D. Bell-pedersen, G. Salvo, J. Belfort, and M. , A transcription terminator in the thymidylate synthase (thyA) structural gene of Escherichia coli and construction of a viable thyA::Kmr deletion., Journal of Bacteriology, vol.173, issue.3, pp.1193-1200, 1991.
DOI : 10.1128/jb.173.3.1193-1200.1991

R. Bishop, H. Gibbons, T. Guina, M. Trent, S. Miller et al., Transfer of 765 palmitate from phospholipids to lipid A in outer membranes of gram-negative bacteria, p.766, 2000.

M. Bos, B. Tefsen, J. Geurtsen, and J. Tommassen, Identification of an outer 769 membrane protein required for the transport of lipopolysaccharide to the bacterial cell 770 surface, Proceedings of the National Academy of Sciences of the United States of America, vol.771, issue.101, pp.9417-9422, 2004.

V. Braun and K. Rehn, Chemical characterization, spatial distribution and function of 774 a lipoprotein (murein-lipoprotein) of the E. coli cell wall. European journal of 775 biochemistry, FEBS, vol.10, pp.426-438, 1969.

V. Braun and V. Bosch, Sequence of the Murein . Lipoprotein and the Attachment Site of the Lipid, European Journal of Biochemistry, vol.46, issue.1, pp.51-69, 1972.
DOI : 10.1016/S0076-6879(67)11051-3

J. Brülle, A. Tschumi, and P. Sander, Lipoproteins of slow-growing Mycobacteria 781 carry three fatty acids and are N-acylated by apolipoprotein, p.782, 2013.

P. Sander, Cloning, expression and charaterization of Mycobacterium tuberculosis 786 lipoprotein LprF, Biochem Biophys Res Comm, vol.391, pp.679-684, 2010.

J. Bubeck-wardenburg, W. Williams, and D. Missiakas, Host defenses against 789 Staphylococcus aureus infection require recognition of bacterial lipoproteins, Proc Natl, p.790, 2006.

N. Buddelmeijer and R. Young, -Acyltransferase (Lnt) Exists as an Extracytoplasmic Thioester Acyl-Enzyme Intermediate, Biochemistry, vol.49, issue.2, pp.341-346, 0794.
DOI : 10.1021/bi9020346

URL : https://hal.archives-ouvertes.fr/pasteur-01407714

J. Cain, N. Solis, and S. Cordwell, Beyond gene expression: The impact of protein post-translational modifications in bacteria, Journal of Proteomics, vol.97, pp.265-286, 2014.
DOI : 10.1016/j.jprot.2013.08.012

K. Chatzi, M. Sardis, A. Economou, and S. Karamanou, SecA-mediated targeting and translocation of secretory proteins, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, vol.1843, issue.8, pp.1466-1474, 2014.
DOI : 10.1016/j.bbamcr.2014.02.014

S. Chimalapati, J. Cohen, E. Camberlein, N. Macdonald, C. Durmort et al., Effects of Deletion of the Streptococcus pneumoniae Lipoprotein Diacylglyceryl Transferase Gene lgt on ABC Transporter Function and on Growth In Vivo, PLoS ONE, vol.53, issue.7, p.41393, 2012.
DOI : 10.1371/journal.pone.0041393.t004

S. Chng, N. Ruiz, G. Chimalakonda, T. Silhavy, and D. Kahne, Characterization of the 813 two-protein complex in Escherichia coli responsible for lipopolysaccharide assembly at 814 the outer membrane, Proceedings of the National Academy of Sciences of the United States, pp.5363-5368, 2010.

D. Choi, H. Yamada, T. Mizuno, and S. Mizushima, Trimeric structure and localization 818 of the major lipoprotein in the cell surface of Escherichia coli, J Biol Chem, vol.261, pp.8953-819, 1986.

C. Cooper, L. Hsu, S. Jackowski, and C. Rock, 2-Acylglycerolphosphoethanolamine 822 acyltransferase/acyl-acyl carrier protein synthetase is a membrane-associated acyl 823 carrier protein binding protein, The Journal of biological chemistry, vol.264, pp.7384-7389, 1989.

G. Servin-gonzalez and L. , Lipoprotein N-acyl transferase (Lnt1) is dispensable for 827 protein O-mannosylation by Streptomyces coelicolor, FEMS microbiology letters, vol.350, pp.828-72, 2014.

P. Cornelis, A. Bouia, A. Belarbi, A. Guyonvarch, B. Kammerer et al., Cloning and analysis of the gene for the major outer membrane lipoprotein from 832, 1989.

P. Cornelis, J. Cote-sierra, L. Jr, and A. , Development of new cloning vectors for 835 the production of immunogenic outer membrane fusion proteins in Escherichia coli, p.836, 1996.

L. Coutte, E. Willery, R. Antoine, H. Drobecq, C. Locht et al., Surface 839 anchoring of bacterial subtilisin important for maturation function, Mol Microbiol, vol.49, pp.840-529, 2003.

L. Coutte, S. Alonso, N. Reveneau, E. Willery, B. Quatannens et al., Role of adhesin release for mucosal colonization by a bacterial pathogen. The 844, Journal of experimental medicine, vol.843, issue.197, pp.735-742, 2003.

C. Cowles, Y. Li, M. Semmelhack, I. Cristea, and T. Silhavy, The free and bound 847 forms of Lpp occupy distinct subcellular locations in Escherichia coli, Molecular 848 microbiology, pp.1168-1181, 2011.

J. Cronan, J. Rock, and C. , Biosynthesis of membrane lipids, p.851, 1996.

S. Das, T. Kanamoto, X. Ge, P. Xu, T. Unoki et al., Contribution of Lipoproteins and Lipoprotein Processing to Endocarditis Virulence in Streptococcus sanguinis, Journal of Bacteriology, vol.191, issue.13, pp.4166-4179, 2009.
DOI : 10.1128/JB.01739-08

D. Bona, P. Deshmukh, L. Gorbatyuk, V. Vinogradova, O. Kendall et al., Structural studies of a signal peptide in complex with signal peptidase I cytoplasmic domain: The stabilizing effect of membrane-mimetics on the acquired fold, Proteins: Structure, Function, and Bioinformatics, vol.273, issue.3, pp.807-817, 2012.
DOI : 10.1002/prot.23238

E. Denham, P. Ward, and J. Leigh, In the absence of Lgt, lipoproteins are shed 867 from Streptococcus uberis independently of Lsp, Microbiology, vol.155, pp.868-134, 2009.

I. Dev, R. Harvey, and P. Ray, Inhibition of prolipoprotein signal peptidase by 871 globomycin, J Biol Chem, vol.260, pp.5891-5894, 1985.

L. Dietrich and C. Ungermann, On the mechanism of protein palmitoylation, EMBO reports, vol.1436, issue.11, pp.1053-1057, 2004.
DOI : 10.1074/jbc.M209760200

W. Doerrler and C. Raetz, ATPase Activity of the MsbA Lipid Flippase of Escherichia coli, Journal of Biological Chemistry, vol.277, issue.39, pp.36697-36705, 2002.
DOI : 10.1074/jbc.M205857200

W. Doerrler, M. Reedy, and C. Raetz, An Escherichia coli Mutant Defective in Lipid Export, Journal of Biological Chemistry, vol.276, issue.15, pp.11461-11464, 2001.
DOI : 10.1074/jbc.C100091200

W. Doerrler, H. Gibbons, and C. Raetz, MsbA-dependent translocation of lipids 883 across the inner membrane of Escherichia coli, The Journal of biological chemistry, vol.279, pp.884-45102, 2004.

O. Doi and S. Nojima, Lysophospholipase of Escherichia coli. The Journal of biological 887, chemistry, vol.250, pp.5208-5214, 1975.

R. Doshi and H. Van-veen, Substrate binding stabilizes a pre-translocation 890 intermediate in the ATP-binding cassette transport protein MsbA. The Journal of 891 biological chemistry, pp.21638-21647, 2013.

E. Erez, D. Fass, and E. Bibi, How intramembrane proteases bury hydrolytic reactions in the membrane, Nature, vol.281, issue.7245, pp.371-378, 2009.
DOI : 10.1038/nature08146

C. Espitia and R. Mancilla, Identification, isolation and partial characterization of 897 Mycobacterium tuberculosis glycoprotein antigens, Clinical and experimental, vol.898, issue.77, pp.378-383, 1989.

W. Fischer, Lipoteichoic acid and lipids in the membrane of Staphylococcus aureus, Medical Microbiology and Immunology, vol.173, issue.2, pp.61-76, 1994.
DOI : 10.1007/BF00277157

E. Freinkman, S. Chng, and D. Kahne, The complex that inserts lipopolysaccharide 904 into the bacterial outer membrane forms a two-protein plug-and-barrel, Proceedings of 905 the National Academy of Sciences of the United States of America, pp.2486-2491, 2011.

K. Gan, S. Gupta, K. Sankaran, M. Schmid, and H. Wu, Isolation and characterization 913 of a temperature-sensitive mutant of Salmonella typhimurium defective in 914 prolipoprotein modification, J Biol Chem, vol.268, pp.16544-16550, 1993.

K. Gan, K. Sankaran, M. Williams, M. Aldea, K. Rudd et al., The umpA gene of Escherichia coli encodes phosphatidylglycerol:prolipoprotein diacylglyceryl transferase (lgt) and regulates thymidylate synthase levels through translational coupling., Journal of Bacteriology, vol.177, issue.7, pp.1879-1882, 1995.
DOI : 10.1128/jb.177.7.1879-1882.1995

G. Besra, Disruption of Cg-Ppm1, a polyprenyl monophosphomannose synthase, 927 and the generation of lipoglycan-less mutants in Corynebacterium glutamicum, J Biol 928 Chem, vol.278, pp.40842-40850, 2003.

M. Gimenez, K. Dilks, and M. Pohlschroder, Haloferax volcanii twin-arginine translocation substates include secreted soluble, C-terminally anchored and lipoproteins, Molecular Microbiology, vol.20, issue.6, pp.1597-1606, 2007.
DOI : 10.1111/j.1365-2958.2007.06034.x

M. Gonzalez-zamorano, G. Mendoza-hernandez, W. Xolalpa, C. Parada, and A. Vallecillo, Glycoproteomics Based on ConA-Lectin Affinity Capture of Mannosylated Proteins, Journal of Proteome Research, vol.8, issue.2, pp.721-733
DOI : 10.1021/pr800756a

S. Gullon, E. Arranz, and R. Mellado, Transcriptional characterisation of the negative effect exerted by a deficiency in type II signal peptidase on extracellular protein secretion in Streptomyces lividans, Applied Microbiology and Biotechnology, vol.80, issue.2, pp.10069-941, 2013.
DOI : 10.1007/s00253-013-5219-9

M. Guo, T. Updegrove, E. Gogol, S. Shabalina, C. Gross et al., MicL, a new ??E-dependent sRNA, combats envelope stress by repressing synthesis of Lpp, the major outer membrane lipoprotein, Genes & Development, vol.28, issue.14, pp.1620-1634, 2014.
DOI : 10.1101/gad.243485.114

S. Gupta, W. Dowham, and H. Wu, Phosphatidylethanolamine is not essential for 951 the N-acylation of apolipoprotein in Escherichia coli, J Biol Chem, vol.266, pp.9983-9986, 1991.

S. Gupta, K. Gan, M. Schmid, and H. Wu, Characterization of a temperature- 954 sensitive mutant of Salmonella typhimurium defective in apolipoprotein N- 955 acyltransferase, J Biol Chem, vol.268, pp.16551-16556, 1993.

S. Gurcha, A. Baulard, L. Kremer, C. Locht, D. Moody et al., Ppm1, a novel polyprenol monophosphomannose synthase from Mycobacterium tuberculosis, Biochemical Journal, vol.365, issue.2, pp.441-450, 2002.
DOI : 10.1042/bj20020107

D. Haake, Spirochaetal lipoproteins and pathogenesis. Microbiology (Reading, pp.1491-1504, 2000.
DOI : 10.1099/00221287-146-7-1491

A. Waller and D. Harrington, Mutation of the maturase lipoprotein attenuates the 966 virulence of Streptococcus equi to a greater extent than does loss of general lipoprotein 967 lipidation, Infect Immun, vol.74, pp.6907-6919, 2006.

K. Hantke and V. Braun, Covalent Binding of Lipid to Protein, European Journal of Biochemistry, vol.35, issue.2, pp.284-296, 1973.
DOI : 10.1111/j.1432-1033.1973.tb02757.x

S. Hayashi and H. Wu, Biosynthesis of Bacillus licheniformis penicillinase in 979 Escherichia coli and in Bacillus subtilis, Journal of bacteriology, vol.156, pp.773-777, 1983.

S. Hayashi and H. Wu, Accumulation of prolipoprotein in Escherichia coli mutants 982 defective in protein secretion, Journal of bacteriology, vol.164, pp.949-954, 1985.

S. Hayashi, S. Chang, S. Chang, C. Giam, and H. Wu, Modification and processing of 985 internalized signal sequences of prolipoprotein in Escherichia coli and in Bacillus subtilis, J Biol Chem, vol.260, pp.5753-5759, 1985.

P. Henneke, S. Dramsi, and G. Mancuso, Lipoproteins Are Critical TLR2 Activating Toxins in Group B Streptococcal Sepsis, The Journal of Immunology, vol.180, issue.9, pp.6149-6158, 2008.
DOI : 10.4049/jimmunol.180.9.6149

URL : https://hal.archives-ouvertes.fr/hal-00276062

J. Herrmann, O. Gaora, P. Gallagher, A. Thole, J. Young et al., Bacterial 992 glycoproteins: a link between glycosylation and proteolytic cleavage of a 19 kDa antigen 993 from Mycobacterium tuberculosis, EMBO J, vol.15, pp.3547-3554, 1996.

H. Hiemstra, M. De-hoop, M. Inouye, and B. Witholt, Induction kinetics and cell surface 996 distribution of Escherichia coli lipoprotein under lac promoter control, Journal, vol.997, issue.168, pp.140-151, 1986.

H. Hiemstra, N. Nanninga, and C. Woldringh, Distribution of newly synthesized lipoprotein over the outer membrane and the peptidoglycan sacculus of an Escherichia coli lac-lpp strain., Journal of Bacteriology, vol.169, issue.12, pp.5434-5444, 1987.
DOI : 10.1128/jb.169.12.5434-5444.1987

F. Hillmann, M. Argentini, and N. Buddelmeijer, -Acyltransferase, Journal of Biological Chemistry, vol.286, issue.32, pp.27936-27946, 2011.
DOI : 10.1074/jbc.M111.243519

URL : https://hal.archives-ouvertes.fr/hal-00604405

Y. Hirota, H. Suzuki, Y. Nishimura, and S. Yasuda, On the process of cellular division in 1007, 1977.

. Escherichia-coli, A mutant of E. coli lacking a murein-lipoprotein, Proc Natl Acad Sci, vol.74, pp.1417-1420, 1008.

T. Nogi, A structure-based model of substrate discrimination by a noncanonical 1012 PDZ tandem in the intramembrane-cleaving protease RseP, Structure, vol.22, pp.326-336, 2014.

H. Homma and S. Nojima, Synthesis of Various Phospholipids from 2-Acyl Lysophospholipids by Escherichia Coli Extract1, The Journal of Biochemistry, vol.91, issue.4, pp.1103-1110, 1982.
DOI : 10.1093/oxfordjournals.jbchem.a133792

L. Hsu, S. Jackowski, and C. Rock, Isolation and characterization of Escherichia coli K- 1018 12 mutants lacking both 2-acylglycerophosphoethanolamine acyltransferase and acyl- 1019 acyl carrier protein synthetase activity, J Biol Chem, vol.266, pp.13783-13788, 1991.

J. Hu, Y. Xue, S. Lee, and Y. Ha, The crystal structure of GXGD membrane protease FlaK, Nature, vol.10, issue.7357, pp.528-531, 1022.
DOI : 10.1038/nature10218

M. Hussain, S. Ichihara, and S. Mizushima, Accumulation of glyceride-containing 1025 precursor of the outer membrane lipoprotein in the cytoplasmic membrane of 1026 Escherichia coli treated with globomycin, J Biol Chem, vol.255, pp.3707-3712, 1980.

M. Hussain, S. Ichihara, and S. Mizushima, Mechanism of signal peptide cleavage in the 1029 biosynthesis of the major lipoprotein of the Escherichia coli outer membrane, J Biol Chem, vol.257, pp.5177-5182, 1030.

S. Ichihara, T. Suzuki, M. Suzuki, and S. Mizushima, Molecular cloning and sequencing 1033 of the sppA gene and characterization of the encoded protease IV, a signal peptide 1034 peptidase, of Escherichia coli, The Journal of biological chemistry, vol.261, pp.9405-9411, 1986.

M. Inouye, J. Shaw, and C. Shen, The assembly of a structural lipoprotein in the 1037 envelope of Escherichia coli, The Journal of biological chemistry, vol.247, pp.8154-8159, 1972.

S. Inouye, G. Vlasuk, H. Hsiung, and M. Inouye, Effects of mutations at glycine 1040 residues in the hydrophobic region of the Escherichia coli prolipoprotein signal peptide 1041 on the secretion across the membrane, The Journal of biological chemistry, vol.259, pp.3729-1042, 1984.

S. Inouye, S. Wang, J. Sekizawa, S. Halegoua, and M. Inouye, Amino acid sequence for the peptide extension on the prolipoprotein of the Escherichia coli outer membrane., Proceedings of the National Academy of Sciences, vol.74, issue.3, pp.1004-1047, 1046.
DOI : 10.1073/pnas.74.3.1004

M. Inukai, K. Takeuchi, K. Shimizu, and M. Arai, Mechanism of action of globomycin., The Journal of Antibiotics, vol.31, issue.11, pp.1203-1205, 1978.
DOI : 10.7164/antibiotics.31.1203

M. Inukai, R. Enokita, A. Torikata, and M. Nakahara, Globomycin, a new peptide antibiotic with spheroplast-forming activity. I. Taxonomy of producing organisms and fermentation., The Journal of Antibiotics, vol.31, issue.5, pp.410-420, 1978.
DOI : 10.7164/antibiotics.31.410

M. Inukai, M. Nakajima, M. Osawa, T. Haneishi, and M. Arai, Globomycin, a new peptide antibiotic with spheroplast-forming activity. II. Isolation and physico-chemical and biological characterization., The Journal of Antibiotics, vol.31, issue.5, pp.421-425, 1978.
DOI : 10.7164/antibiotics.31.421

H. Ito, A. Ura, Y. Oyamada, H. Yoshida, J. Yamagishi et al., A New Screening Method to Identify Inhibitors of the Lol (Localization of lipoproteins) System, a Novel Antibacterial Target, Microbiology and Immunology, vol.53, issue.3, pp.263-1063, 2007.
DOI : 10.1111/j.1348-0421.2007.tb03906.x

S. Ivanov, G. Charron, H. Hang, and C. Roy, Lipidation by the Host Prenyltransferase Machinery Facilitates Membrane Localization of Legionella pneumophila Effector Proteins, Journal of Biological Chemistry, vol.285, issue.45, pp.34686-34698, 2010.
DOI : 10.1074/jbc.M110.170746

S. Jackowski and C. Rock, Transfer of fatty acids from the 1-position of 1070 phosphatidylethanolamine to the major outer membrane lipoprotein of Escherichia coli, J Biol Chem, vol.261, pp.11328-11333, 1071.

S. Jackowski, P. Jackson, and C. Rock, Sequence and function of the aas gene in 1074 Escherichia coli, The Journal of biological chemistry, vol.269, pp.2921-2928, 1994.

G. Jan, C. Fontenelle, L. Henaff, M. Wroblewski, and H. , Acylation and immunological properties of Mycoplasma gallisepticum membrane proteins, Research in Microbiology, vol.146, issue.9, pp.739-750, 1078.
DOI : 10.1016/0923-2508(96)81070-9

M. Jin, S. Kim, J. Heo, M. Lee, H. Kim et al., Crystal Structure of the TLR1-TLR2 Heterodimer Induced by Binding of a Tri-Acylated Lipopeptide, Cell, vol.130, issue.6, pp.1071-1082, 1082.
DOI : 10.1016/j.cell.2007.09.008

K. Kanehara, Y. Akiyama, and K. Ito, Characterization of the yaeL gene product and its S2P-protease motifs in Escherichia coli, Gene, vol.281, issue.1-2, pp.71-79, 2001.
DOI : 10.1016/S0378-1119(01)00823-X

T. Kiho, M. Nakayama, K. Yasuda, S. Miyakoshi, M. Inukai et al., Synthesis and antimicrobial activity of novel globomycin analogues, Bioorganic & Medicinal Chemistry Letters, vol.13, issue.14, pp.2315-1093, 2003.
DOI : 10.1016/S0960-894X(03)00432-3

T. Kiho, M. Nakayama, K. Yasuda, S. Miyakoshi, M. Inukai et al., Structure- 1096 activity relationships of globomycin analogues as antibiotics, Bioorganic & medicinal 1097 chemistry, pp.337-361, 2004.

A. Kim, D. Oliver, and M. Paetzel, Crystal Structure of a Bacterial Signal Peptide Peptidase, Journal of Molecular Biology, vol.376, issue.2, pp.352-366, 2008.
DOI : 10.1016/j.jmb.2007.11.080

A. Kovacs-simon, R. Titball, and S. Michell, Lipoproteins of Bacterial Pathogens, Infection and Immunity, vol.79, issue.2, pp.548-561, 1103.
DOI : 10.1128/IAI.00682-10

D. Kuo, H. Chan, C. Wilson, P. Griffin, H. Williams et al., Escherichia coli Leader Peptidase: Production of an Active Form Lacking a Requirement for Detergent and Development of Peptide Substrates, Archives of Biochemistry and Biophysics, vol.303, issue.2, pp.274-1108, 1993.
DOI : 10.1006/abbi.1993.1283

K. Kurokawa, K. Ryu, and R. Ichikawa, Novel bacterial lipoprotein structures 1115 conserved in low-GC content Gram-positive bacteria are recognized by Toll-like receptor 1116, 2012.

O. Takeuchi, H. J. Kang, N. Dohmae, Y. Nakanishi, S. Akira et al., The 1120 triacylated ATP binding cluster transporter substrate-binding lipoprotein of 1121 Staphylococcus aureus functions as a native ligand for Toll-like receptor 2, J Biol Chem, vol.284, pp.8406-8411, 1122.

J. Lai, W. &. Philbrick, and H. Wu, Acyl moieties in phospholipids are tha precursors 1125 for the fatty acids in murein lipoprotein in Escherichia coli, J Biol Chem, vol.255, pp.5384-5387, 1980.

C. Lapointe and R. Taylor, The Type 4 Prepilin Peptidases Comprise a Novel Family of Aspartic Acid Proteases, Journal of Biological Chemistry, vol.275, issue.2, pp.1502-1510, 2000.
DOI : 10.1074/jbc.275.2.1502

S. Leskelä, E. Wahlström, V. P. Sarvas, and M. , Lipid modification of prelipoproteins is dispensable for growth but essential for efficient protein secretion in Bacillus subtilis: characterization of the lgt gene, Molecular Microbiology, vol.79, issue.4, pp.1075-1085, 1999.
DOI : 10.1016/0378-1097(94)90310-7

J. Lin, H. Kanazawa, J. Ozols, and H. Wu, An Escherichia coli mutant with an amino 1135 acid alteration within the signal sequence of outer membrane prolipoprotein, Proc Natl, p.1136, 1978.

J. Lin, C. Giam, and H. Wu, Assembly of the outer membrane lipoprotein in 1139 Escherichia coli, The Journal of biological chemistry, vol.255, pp.807-811, 1980.

P. Lu, X. Bai, and D. Ma, Three-dimensional structure of human ??-secretase, Nature, vol.68, issue.7513, pp.166-170, 2014.
DOI : 10.1038/nature13567

M. Babu, M. Sankaran, and K. , DOLOP--database of bacterial lipoproteins, Bioinformatics, vol.18, issue.4, pp.641-643, 1149.
DOI : 10.1093/bioinformatics/18.4.641

S. Magnet, L. Dubost, M. A. Arthur, M. Gutmann, and L. , Identification of the L,D- 1152 transpeptidases for peptidoglycan cross-linking in Escherichia coli, Journal, vol.190, pp.4782-4785, 1153.

S. Magnet, A. Arbeloa, and J. Mainardi, Specificity of L,D-transpeptidases from 1156 gram-positive bacteria producing different peptidoglycan chemotypes. The Journal of 1157 biological chemistry, pp.13151-13159, 2007.

L. Gutmann and M. Arthur, A novel peptidoglycan cross-linking enzyme for a beta- 1161 lactam-resistant transpeptidation pathway, The Journal of biological chemistry, vol.280, pp.1162-38146, 2005.

G. Malojcic, D. Andres, M. Grabowicz, A. George, N. Ruiz et al., LptE 1169 binds to and alters the physical state of LPS to catalyze its assembly at the cell surface, Proceedings of the National Academy of Sciences of the United States of America, vol.111, pp.1171-9467, 1170.

L. Wright and M. Pichichero, Dual orientation of the outer membrane lipoprotein 1175 P6 of nontypeable haemophilus influenzae, Journal of bacteriology, vol.195, pp.3252-3259, 2013.

D. Mitchell, G. Mitchell, Y. Ling, C. Budde, and R. Deschenes, Mutational Analysis of Saccharomyces cerevisiae Erf2 Reveals a Two-step Reaction Mechanism for Protein Palmitoylation by DHHC Enzymes, Journal of Biological Chemistry, vol.285, issue.49, pp.38104-1180, 2010.
DOI : 10.1074/jbc.M110.169102

M. Paetzel, A. Karla, N. Strynadka, and R. Dalbey, Signal peptidases, Chem Rev, vol.102, pp.1238-4549, 2002.
DOI : 10.1021/cr010166y

C. Paradis-bleau, M. Markovski, T. Uehara, T. Lupoli, S. Walker et al., Lipoprotein cofactors located in the outer membrane activate bacterial cell wall 1247 polymerases, Cell, vol.1246, issue.143, pp.1110-1120, 2010.

J. Parsons and C. Rock, Bacterial lipids: Metabolism and membrane homeostasis, Progress in Lipid Research, vol.52, issue.3, pp.249-276, 1250.
DOI : 10.1016/j.plipres.2013.02.002

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3665635

R. Patel, S. Smith, and C. Robinson, Protein transport by the bacterial Tat pathway, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, vol.1843, issue.8, pp.1620-1628, 1253.
DOI : 10.1016/j.bbamcr.2014.02.013

F. Capretta and E. Brown, Chemical genomics in Escherichia coli identifies an 1257 inhibitor of bacterial lipoprotein targeting, Nature chemical biology, vol.5, pp.849-856, 2009.

S. Pollitt, S. Inouye, and M. Inouye, A functional prolipoprotein signal peptide with a 1264 deletion of four amino acid residues from the hydrophobic region. The Journal of 1265 biological chemistry, pp.7965-7969, 1985.

Z. Pragai, H. Tjalsma, A. Bolhuis, J. Van-dijl, G. Venema et al., The signal peptidase II (Isp) gene of Bacillus subtilis, Microbiology, vol.143, issue.4, pp.1327-1333, 1997.
DOI : 10.1099/00221287-143-4-1327

A. Pugsley, C. Chapon, and M. Schwartz, Extracellular pullulanase of Klebsiella pneumoniae is a lipoprotein., Journal of Bacteriology, vol.166, issue.3, pp.1083-1088, 1986.
DOI : 10.1128/jb.166.3.1083-1088.1986

H. Qi, K. Sankaran, K. Gan, and H. Wu, Structure-function relationship of bacterial prolipoprotein diacylglyceryl transferase: functionally significant conserved regions., Journal of Bacteriology, vol.177, issue.23, pp.6820-6824, 1995.
DOI : 10.1128/jb.177.23.6820-6824.1995

C. Raetz, Molecular genetics of membrane phospholipid synthesis. Annual review 1278 of genetics, pp.253-295, 1986.

S. Rampini, P. Selchow, C. Keller, S. Ehlers, E. Bottger et al., LspA inactivation in Mycobacterium tuberculosis results in attenuation without affecting phagosome maturation arrest, Microbiology, vol.154, issue.10, pp.2991-3001, 2008.
DOI : 10.1099/mic.0.2008/018895-0

A. Rana, A. Singh, S. Gurcha, L. Cox, A. Bhatt et al., Ppm1-Encoded Polyprenyl Monophosphomannose Synthase Activity Is Essential for Lipoglycan Synthesis and Survival in Mycobacteria, PLoS ONE, vol.33, issue.10, p.48211, 2012.
DOI : 10.1371/journal.pone.0048211.g006

K. Decanniere and P. Van-gelder, Hydrophobic surface patches on LolA of 1294 Pseudomonas aeruginosa are essential for lipoprotein binding, Journal of molecular 1295 biology, vol.401, pp.921-930, 2010.

C. Robichon, D. Vidal-ingigliardi, and A. Pugsley, Depletion of Apolipoprotein N-Acyltransferase Causes Mislocalization of Outer Membrane Lipoproteins in Escherichia coli, Journal of Biological Chemistry, vol.280, issue.2, pp.974-983, 2005.
DOI : 10.1074/jbc.M411059200

S. Rogers, M. Bhave, J. Mercer, J. Camakaris, and B. Lee, Cloning and characterization of cutE, a gene involved in copper transport in Escherichia coli., Journal of Bacteriology, vol.173, issue.21, pp.6742-6748, 1991.
DOI : 10.1128/jb.173.21.6742-6748.1991

E. Rosenberg, B. Vaks, and A. Zuckerberg, Bactericidal Action of an Antibiotic Produced by Myxococcus xanthus, Antimicrobial Agents and Chemotherapy, vol.4, issue.5, pp.507-513, 1973.
DOI : 10.1128/AAC.4.5.507

V. Roussel-jazede, J. Grijpstra, V. Van-dam, J. Tommassen, and P. Van-ulsen, Lipidation of the autotransporter NalP of Neisseria meningitidis is required for its function in the release of cell-surface-exposed proteins, Microbiology, vol.159, issue.Pt_2, pp.286-295, 2013.
DOI : 10.1099/mic.0.063982-0

N. Ruiz, D. Kahne, and T. Silhavy, Transport of lipopolysaccharide across the cell 1313 envelope: the long road of discovery, Nature reviews, vol.7, pp.677-683, 2009.

P. Sander, M. Rezwan, and B. Walker, Lipoprotein processing is required for virulence of Mycobacterium tuberculosis???, Molecular Microbiology, vol.142, issue.6, pp.1543-1552, 2004.
DOI : 10.1111/j.1365-2958.2004.04041.x

K. Sankaran and H. Wu, Lipid modification of bacterial prolipoprotein. Transfer of 1323 diacylglyceryl moiety from phosphatidylglycerol, J Biol Chem, vol.269, pp.19701-19706, 1994.

K. Sankaran, K. Gan, B. Rash, H. Qi, H. Wu et al., Roles of histidine-103 and tyrosine-235 in the function of the prolipoprotein diacylglyceryl transferase of Escherichia coli., Journal of Bacteriology, vol.179, issue.9, pp.2944-2948, 1997.
DOI : 10.1128/jb.179.9.2944-2948.1997

M. Sartain and J. Belisle, N-Terminal clustering of the O-glycosylation sites in the Mycobacterium tuberculosis lipoprotein SodC, Glycobiology, vol.19, issue.1, pp.38-51, 2009.
DOI : 10.1093/glycob/cwn102

C. Sassetti, D. Boyd, and E. Rubin, Genes required for mycobacterial growth defined by high density mutagenesis, Molecular Microbiology, vol.1, issue.Suppl 1), pp.77-84, 2003.
DOI : 10.1046/j.1365-2958.2003.03425.x

A. Selvan and K. Sankaran, Localization and characterization of prolipoprotein diacylglyceryl transferase (Lgt) critical in bacterial lipoprotein biosynthesis, Biochimie, vol.90, issue.11-12, pp.1647-1655, 1337.
DOI : 10.1016/j.biochi.2008.06.005

M. Serebryakova, I. Demina, M. Galyamina, I. Kondratov, V. Ladygina et al., The Acylation State of Surface Lipoproteins of Mollicute Acholeplasma laidlawii, Journal of Biological Chemistry, vol.286, issue.26, p.1340, 1341.
DOI : 10.1074/jbc.M111.231316

H. Shruthi, P. Anand, V. Murugan, and K. Sankaran, Twin arginine translocase pathway and fast-folding lipoprotein biosynthesis in E. coli: interesting implications and applications, Molecular BioSystems, vol.269, issue.6, pp.999-1007, 2010.
DOI : 10.1039/b916510j

W. Shu, J. Liu, H. Ji, and M. Lu, Core structure of the outer membrane lipoprotein from Escherichia coli at 1.9 ?? resolution, Journal of Molecular Biology, vol.299, issue.4, pp.1101-1112, 2000.
DOI : 10.1006/jmbi.2000.3776

I. Siboo and D. Chaffin, Characterization of the Accessory Sec System of Staphylococcus aureus, Journal of Bacteriology, vol.190, issue.18, pp.6188-6196, 2008.
DOI : 10.1128/JB.00300-08

H. Stoll, J. Dengjel, C. Nerz, and F. Gotz, Staphylococcus aureus Deficient in Lipidation of Prelipoproteins Is Attenuated in Growth and Immune Activation, Infection and Immunity, vol.73, issue.4, pp.2411-1355, 2005.
DOI : 10.1128/IAI.73.4.2411-2423.2005

S. Storf, F. Pfeiffer, K. Dilks, Z. Chen, S. Imam et al., Mutational and 1358 bioinformatic analysis of haloarchaeal lipobox-containing proteins, Archaea, 2010.

M. Strom and S. Lory, Mapping of export signals of Pseudomonas aeruginosa pilin with alkaline phosphatase fusions., Journal of Bacteriology, vol.169, issue.7, pp.3181-3188, 1987.
DOI : 10.1128/jb.169.7.3181-3188.1987

S. Sundaram, S. Banerjee, and K. Sankaran, The first nonradioactive fluorescence assay for phosphatidylglycerol:prolipoprotein diacylglyceryl transferase that initiates bacterial lipoprotein biosynthesis, Analytical Biochemistry, vol.423, issue.1, pp.163-170, 2012.
DOI : 10.1016/j.ab.2012.01.018

I. Sutcliffe and D. Harrington, Pattern searches for the identification of putative lipoprotein genes in Gram-positive bacterial genomes, Microbiology, vol.148, issue.7, pp.2065-2077, 1369.
DOI : 10.1099/00221287-148-7-2065

K. Takeda, H. Miyatake, N. Yokota, S. Matsuyama, H. Tokuda et al., Crystal structures of bacterial lipoprotein localization factors, LolA and LolB, The EMBO Journal, vol.22, issue.13, pp.3199-1377, 2003.
DOI : 10.1093/emboj/cdg324

N. Taniguchi, S. Matsuyama, and H. Tokuda, Mechanisms Underlying Energy-independent Transfer of Lipoproteins from LolA to LolB, Which Have Similar Unclosed ??-Barrel Structures, Journal of Biological Chemistry, vol.280, issue.41, pp.34481-34488, 2005.
DOI : 10.1074/jbc.M507388200

B. Thompson, D. Widdick, M. Hicks, G. Chandra, I. Sutcliffe et al., Investigating lipoprotein biogenesis and function in the model Gram-positive 1385 bacterium Streptomyces coelicolor, Mol Microbiol, vol.1384, issue.77, pp.943-957, 2010.

H. Tjalsma, G. Zanen, G. Venema, S. Bron, and J. Van-dijl, The potential active site of 1388 the lipoprotein-specific (type II) signal peptidase of Bacillus subtilis, J Biol Chem, vol.274, pp.1389-28191, 1999.

H. Tokuda, S. Matsuyama, and K. Tanaka-masuda, Structure, function and transport of 1392 lipoproteins in Escherichia coli. The Periplasm, pp.67-79, 2007.

H. Nakayama, Bacterial lipoproteins: biogenesis, virulence/pathogenicity and 1397 trafficking Bacterial membranes: structural and molecular biology, p.p.^pp, 2014.

M. Tokunaga, H. Tokunaga, and H. Wu, Post-translational modification and processing of Escherichia coli prolipoprotein in vitro., Proceedings of the National Academy of Sciences, vol.79, issue.7, pp.2255-1402, 1982.
DOI : 10.1073/pnas.79.7.2255

M. Tokunaga, J. Loranger, and H. Wu, Prolipoprotein modification and processing 1409 enzymes in Escherichia coli, J Biol Chem, vol.259, pp.3825-3830, 1984.

G. Tomlinson, S. Chimalapati, and T. Pollard, TLR-Mediated Inflammatory 1412 Responses to Streptococcus pneumoniae Are Highly Dependent on Surface Expression 1413 of Bacterial Lipoproteins, J Immunol, 2014.

W. Tschantz, M. Paetzel, G. Cao, D. Suciu, M. Inouye et al., Characterization of a soluble, catalytically active form of Escherichia coli leader peptidase: requirement of detergent or phospholipid for optimal activity, Biochemistry, vol.34, issue.12, pp.3935-3941, 1995.
DOI : 10.1021/bi00012a010

A. Tschumi, T. Grau, D. Albrecht, M. Rezwan, H. Antelmann et al., Functional Analyses of Mycobacterial Lipoprotein Diacylglyceryl Transferase and Comparative Secretome Analysis of a Mycobacterial lgt Mutant, Journal of Bacteriology, vol.194, issue.15, pp.3938-1422, 2012.
DOI : 10.1128/JB.00127-12

A. Typas, M. Banzhaf, and B. Van-den-berg-van-saparoea, Regulation of Peptidoglycan Synthesis by Outer-Membrane Proteins, Cell, vol.143, issue.7, pp.1097-1109, 2010.
DOI : 10.1016/j.cell.2010.11.038

S. Urban, Making the cut: central roles of intramembrane proteolysis in 1432 pathogenic microorganisms, Nature reviews, vol.7, pp.411-423, 2009.

D. Vidal-ingigliardi, S. Lewenza, and N. Buddelmeijer, Identification of Essential Residues in Apolipoprotein N-Acyl Transferase, a Member of the CN Hydrolase Family, Journal of Bacteriology, vol.189, issue.12, pp.4456-4464, 2007.
DOI : 10.1128/JB.00099-07

L. Villanueva, J. Damste, and S. Schouten, A re-evaluation of the archaeal membrane 1443 lipid biosynthetic pathway, Nature reviews, vol.12, pp.438-448, 2014.

P. Wang, E. Shim, B. Cravatt, R. Jacobsen, J. Schoeniger et al., Escherichia coli signal peptide peptidase A is a serine-lysine protease with a 1447 lysine recruited to the nonconserved amino-terminal domain in the S49 protease family, Biochemistry, vol.1446, issue.47, pp.6361-6369, 1448.

. Msba, Alternating access with a twist, Proceedings of the National Academy of Sciences of 1452 the United States of America, pp.19005-19010

C. Webb, J. Selkrig, A. Perry, N. Noinaj, S. Buchanan et al., Dynamic Association of BAM Complex Modules Includes Surface Exposure of the Lipoprotein BamC, Journal of Molecular Biology, vol.422, issue.4, pp.545-555, 1456.
DOI : 10.1016/j.jmb.2012.05.035

A. Dell and M. Smith, Glycosylation of the phosphate binding protein, PstS, in 1460 Streptomyces coelicolor by a pathway that resembles protein O-mannosylation in 1461 eukaryotes, Molecular microbiology, vol.71, pp.421-433, 2009.

D. White and F. Frerman, Fatty acid composition of the complex lipids of 1464 Staphylococcus aureus during the formation of the membrane-bound electron transport 1465 system, Journal of bacteriology, vol.95, pp.2198-2209, 1968.

W. Schreur, P. Rebel, J. Smits, M. Van-putten, J. Smith et al., Lgt Processing Is an Essential Step in Streptococcus suis Lipoprotein Mediated Innate Immune Activation, PLoS ONE, vol.274, issue.Pt 1, p.22299, 2011.
DOI : 10.1371/journal.pone.0022299.s003

P. Sander, T. Palmer, and M. Hutchings, Dissecting the complete lipoprotein 1473 biogenesis pathway in Streptomyces scabies, Mol Microbiol, vol.80, pp.1395-1412, 2011.

A. Williams and C. Raetz, Structural basis for the acyl chain selectivity and 1476 mechanism of UDP-N-acetylglucosamine acyltransferase, Proc Natl Acad Sci, vol.104, pp.1477-13543, 2007.

M. Williams, M. Fortson, C. Dykstra, P. Jensen, and S. Kushner, Identification and genetic mapping of the structural gene for an essential Escherichia coli membrane protein., Journal of Bacteriology, vol.171, issue.1, pp.565-568, 1989.
DOI : 10.1128/jb.171.1.565-568.1989

H. Wu, Biosynthesis of lipoproteins. Escherichia coli and Salmonella Cellular and 1484, 1996.

H. Wu, C. Hou, J. Lin, and D. Yem, Biochemical characterization of a mutant 1489 lipoprotein of Escherichia coli, Proceedings of the National Academy of Sciences of the 1490 United States of America, pp.1388-1392, 1977.

H. Wu, J. Lai, S. Hayashi, and C. Giam, Biogenesis of membrane lipoproteins in Escherichia coli, Biophysical Journal, vol.37, issue.1, pp.307-315, 1982.
DOI : 10.1016/S0006-3495(82)84679-1

H. Wu, M. Tokunaga, H. Tokunaga, S. Hayashi, and C. Giam, Posttranslational modification and processing of membrane lipoproteins in bacteria, Journal of Cellular Biochemistry, vol.31, issue.3, pp.161-171, 1983.
DOI : 10.1002/jcb.240220305

T. Wyckoff, S. Lin, R. Cotter, G. Dotson, and C. Raetz, Hydrocarbon Rulers in UDP-N-acetylglucosamine Acyltransferases, Journal of Biological Chemistry, vol.273, issue.49, pp.32369-32372, 1998.
DOI : 10.1074/jbc.273.49.32369

Y. Xiao and D. Wall, Genetic redundancy, proximity, and functionality of lspA, the 1503 target of antibiotic TA, in the Myxococcus xanthus producer strain, Journal, vol.196, pp.1174-1183, 1504.

Y. Xiao, K. Gerth, R. Müller, and D. Wall, Myxobacterium-produced antiobiotic TA 1507 (Myxovirescin) inhibits type II signal peptidase, Antimicrob Agents and Chemother, vol.56, pp.1508-2014, 2012.
DOI : 10.1128/aac.06148-11

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3318312

T. Yakushi, T. Tajima, S. Matsuyama, and H. Tokuda, Lethality of the covalent linkage between mislocalized major outer membrane lipoprotein and the peptidoglycan of Escherichia coli., Journal of Bacteriology, vol.179, issue.9, pp.2857-2862, 1997.
DOI : 10.1128/jb.179.9.2857-2862.1997

D. Yem and H. Wu, Genetic characterization of an Escherichia coli mutant altered 1518 in the structure of murein lipoprotein, Journal of bacteriology, vol.131, pp.759-764, 1977.

D. Yem and H. Wu, Physiological characterization of an Escherichia coli mutant 1521 altered in the structure of murein lipoprotein, Journal of bacteriology, vol.133, pp.1419-1426, 1978.