[NEW STRATEGIES FOR THE MICROBIOLOGICAL DIAGNOSIS OF VISCERAL MYCOSES]

Abstract : The recent improvements of the diagnosis of invasive mycoses have included the shortening of the species identification time for a rapid adaptation of the antifungal treatment, and the anticipation of the diagnosis thanks to biomarkers. Species identification is now achieved using MALDI-TOF 24 hours earlier than with the previous phenotypic tests. The aim is now to identify directly on positive blood bottle either using MALDI-TOF or molecular methods. The biomarkers are dominated by antigens (mannan, galactomanan, glucan) with available commercial kits. These antigens are mainly used as screening tests in patients at risk of invasive mycoses. Their main limitation is their weak specificity rather than their sensitivity. For circulating DNA, the quantitative real-time PCR format and the publication of recommendations for validation of diagnostic assays suggest they should be implemented soon in a diagnostic strategy.
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Article dans une revue
Revue du Praticien (La), J B Bailliere et Fils, 2015, 65 (10), pp.1325--1329
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https://hal-pasteur.archives-ouvertes.fr/pasteur-01405226
Contributeur : Floran Bidault <>
Soumis le : mardi 29 novembre 2016 - 16:14:33
Dernière modification le : jeudi 11 janvier 2018 - 06:21:36

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  • HAL Id : pasteur-01405226, version 1
  • PUBMED : 26979035

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Alexandre Alanio, Stéphane Bretagne. [NEW STRATEGIES FOR THE MICROBIOLOGICAL DIAGNOSIS OF VISCERAL MYCOSES]. Revue du Praticien (La), J B Bailliere et Fils, 2015, 65 (10), pp.1325--1329. 〈pasteur-01405226〉

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