A. Saez-cirion and G. Pancino, HIV controllers: a genetically determined or inducible phenotype?, Immunological Reviews, vol.473, issue.1, pp.281-294, 2013.
DOI : 10.1111/imr.12076

URL : https://hal.archives-ouvertes.fr/pasteur-01420535

M. Betts, M. Nason, S. West, D. Rosa, S. Migueles et al., HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells, Blood, vol.107, issue.12, pp.4781-4789, 2006.
DOI : 10.1182/blood-2005-12-4818

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1895811

S. Migueles, A. Laborico, W. Shupert, M. Sabbaghian, R. Rabin et al., HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressors, Nature Immunology, vol.3, issue.11, pp.1061-1068, 2002.
DOI : 10.1038/ni845

A. Saez-cirion, C. Lacabaratz, O. Lambotte, P. Versmisse, A. Urrutia et al., HIV controllers exhibit potent CD8 T cell capacity to suppress HIV infection ex vivo and peculiar cytotoxic T lymphocyte activation phenotype, Proceedings of the National Academy of Sciences, vol.104, issue.16, pp.6776-6781, 2007.
DOI : 10.1073/pnas.0611244104

URL : https://hal.archives-ouvertes.fr/pasteur-00142658

P. Flores-villanueva, E. Yunis, J. Delgado, E. Vittinghoff, S. Buchbinder et al., Control of HIV-1 viremia and protection from AIDS are associated with HLA-Bw4 homozygosity, Proceedings of the National Academy of Sciences, vol.98, issue.9, pp.5140-5145, 2001.
DOI : 10.1073/pnas.071548198

S. Migueles, M. Sabbaghian, W. Shupert, M. Bettinotti, F. Marincola et al., HLA B*5701 is highly associated with restriction of virus replication in a subgroup of HIV, 2000.

F. Pereyra, X. Jia, P. Mclaren, A. Telenti, P. De-bakker et al., The major genetic determinants of HIV-1 control affect HLA class I peptide presentation, Science, vol.330, pp.1551-1557, 2010.

C. Lecuroux, A. Saez-cirion, I. Girault, P. Versmisse, F. Boufassa et al., Both HLA-B*57 and Plasma HIV RNA Levels Contribute to the HIV-Specific CD8+ T Cell Response in HIV Controllers, Journal of Virology, vol.88, issue.1, pp.176-18702098, 2014.
DOI : 10.1128/JVI.02098-13

URL : https://hal.archives-ouvertes.fr/pasteur-01420526

A. Saez-cirion, M. Sinet, S. Shin, A. Urrutia, P. Versmisse et al., Heterogeneity in HIV Suppression by CD8 T Cells from HIV Controllers: Association with Gag-Specific CD8 T Cell Responses, The Journal of Immunology, vol.182, issue.12, pp.7828-7837, 2009.
DOI : 10.4049/jimmunol.0803928

T. Bruel, C. Hamimi, N. Dereuddre-bosquet, A. Cosma, S. Shin et al., ABSTRACT, Journal of Virology, vol.89, issue.7, pp.3542-355603723, 2015.
DOI : 10.1128/JVI.03723-14

M. Addo, R. Draenert, A. Rathod, C. Verrill, B. Davis et al., Fully Differentiated HIV-1 Specific CD8+ T Effector Cells Are More Frequently Detectable in Controlled than in Progressive HIV-1 Infection, PLoS ONE, vol.77, issue.3, p.321, 2007.
DOI : 10.1371/journal.pone.0000321.t001

Z. Ndhlovu, J. Proudfoot, K. Cesa, D. Alvino, A. Mcmullen et al., Elite Controllers with Low to Absent Effector CD8+ T Cell Responses Maintain Highly Functional, Broadly Directed Central Memory Responses, Journal of Virology, vol.86, issue.12, pp.6959-696900531, 2012.
DOI : 10.1128/JVI.00531-12

J. Blankson, J. Bailey, S. Thayil, H. Yang, K. Lassen et al., Isolation and characterization of replication-competent human immunodeficiency virus type 1, 2007.

A. Lamine, A. Caumont-sarcos, M. Chaix, A. Saez-cirion, C. Rouzioux et al., Replication-competent HIV strains infect HIV controllers despite undetectable viremia (ANRS EP36 study), AIDS, vol.21, issue.8, pp.1043-1045, 2007.
DOI : 10.1097/QAD.0b013e3280d5a7ac

URL : https://hal.archives-ouvertes.fr/hal-00166186

T. Miura, M. Brockman, C. Brumme, Z. Brumme, J. Carlson et al., Genetic Characterization of Human Immunodeficiency Virus Type 1 in Elite Controllers: Lack of Gross Genetic Defects or Common Amino Acid Changes, Journal of Virology, vol.82, issue.17, pp.8422-843000535, 2008.
DOI : 10.1128/JVI.00535-08

S. Lewin and C. Rouzioux, HIV cure and eradication: how will we get from the laboratory to effective clinical trials?, AIDS, vol.25, issue.7, pp.885-897, 2011.
DOI : 10.1097/QAD.0b013e3283467041

A. Saez-cirion, C. Hamimi, A. Bergamaschi, A. David, P. Versmisse et al., Restriction of HIV-1 replication in macrophages and CD4+ T cells from HIV controllers, Blood, vol.118, issue.4, pp.955-964, 2011.
DOI : 10.1182/blood-2010-12-327106

URL : https://hal.archives-ouvertes.fr/pasteur-01420583

A. Hill, D. Rosenbloom, F. Fu, M. Nowak, and R. Siliciano, Predicting the outcomes of treatment to eradicate the latent reservoir for HIV-1, Proceedings of the National Academy of Sciences, vol.111, issue.37, pp.13475-13480, 2014.
DOI : 10.1073/pnas.1406663111

L. Assoumou, L. Weiss, C. Piketty, M. Burgard, A. Melard et al., A low HIV-DNA level in peripheral blood mononuclear cells at antiretroviral treatment interruption predicts a higher probability of maintaining viral control, AIDS, vol.29, issue.15, pp.2003-2007
DOI : 10.1097/QAD.0000000000000734

C. Goujard, I. Girault, C. Rouzioux, C. Lecuroux, C. Deveau et al., HIV-1 control after transient antiretroviral treatment initiated in primary infection: role of patient characteristics and effect of therapy, Antiviral Therapy, vol.17, issue.6, pp.1001-1009, 2012.
DOI : 10.3851/IMP2273

L. Hocqueloux, T. Prazuck, V. Avettand-fenoel, A. Lafeuillade, B. Cardon et al., Long-term immunovirologic control following antiretroviral therapy interruption in patients treated at the time of primary HIV-1 infection, AIDS, vol.24, issue.10, pp.1598-1601, 2010.
DOI : 10.1097/QAD.0b013e32833b61ba

S. Yerly, H. Gunthard, C. Fagard, B. Joos, T. Perneger et al., Proviral HIV-DNA predicts viral rebound and viral setpoint after structured treatment interruptions, AIDS, vol.18, issue.14, pp.1951-1953, 2004.
DOI : 10.1097/00002030-200409240-00011

T. Henrich, E. Hanhauser, F. Marty, M. Sirignano, S. Keating et al., Antiretroviral-Free HIV-1 Remission and Viral Rebound After Allogeneic Stem Cell Transplantation, Annals of Internal Medicine, vol.161, issue.5, pp.319-327, 2014.
DOI : 10.7326/M14-1027

S. Reuse, M. Calao, K. Kabeya, A. Guiguen, J. Gatot et al., Synergistic Activation of HIV-1 Expression by Deacetylase Inhibitors and Prostratin: Implications for Treatment of Latent Infection, PLoS ONE, vol.4, issue.6, p.6093, 2009.
DOI : 10.1371/journal.pone.0006093.s008

URL : https://hal.archives-ouvertes.fr/hal-00464770

F. Rouet, M. Chaix, E. Nerrienet, N. Ngo-giang-huong, J. Plantier et al., Impact of HIV-1 Genetic Diversity on Plasma HIV-1 RNA Quantification, JAIDS Journal of Acquired Immune Deficiency Syndromes, vol.45, issue.4, pp.380-388, 2007.
DOI : 10.1097/QAI.0b013e3180640cf5

V. Avettand-fenoel, M. Chaix, S. Blanche, M. Burgard, C. Floch et al., LTR real-time PCR for HIV-1 DNA quantitation in blood cells for early diagnosis in infants born to seropositive mothers treated in HAART area (ANRS CO 01), J Med Virol, vol.81, pp.217-223, 2009.

V. Avettand-fenoel, T. Prazuck, L. Hocqueloux, A. Melard, C. Michau et al., HIV-DNA in rectal cells is well correlated with HIV-DNA in blood in different groups of patients, including long-term non-progressors, AIDS, vol.22, issue.14, pp.1880-1882, 2008.
DOI : 10.1097/QAD.0b013e32830fbdbc

J. Dalmau, F. Codoner, I. Erkizia, M. Pino, C. Pou et al., In???Depth Characterization of Viral Isolates from Plasma and Cells Compared with Plasma Circulating Quasispecies in Early HIV-1 Infection, PLoS ONE, vol.83, issue.2, 2012.
DOI : 10.1371/journal.pone.0032714.s001

J. Prado, A. Prendergast, C. Thobakgale, C. Molina, G. Tudor-williams et al., Replicative capacity of human HIV-1 Control and Frequency of Infected Cells, 2010.

A. Saez-cirion, S. Shin, P. Versmisse, F. Barre-sinoussi, and G. Pancino, Ex vivo T cell???based HIV suppression assay to evaluate HIV-specific CD8+ T-cell responses, Nature Protocols, vol.178, issue.6, pp.1033-1041, 2010.
DOI : 10.1038/nprot.2006.268

URL : https://hal.archives-ouvertes.fr/pasteur-01420584

Y. Ho, L. Shan, N. Hosmane, J. Wang, S. Laskey et al., Replication-Competent Noninduced Proviruses in the Latent Reservoir Increase Barrier to HIV-1 Cure, Cell, vol.155, issue.3, pp.540-551, 2013.
DOI : 10.1016/j.cell.2013.09.020

G. Laird, C. Bullen, D. Rosenbloom, A. Martin, A. Hill et al., Ex vivo analysis identifies effective HIV-1 latency???reversing drug combinations, Journal of Clinical Investigation, vol.125, issue.5, 1901.
DOI : 10.1172/JCI80142DS1

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4463209

G. Darcis, A. Kula, S. Bouchat, K. Fujinaga, F. Corazza et al., An In-Depth Comparison of Latency-Reversing Agent Combinations in Various In Vitro and Ex Vivo HIV-1 Latency Models Identified Bryostatin-1+JQ1 and Ingenol-B+JQ1 to Potently Reactivate Viral Gene Expression, PLOS Pathogens, vol.81, issue.463, p.1005063
DOI : 10.1371/journal.ppat.1005063.s009

K. Shuai and B. Liu, Regulation of JAK???STAT signalling in the immune system, Nature Reviews Immunology, vol.3, issue.11, pp.900-911, 2003.
DOI : 10.1038/nri1226

S. Williams, L. Chen, H. Kwon, D. Fenard, D. Bisgrove et al., Prostratin Antagonizes HIV Latency by Activating NF-??B, Journal of Biological Chemistry, vol.279, issue.40, pp.42008-42017, 2004.
DOI : 10.1074/jbc.M402124200

X. Contreras, M. Barboric, T. Lenasi, and B. Peterlin, HMBA Releases P-TEFb from HEXIM1 and 7SK snRNA via PI3K/Akt and Activates HIV Transcription, PLoS Pathogens, vol.14, issue.10, pp.1459-1469, 2007.
DOI : 0890-9369(2000)014[2314:TGRINB]2.0.CO;2

S. Kauder, A. Bosque, A. Lindqvist, V. Planelles, and E. Verdin, Epigenetic Regulation of HIV-1 Latency by Cytosine Methylation, PLoS Pathogens, vol.20, issue.6, 2009.
DOI : 10.1371/journal.ppat.1000495.s009

S. Bouchat, J. Gatot, K. Kabeya, C. Cardona, C. L. Herbein et al., Histone methyltransferase inhibitors induce HIV-1 recovery in resting CD4+ T cells from HIV-1-infected HAART-treated patients, AIDS, vol.26, issue.12, pp.1473-1482, 2012.
DOI : 10.1097/QAD.0b013e32835535f5

N. Archin, A. Espeseth, D. Parker, M. Cheema, D. Hazuda et al., Expression of Latent HIV Induced by the Potent HDAC Inhibitor Suberoylanilide Hydroxamic Acid, AIDS Research and Human Retroviruses, vol.25, issue.2, pp.207-212, 2009.
DOI : 10.1089/aid.2008.0191

O. Connell, K. Brennan, T. Bailey, J. Ray, S. Siliciano et al., Control of HIV-1 in Elite Suppressors despite Ongoing Replication and Evolution in Plasma Virus, Journal of Virology, vol.84, issue.14, pp.7018-7028, 2010.
DOI : 10.1128/JVI.00548-10

F. Pereyra, M. Addo, D. Kaufmann, Y. Liu, T. Miura et al., Genetic and Immunologic Heterogeneity among Persons Who Control HIV Infection in the Absence of Therapy, The Journal of Infectious Diseases, vol.197, issue.4, pp.563-571, 2008.
DOI : 10.1086/526786

A. Saez-cirion, C. Bacchus, L. Hocqueloux, V. Avettand-fenoel, I. Girault et al., Post-Treatment HIV-1 Controllers with a Long-Term Virological Remission after the Interruption of Early Initiated Antiretroviral Therapy ANRS VISCONTI Study, PLoS Pathogens, vol.22, issue.16, p.1003211, 2013.
DOI : 10.1371/journal.ppat.1003211.s007

URL : https://hal.archives-ouvertes.fr/pasteur-01420534

B. Julg, K. Williams, S. Reddy, K. Bishop, Y. Qi et al., Enhanced Anti-HIV Functional Activity Associated with Gag-Specific CD8 T-Cell Responses, Journal of Virology, vol.84, issue.11, pp.5540-554902031, 2010.
DOI : 10.1128/JVI.02031-09

T. Crowell, K. Gebo, J. Blankson, P. Korthuis, B. Yehia et al., Hospitalization Rates and Reasons Among HIV Elite Controllers and Persons With Medically Controlled HIV Infection, Journal of Infectious Diseases, vol.211, issue.11, pp.1692-1702, 2015.
DOI : 10.1093/infdis/jiu809

H. Hatano, S. Yukl, A. Ferre, E. Graf, M. Somsouk et al., Prospective Antiretroviral Treatment of Asymptomatic, HIV-1 Infected Controllers, PLoS Pathogens, vol.3, issue.10, p.1003691, 2013.
DOI : 10.1371/journal.ppat.1003691.t001

F. Boufassa, A. Saez-cirion, J. Lechenadec, D. Zucman, V. Avettand-fenoel et al., CD4 Dynamics over a 15 Year-Period among HIV Controllers Enrolled in the ANRS French Observatory, PLoS ONE, vol.4, issue.9, 2011.
DOI : 10.1371/journal.pone.0018726.t002

URL : https://hal.archives-ouvertes.fr/pasteur-01420582

T. Chun, J. Justement, D. Murray, C. Kim, J. Blazkova et al., Effect of Antiretroviral Therapy on HIV Reservoirs in Elite Controllers, Journal of Infectious Diseases, vol.208, issue.9, pp.1443-1447, 2013.
DOI : 10.1093/infdis/jit306

D. Persaud and K. Luzuriaga, Absence of HIV-1 after treatment cessation in an infant, N Engl J Med, vol.370, p.678, 2014.

Z. Ndhlovu, E. Stampouloglou, K. Cesa, O. Mavrothalassitis, D. Alvino et al., ABSTRACT, Journal of Virology, vol.89, issue.21, pp.10735-1074701527, 2015.
DOI : 10.1128/JVI.01527-15

M. Nasi, M. Pinti, S. Manzini, L. Gibellini, L. Manzini et al., Patients, AIDS Research and Human Retroviruses, vol.26, issue.5, pp.553-558, 2010.
DOI : 10.1089/aid.2009.0256

C. Goujard, M. Bonarek, L. Meyer, F. Bonnet, M. Chaix et al., CD4 Cell Count and HIV DNA Level Are Independent Predictors of Disease Progression after Primary HIV Type 1 Infection in Untreated Patients, Clinical Infectious Diseases, vol.42, issue.5, pp.709-715, 2006.
DOI : 10.1086/500213

C. Rouzioux, J. Hubert, M. Burgard, C. Deveau, C. Goujard et al., T Cell Counts, The Journal of Infectious Diseases, vol.192, issue.1, pp.46-55, 2005.
DOI : 10.1086/430610

URL : https://hal.archives-ouvertes.fr/pasteur-01420524

M. Kiselinova, D. Spiegelaere, W. Buzon, M. Malatinkova, E. Lichterfeld et al., Integrated and total HIV-1 DNA predict ex vivo viral outgrowth, PLoS Pathog, vol.12, 2016.
DOI : 10.1371/journal.ppat.1005472

URL : http://doi.org/10.1371/journal.ppat.1005472

J. Leng, H. Ho, M. Buzon, F. Pereyra, B. Walker et al., A Cell-Intrinsic Inhibitor of HIV-1 Reverse Transcription in CD4+ T Cells from Elite Controllers, Cell Host & Microbe, vol.15, issue.6, pp.717-728, 2014.
DOI : 10.1016/j.chom.2014.05.011

R. Buckheit, I. Allen, T. Alme, A. Salgado, M. et al., Host factors dictate control of viral replication in two HIV-1 controller/chronic progressor transmission pairs, Nature Communications, vol.78, p.716, 2012.
DOI : 10.1038/ncomms1697