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In vitro combination of anidulafungin and voriconazole against intrinsically azole-susceptible and -resistant Aspergillus spp

Virginie Planche 1 Sebastien Ducroz 1 Alexandre Alanio 2 Marie-Elisabeth Bougnoux 3 Olivier Lortholary 2, 4 Eric Dannaoui 1
1 Unité de Parasitologie-Mycologie [CHU HEGP]
2 Mycologie moléculaire
3 Service de Microbiologie
4 Centre d'infectiologie Necker-Pasteur [CHU Necker]
Abstract : In vitro interaction of anidulafungin with voriconazole was tested by a microdilution broth checkerboard technique and an agar diffusion method against 30 Aspergillus clinical isolates belonging to five different species. By using a complete inhibition endpoint, indifferent interactions were observed for 97% of the isolates by the checkerboard technique (FIC index from 0.5 to 2) and for 100% of the isolates by the agar diffusion method (variation of -2 to +1 log(2) dilutions).
Keywords : Microbial Sensitivity Tests Pyrimidines Triazoles voriconazole Antifungal Agents Echinocandins Aspergillus Azoles Drug Combinations
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Submitted on : Tuesday, November 29, 2016 - 4:26:35 PM
Last modification on : Tuesday, December 1, 2020 - 11:36:08 AM

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Virginie Planche, Sebastien Ducroz, Alexandre Alanio, Marie-Elisabeth Bougnoux, Olivier Lortholary, et al.. In vitro combination of anidulafungin and voriconazole against intrinsically azole-susceptible and -resistant Aspergillus spp. Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2012, 56 (8), pp.4500--4503. ⟨10.1128/AAC.00045-12⟩. ⟨pasteur-01405248⟩

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