, 2003.
DOI : 10.1097/00006454-200301000-00016

A. Anselmi, D. Vendrame, and O. Rampon, Immune reconstitution in human immunodeficiency virus type 1-infected children with different virological responses to anti-retroviral therapy, Clinical & Experimental Immunology, vol.192, issue.3, pp.442-450, 2007.
DOI : 10.1111/j.1365-2249.2007.03526.x

A. Weinberg, R. Dickover, and P. Britto, Continuous improvement in the immune system of HIV-infected children on prolonged antiretroviral therapy, AIDS, vol.22, issue.17, pp.2267-2277, 2008.
DOI : 10.1097/QAD.0b013e3283189bb3

C. F. Kelley, C. M. Kitchen, and P. W. Hunt, Cell Count Restoration in HIV???Infected Patients Receiving Long???Term Antiretroviral Treatment, Clinical Infectious Diseases, vol.48, issue.6, pp.787-794, 2009.
DOI : 10.1086/597093

J. J. Lok, R. J. Bosch, and C. A. Benson, Long-term increase in CD4+ T-cell counts during combination antiretroviral therapy for HIV-1 infection, AIDS, vol.24, issue.12, pp.1867-1876, 2010.
DOI : 10.1097/QAD.0b013e32833adbcf

C. A. Available-at-sabin, C. J. Smith, and A. D. Monforte, sante-jeunesse-sports.gouv.fr/dossiers/sante/sida 41 Response to combination antiretroviral therapy: variation by age -The Collaboration of Observational HIV Epidemiological Research Europe (COHERE) study group, AIDS, vol.22, pp.1463-1473, 2008.

H. Rna, H. Lifetime-zenith, and . Rna, Cumulative duration of HIV RNA < 500 copies/ml a , median [IQR] Duration of last period of HIV RNA < 500 copies/ml a , median