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A. Acknowledgments-we-acknowledge, P. Haouz, S. Weber, P. Lopez-fernandez, and . Arrasate, Structural Glycobiology Group, Unit of Biophysics, Spain) for technical assistance; and the European Synchrotron Radiation Facility (ESRF), the French National Synchrotron SOLEIL, the Diamond Light Source (DLS) and the Swiss Light Source (SLS) for granting access to synchrotron radiation facilities and their staff for the onsite assistance. We specially thank the BioStruct-X project to support access to structural biology facilities. Technical support provided by Universidad del País Vasco/Euskal Herriko Unibertsitatea and Ministerio de Ciencia e Innovación is acknowledged. We also thank all members of the Structural Glycobiology Group for valuable scientific discussions. This work was supported by the European Community's Sixth and Seventh Framework Programmes (contracts LSHP-CT-2005-018923 and HEALTH-F3, the Institut Pasteur, the Spanish Ministry of Science and Innovation (contracts SAF2010-19096 and BIO2013-49022-C2-2-R), IKERBASQUE, the Basque Foundation for Science, the Basque Government and the Fundación Biofísica Bizkaia, 2011.

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