In vitro combination of anidulafungin and voriconazole against intrinsically azole-susceptible and -resistant Aspergillus spp

Virginie Planche (1) , Sebastien Ducroz (1) , Alexandre Alanio (2) , Marie-Elisabeth Bougnoux (3) , Olivier Lortholary (2, 4) , Eric Dannaoui (1)

1 Unité de Parasitologie-Mycologie [CHU HEGP]
2 Mycologie moléculaire
3 Service de Microbiologie
4 Centre d'infectiologie Necker-Pasteur [CHU Necker]

In vitro interaction of anidulafungin with voriconazole was tested by a microdilution broth checkerboard technique and an agar diffusion method against 30 Aspergillus clinical isolates belonging to five different species. By using a complete inhibition endpoint, indifferent interactions were observed for 97% of the isolates by the checkerboard technique (FIC index from 0.5 to 2) and for 100% of the isolates by the agar diffusion method (variation of -2 to +1 log(2) dilutions).

Keywords: Antifungal Agents; Aspergillus; Azoles; Drug Combinations; Echinocandins; Microbial Sensitivity Tests; Pyrimidines; Triazoles; voriconazole

Domains: Life Sciences [q-bio]; Mycology

Virginie Planche, Sebastien Ducroz, Alexandre Alanio, Marie-Elisabeth Bougnoux, Olivier Lortholary, et al.. In vitro combination of anidulafungin and voriconazole against intrinsically azole-susceptible and -resistant Aspergillus spp. Antimicrobial Agents and Chemotherapy, 2012, 56 (8), pp.4500--4503. ⟨10.1128/AAC.00045-12⟩. ⟨pasteur-01405248⟩