A. Bharti, J. Nally, J. Ricaldi, M. Matthias, and M. Diaz, Leptospirosis: a zoonotic disease of global importance, The Lancet Infectious Diseases, vol.3, issue.12, pp.757-771, 2003.
DOI : 10.1016/S1473-3099(03)00830-2

I. Mc and G. Montgomery, Renal lesions in Leptospira canicola infection in dogs, J Pathol Bacteriol, vol.64, pp.145-160, 1952.

E. Atasoyu, V. Turhan, S. Unver, T. Evrenkaya, and S. Yildirim, A case of leptospirosis presenting with end-stage renal failure, Nephrology Dialysis Transplantation, vol.20, issue.10, pp.2290-2292, 2005.
DOI : 10.1093/ndt/gfi014

C. Yang, Leptospirosis in Taiwan?an underestimated infectious disease, Chang Gung Med J, vol.30, pp.109-115, 2007.

M. Bandeira, C. Santos, E. De-azevedo, L. Soares, and J. Macedo, Attenuated Nephritis in Inducible Nitric Oxide Synthase Knockout C57BL/6 Mice and Pulmonary Hemorrhage in CB17 SCID and Recombination Activating Gene 1 Knockout C57BL/6 Mice Infected with Leptospira interrogans, Infection and Immunity, vol.79, issue.7, pp.2936-2940, 2011.
DOI : 10.1128/IAI.05099-11

C. Werts, R. Tapping, J. Mathison, T. Chuang, and V. Kravchenko, Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanism, Nature Immunology, vol.5, issue.4, pp.346-352, 2001.
DOI : 10.1038/86354

C. Yang and M. Wu, Leptospirosis renal disease, Nephrology Dialysis Transplantation, vol.16, issue.suppl 5, pp.73-77, 2001.
DOI : 10.1093/ndt/16.suppl_5.73
URL : http://ndt.oxfordjournals.org/cgi/content/short/16/suppl_5/73

Y. Tian, Y. Chen, C. Hung, C. Chang, and M. Wu, Leptospiral Outer Membrane Protein Induces Extracellular Matrix Accumulation through a TGF-beta1/Smad-Dependent Pathway, Journal of the American Society of Nephrology, vol.17, issue.10, pp.2792-2798, 2006.
DOI : 10.1681/ASN.2006020159

Y. Tian, C. Hung, Y. Li, Y. Chen, and M. Chang, Leptospira santorosai Serovar Shermani Detergent Extract Induces an Increase in Fibronectin Production through a Toll-Like Receptor 2-Mediated Pathway, Infection and Immunity, vol.79, issue.3, pp.1134-1142, 2011.
DOI : 10.1128/IAI.01287-09

C. Chassin, M. Picardeau, J. Goujon, P. Bourhy, and N. Quellard, TLR4- and TLR2-Mediated B Cell Responses Control the Clearance of the Bacterial Pathogen, Leptospira interrogans, The Journal of Immunology, vol.183, issue.4, pp.2669-2677, 2009.
DOI : 10.4049/jimmunol.0900506

S. Lacroix-lamande, M. Andon, E. Michel, G. Ratet, and D. Philpott, Downregulation of the Na/K-ATPase Pump by Leptospiral Glycolipoprotein Activates the NLRP3 Inflammasome, The Journal of Immunology, vol.188, issue.6, pp.2805-2814, 2012.
DOI : 10.4049/jimmunol.1101987

P. Gasse, N. Riteau, S. Charron, S. Girre, and L. Fick, Uric Acid Is a Danger Signal Activating NALP3 Inflammasome in Lung Injury Inflammation and Fibrosis, American Journal of Respiratory and Critical Care Medicine, vol.179, issue.10, pp.903-913, 2009.
DOI : 10.1164/rccm.200808-1274OC
URL : https://hal.archives-ouvertes.fr/hal-00404885

T. Aoyama, Y. Paik, and E. Seki, Toll-Like Receptor Signaling and Liver Fibrosis, Gastroenterology Research and Practice, vol.17, issue.5, 2010.
DOI : 10.1038/nature08780
URL : http://doi.org/10.1155/2010/192543

M. Campbell, K. Hile, H. Zhang, H. Asanuma, and B. Vanderbrink, Toll-Like Receptor 4: A Novel Signaling Pathway During Renal Fibrogenesis, Journal of Surgical Research, vol.168, issue.1, pp.61-69, 2011.
DOI : 10.1016/j.jss.2009.09.053
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2888706

L. Liu, P. Kou, Q. Zeng, G. Pei, and Y. Li, CD4+ T Lymphocytes, Especially Th2 Cells, Contribute to the Progress of Renal Fibrosis, American Journal of Nephrology, vol.36, issue.4, pp.386-396, 2012.
DOI : 10.1159/000343283

B. Conway and J. Hughes, Cellular orchestrators of renal fibrosis, QJM, vol.105, issue.7, pp.611-615, 2012.
DOI : 10.1093/qjmed/hcr235

N. Que-gewirth, A. Ribeiro, S. Kalb, R. Cotter, and D. Bulach, A Methylated Phosphate Group and Four Amide-linked Acyl Chains in Leptospira interrogans Lipid A: THE MEMBRANE ANCHOR OF AN UNUSUAL LIPOPOLYSACCHARIDE THAT ACTIVATES TLR2, Journal of Biological Chemistry, vol.279, issue.24, pp.25420-25429, 2004.
DOI : 10.1074/jbc.M400598200

J. Goujon, A. Vandewalle, H. Baumert, M. Carretier, and T. Hauet, Influence of cold-storage conditions on renal function of autotransplanted large pig kidneys, Kidney International, vol.58, issue.2, pp.838-850, 2000.
DOI : 10.1046/j.1523-1755.2000.00233.x

Y. Tsubata, F. Akiyama, T. Oya, J. Ajiro, and T. Saeki, IgG4-related Chronic Tubulointerstitial Nephritis without Autoimmune Pancreatitis and the Time Course of Renal Function, Internal Medicine, vol.49, issue.15, pp.1593-1598, 2010.
DOI : 10.2169/internalmedicine.49.3787

S. Cheng, A. Pollock, R. Mahimkar, J. Olson, and D. Lovett, Matrix metalloproteinase 2 and basement membrane integrity: a unifying mechanism for progressive renal injury, The FASEB Journal, vol.20, issue.11, pp.1898-1900, 2006.
DOI : 10.1096/fj.06-5898fje

M. Tucunduva-de-faria, D. Athanazio, G. Ramos, E. Silva, E. Reis et al., Morphological Alterations in the Kidney of Rats with Natural and Experimental Leptospira Infection, Journal of Comparative Pathology, vol.137, issue.4, pp.231-238, 2007.
DOI : 10.1016/j.jcpa.2007.08.001

D. Athanazio, E. Silva, C. Santos, G. Rocha, and M. Vannier-santos, Rattus norvegicus as a model for persistent renal colonization by pathogenic Leptospira interrogans, Acta Tropica, vol.105, issue.2, pp.176-180, 2008.
DOI : 10.1016/j.actatropica.2007.10.012

A. Monahan, J. Callanan, and J. Nally, Review Paper: Host-Pathogen Interactions in the Kidney during Chronic Leptospirosis, Veterinary Pathology, vol.48, issue.5, pp.792-799, 2009.
DOI : 10.1016/S0002-9440(10)63198-7

M. Pereira, J. Andrade, R. Marchevsky, R. Santos, and R. , Morphological characterization of lung and kidney lesions inC3H/HeJ mice infected with Leptospira interrogans serovar icterohaemorrhagiae: Defect of CD4+ and CD8+ T-cells are prognosticators of the disease progression, Experimental and Toxicologic Pathology, vol.50, issue.3, pp.191-198, 1998.
DOI : 10.1016/S0940-2993(98)80083-3

A. Farris and R. Colvin, Renal interstitial fibrosis, Current Opinion in Nephrology and Hypertension, vol.21, issue.3, pp.289-300, 2012.
DOI : 10.1097/MNH.0b013e3283521cfa

S. Huen, G. Moeckel, and L. Cantley, Macrophage-specific deletion of transforming growth factor-??1 does not prevent renal fibrosis after severe ischemia-reperfusion or obstructive injury, AJP: Renal Physiology, vol.305, issue.4, pp.477-84, 2013.
DOI : 10.1152/ajprenal.00624.2012

M. Pereira, D. Silva, J. Pinto, M. , D. Silva et al., Experimental leptospirosis in marmoset monkeys (Callithrix jacchus): a new model for studies of severe pulmonary leptospirosis, Am J Trop Med Hyg, vol.72, pp.13-20, 2005.

J. Silva, M. Dalston, J. Carvalho, S. Setubal, and J. Oliveira, Clinicopathological and immunohistochemical featuresof the severe pulmonary form of leptospirosis, Revista da Sociedade Brasileira de Medicina Tropical, vol.35, issue.4, pp.395-399, 2002.
DOI : 10.1590/S0037-86822002000400017

C. Hung, C. Chang, K. Chen, Y. Tian, and M. Wu, Upregulation of chemokine CXCL1/KC by leptospiral membrane lipoprotein preparation in renal tubule epithelial cells, Kidney International, vol.69, issue.10, pp.1814-1822, 2006.
DOI : 10.1038/sj.ki.5000362

C. Hung, C. Chang, Y. Tian, M. Wu, and C. Yu, Leptospiral membrane proteins stimulate pro-inflammatory chemokines secretion by renal tubule epithelial cells through toll-like receptor 2 and p38 mitogen activated protein kinase, Nephrology Dialysis Transplantation, vol.21, issue.4, pp.898-910, 2006.
DOI : 10.1093/ndt/gfi316
URL : http://ndt.oxfordjournals.org/cgi/content/short/21/4/898

C. Yang, C. Hung, M. Wu, Y. Tian, and C. Chang, Toll-like receptor 2 mediates early inflammation by leptospiral outer membrane proteins in proximal tubule cells, Kidney International, vol.69, issue.5, pp.815-822, 2006.
DOI : 10.1038/sj.ki.5000119

M. Nahori, E. Fournie-amazouz, N. Que-gewirth, V. Balloy, and M. Chignard, Differential TLR Recognition of Leptospiral Lipid A and Lipopolysaccharide in Murine and Human Cells, The Journal of Immunology, vol.175, issue.9, pp.6022-6031, 2005.
DOI : 10.4049/jimmunol.175.9.6022

T. Saeki, S. Nishi, N. Imai, T. Ito, and H. Yamazaki, Clinicopathological characteristics of patients with IgG4-related tubulointerstitial nephritis, Kidney International, vol.78, issue.10, pp.1016-1023, 2010.
DOI : 10.1038/ki.2010.271

G. Goncalves, A. Castoldi, T. Braga, and N. Camara, New Roles for Innate Immune Response in Acute and Chronic Kidney Injuries, Scandinavian Journal of Immunology, vol.139, issue.2, pp.428-435, 2011.
DOI : 10.1111/j.1365-3083.2011.02523.x

T. Braga, M. Correa-costa, Y. Guise, A. Castoldi, and C. De-oliveira, MyD88 signaling pathway is involved in renal fibrosis by favoring a TH2 immune response and activating alternative M2 macrophages, Mol Med, vol.18, pp.1231-1239, 2012.

V. Skuginna, M. Lech, R. Allam, M. Ryu, and S. Clauss, Toll-Like Receptor Signaling and SIGIRR in Renal Fibrosis upon Unilateral Ureteral Obstruction, PLoS ONE, vol.8, issue.4, p.19204, 2011.
DOI : 10.1371/journal.pone.0019204.t001

L. Bourhis and C. Werts, Role of Nods in bacterial infection, Microbes and Infection, vol.9, issue.5, pp.629-636, 2007.
DOI : 10.1016/j.micinf.2007.01.014

L. Slamti, M. De-pedro, E. Guichet, and M. Picardeau, Deciphering Morphological Determinants of the Helix-Shaped Leptospira, Journal of Bacteriology, vol.193, issue.22, pp.6266-6275, 2011.
DOI : 10.1128/JB.05695-11

J. Liu, D. Kennedy, Y. Yan, and J. Shapiro, Reactive Oxygen Species Modulation of Na/K-ATPase Regulates Fibrosis and Renal Proximal Tubular Sodium Handling, International Journal of Nephrology, vol.145, issue.5, p.381320, 2012.
DOI : 10.1046/j.0001-6772.2003.01203.x

S. Heemskerk, P. Pickkers, M. Bouw, A. Draisma, and J. Van-der-hoeven, Upregulation of Renal Inducible Nitric Oxide Synthase during Human Endotoxemia and Sepsis Is Associated with Proximal Tubule Injury, Clinical Journal of the American Society of Nephrology, vol.1, issue.4, pp.853-862, 2006.
DOI : 10.2215/CJN.00490206

E. Chow, J. Deville, J. Nally, M. Lovett, and K. Nielsen-saines, Prolonged leptospira urinary shedding in a 10-year-old girl. Case Rep Pediatr, p.169013, 2012.

C. Ganoza, M. Matthias, M. Saito, M. Cespedes, and E. Gotuzzo, Asymptomatic Renal Colonization of Humans in the Peruvian Amazon by Leptospira, PLoS Neglected Tropical Diseases, vol.171, issue.2, p.612, 2010.
DOI : 10.1371/journal.pntd.0000612.s003