N. Tobin and G. Aldrovandi, Immunology of pediatric HIV infection, Immunological Reviews, vol.51, issue.Suppl, pp.143-69, 2013.
DOI : 10.1097/QAI.0b013e31819df249

C. Shiu, C. Cunningham, and T. Greenough, Identification of Ongoing Human Immunodeficiency Virus Type 1 (HIV-1) Replication in Residual Viremia during Recombinant HIV-1 Poxvirus Immunizations in Patients with Clinically Undetectable Viral Loads on Durable Suppressive Highly Active Antiretroviral Therapy, Journal of Virology, vol.83, issue.19, pp.9731-9773, 2009.
DOI : 10.1128/JVI.00570-09

D. King and E. Larsson-sciard, Clonal evolution of CD8+ T-cell expansions in HIV-infected patients on long-term HAART, Clinical and Experimental Immunology, vol.184, issue.2, pp.280-286, 2001.
DOI : 10.1084/jem.184.5.1815

L. Shan, K. Deng, and N. Shroff, Stimulation of HIV-1-Specific Cytolytic T Lymphocytes Facilitates Elimination of Latent Viral Reservoir after Virus Reactivation, Immunity, vol.36, issue.3, pp.491-501, 2012.
DOI : 10.1016/j.immuni.2012.01.014

S. Deeks, B. Autran, and B. Berkhout, Towards an HIV cure: a global scientific strategy, Nature Reviews Immunology, vol.2, issue.8, pp.607-621, 2012.
DOI : 10.1126/scitranslmed.3000931
URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3595991/pdf

V. Avettand-fenoel, S. Blanche, L. Chenadec, and J. , Relationships Between HIV Disease History and Blood HIV-1 DNA Load in Perinatally Infected Adolescents and Young Adults: The ANRS-EP38-IMMIP Study, The Journal of Infectious Diseases, vol.205, issue.10, pp.1520-1528, 2012.
DOI : 10.1093/infdis/jis233
URL : https://hal.archives-ouvertes.fr/pasteur-01418092

S. Blanche, D. Scott-algara, L. Chenadec, and J. , Naive T Lymphocytes and Recent Thymic Emigrants Are Associated With HIV-1 Disease History in French Adolescents and Young Adults Infected in the Perinatal Period: The ANRS-EP38-IMMIP Study, Clinical Infectious Diseases, vol.58, issue.4, pp.573-87, 2014.
DOI : 10.1093/cid/cit729
URL : https://hal.archives-ouvertes.fr/pasteur-01418085

L. Chenadec, J. Scott-algara, D. Blanche, and S. , Gag-Specific CD4 and CD8 T-Cell Proliferation in Adolescents and Young Adults with Perinatally Acquired HIV-1 Infection Is Associated with Ethnicity ??? The ANRS-EP38-IMMIP Study, PLOS ONE, vol.23, issue.12, p.144706, 2015.
DOI : 10.1371/journal.pone.0144706.t004
URL : https://hal.archives-ouvertes.fr/pasteur-01416577

S. Josefowicz, L. Lu, and A. Rudensky, Regulatory T Cells: Mechanisms of Differentiation and Function, Annual Review of Immunology, vol.30, issue.1, pp.531-64, 2012.
DOI : 10.1146/annurev.immunol.25.022106.141623

D. Scott-algara, J. Warszawski, L. Chenadec, and J. , Gag-Specific CD4 T Cell Proliferation, Plasmacytoid Dendritic Cells, and Ethnicity in Perinatally HIV-1-Infected Youths: The ANRS-EP38-IMMIP Study, AIDS Research and Human Retroviruses, vol.33, issue.1, 2016.
DOI : 10.1089/aid.2016.0177

S. Hamilton and S. Jameson, CD8 T cell quiescence revisited, Trends in Immunology, vol.33, issue.5, pp.224-254, 2012.
DOI : 10.1016/j.it.2012.01.007
URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3348359/pdf

M. Chevalier and L. Weiss, The split personality of regulatory T cells in HIV infection, Blood, vol.121, issue.1, pp.29-37, 2013.
DOI : 10.1182/blood-2012-07-409755

M. Travis and D. Sheppard, TGF-?? Activation and Function in Immunity, Annual Review of Immunology, vol.32, issue.1, pp.51-82, 2014.
DOI : 10.1146/annurev-immunol-032713-120257
URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010192/pdf

C. Ma and N. Zhang, Transforming growth factor-?? signaling is constantly shaping memory T-cell population, Proceedings of the National Academy of Sciences, vol.15, issue.4, pp.11013-11020, 2015.
DOI : 10.1073/pnas.1010201107
URL : http://www.pnas.org/content/112/35/11013.full.pdf

C. Filippi, A. Juedes, and J. Oldham, Transforming Growth Factor-?? Suppresses the Activation of CD8+ T-Cells When Naive but Promotes Their Survival and Function Once Antigen Experienced: A Two-Faced Impact on Autoimmunity, Diabetes, vol.57, issue.10, pp.2684-92, 2008.
DOI : 10.2337/db08-0609

S. Schwartzkopff, S. Woyciechowski, and U. Aichele, T cells, European Journal of Immunology, vol.59, issue.8, pp.2212-2219, 2015.
DOI : 10.1002/hep.26731

M. Moreno-fernandez, P. Presicce, and C. Chougnet, Homeostasis and Function of Regulatory T Cells in HIV/SIV Infection, Journal of Virology, vol.86, issue.19, pp.10262-10271, 2012.
DOI : 10.1128/JVI.00993-12

A. Kinter, M. Hennessey, and A. Bell, HIV-specific T Cell Immune Responses In Vitro and Are Associated with Favorable Clinical Markers of Disease Status, The Journal of Experimental Medicine, vol.38, issue.3, pp.331-374, 2004.
DOI : 10.1016/S0006-291X(02)02460-9

L. Weiss, V. Donkova-petrini, and L. Caccavelli, Human immunodeficiency virus-driven expansion of CD4+CD25+ regulatory T cells, which suppress HIV-specific CD4 T-cell responses in HIV-infected patients, Blood, vol.104, issue.10, pp.3249-56, 2004.
DOI : 10.1182/blood-2004-01-0365

Y. He, J. Li, and Y. Zheng, A Randomized Case???Control Study of Dynamic Changes in Peripheral Blood Th17/Treg Cell Balance and Interleukin-17 Levels in Highly Active Antiretroviral-Treated HIV Type 1/AIDS Patients, AIDS Research and Human Retroviruses, vol.28, issue.4, pp.339-384, 2012.
DOI : 10.1089/aid.2011.0140

M. Jenabian, M. Patel, and I. Kema, Distinct Tryptophan Catabolism and Th17/Treg Balance in HIV Progressors and Elite Controllers, PLoS ONE, vol.201, issue.10, p.78146, 2013.
DOI : 10.1371/journal.pone.0078146.s002
URL : https://doi.org/10.1371/journal.pone.0078146

K. Allers, A. Puyskens, and H. Epple, The effect of timing of antiretroviral therapy on CD4+ T-cell reconstitution in the intestine of HIV-infected patients, Mucosal Immunology, vol.9, issue.1, pp.265-74, 2016.
DOI : 10.1182/blood-2010-09-309591

J. Falivene, Y. Ghiglione, and N. Laufer, Th17 and Th17/Treg ratio at early HIV infection associate with protective HIV-specific CD8+ T-cell responses and disease progression, Scientific Reports, vol.301, issue.1, p.11511, 2015.
DOI : 10.1016/j.jim.2005.03.015
URL : http://www.nature.com/articles/srep11511.pdf

M. Macal, S. Sankaran, and T. Chun, Effective CD4+ T-cell restoration in gut-associated lymphoid tissue of HIV-infected patients is associated with enhanced Th17 cells and polyfunctional HIV-specific T-cell responses, Mucosal Immunology, vol.175, issue.6, pp.475-88, 2008.
DOI : 10.4049/jimmunol.175.8.5532

D. Hartigan-o-'connor, K. Abel, and K. Van-rompay, SIV replication in the infected rhesus macaque is limited by the size of the preexisting TH17 cell compartment, Sci Transl Med, vol.4, pp.136-69, 2012.

C. Baker, L. Swainson, and D. Lin, Exposure to SIV in utero results in reduced viral loads and altered responsiveness to postnatal challenge, Science Translational Medicine, vol.67, issue.300, pp.300-125, 2015.
DOI : 10.1038/nature12519

F. Legrand, D. Nixon, and C. Loo, Strong HIV-1-Specific T Cell Responses in HIV-1-Exposed Uninfected Infants and Neonates Revealed after Regulatory T Cell Removal, PLoS ONE, vol.112, issue.1, p.102, 2006.
DOI : 10.1371/journal.pone.0000102.t003
URL : https://doi.org/10.1371/journal.pone.0000102

D. Hartigan-o-'connor, K. Abel, and J. Mccune, T cells by infant but not adult macaque regulatory T cells: implications for SIV disease progression, The Journal of Experimental Medicine, vol.7, issue.2, pp.2679-92, 2007.
DOI : 10.1097/00002030-199801000-00001

X. Wang, H. Xu, and C. Shen, Profound loss of intestinal Tregs in acutely SIV-infected neonatal macaques, Journal of Leukocyte Biology, vol.97, issue.2, pp.391-400, 2015.
DOI : 10.1189/jlb.4A0514-266RR

R. Freguja, K. Gianesin, and I. Mosconi, Regulatory T cells and chronic immune activation in human immunodeficiency virus 1 (HIV-1)-infected children, Clinical & Experimental Immunology, vol.25, issue.3, pp.373-80, 2011.
DOI : 10.1089/aid.2008.0140
URL : http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2249.2011.04383.x/pdf

R. Argüello, J. Balbaryski, and G. Barboni, Altered frequency and phenotype of CD4+ forkhead box protein 3+ T cells and its association with autoantibody production in human immunodeficiency virus-infected paediatric patients, Clinical & Experimental Immunology, vol.65, issue.2, pp.224-257, 2012.
DOI : 10.1046/j.1365-3083.2000.00820.x

L. Ndhlovu, J. Chapman, and A. Jha, Suppression of HIV-1 plasma viral load below detection preserves IL-17 producing T cells in HIV-1 infection, AIDS, vol.22, issue.8, pp.990-992, 2008.
DOI : 10.1097/QAD.0b013e3282ff884e

D. Favre, J. Mold, and P. Hunt, Tryptophan catabolism by indoleamine 2,3-diox- ygenase 1 alters the balance of TH17 to regulatory T cells in HIV disease, Sci Transl Med, vol.2, pp.32-36, 2010.

M. Chevalier, G. Petitjean, and C. Dunyach-rémy, The Th17/Treg Ratio, IL-1RA and sCD14 Levels in Primary HIV Infection Predict the T-cell Activation Set Point in the Absence of Systemic Microbial Translocation, PLoS Pathogens, vol.42, issue.1, p.1003453, 2013.
DOI : 10.1371/journal.ppat.1003453.s003

H. Kared, J. Lelièvre, and V. Donkova-petrini, HIV-specific regulatory T cells are associated with higher CD4 cell counts in primary infection, AIDS, vol.22, issue.18, pp.2451-60, 2008.
DOI : 10.1097/QAD.0b013e328319edc0
URL : https://hal.archives-ouvertes.fr/inserm-00350026

F. Simonetta, C. Lecuroux, and I. Girault, Early and Long-Lasting Alteration of Effector CD45RA???Foxp3high Regulatory T-Cell Homeostasis During HIV Infection, The Journal of Infectious Diseases, vol.205, issue.10, pp.1510-1519, 2012.
DOI : 10.1093/infdis/jis235
URL : https://hal.archives-ouvertes.fr/inserm-00865957

C. Kornfeld, M. Ploquin, and I. Pandrea, Antiinflammatory profiles during primary SIV infection in African green monkeys are associated with protection against AIDS, Journal of Clinical Investigation, vol.115, issue.4, pp.1082-91, 2005.
DOI : 10.1172/JCI23006
URL : http://www.jci.org/articles/view/23006C1/files/pdf

. Gynécologie-obstétrique, Groupe Hospitalier Cochin Tarnier-Port-Royal, Paris (Ghislaine Firtion

I. Pédiatrique, Groupe Hospitalier Necker-Enfants Malades