Combined medico-surgical strategy for invasive sino-orbito-cerebral breakthrough fungal infection with Hormographiella aspergillata in an acute leukaemia patient
Abstract
Hormographiella aspergillata is a rare causative agent of invasive filamentous breakthrough infection, mostly arising after echinocandin exposure. We report a neutropenic patient who developed a severe sino-orbito-cerebral H. aspergillata infection while receiving empirical caspofungin, successfully controlled by an aggressive strategy associating surgical debridement and combined high-dose regimen of antifungal drugs.
Keywords
Molecular Sequence Data
basidiomycosis
Central Nervous System Fungal Infections
Combined Modality Therapy
Brain
Drug Resistance
Male
Fungal
Echinocandins
Antifungal Agents
Debridement
Agaricales
allogeneic haematopoietic stem cell transplantation
Acute
Leukemia
Fatal Outcome
Neutropenia
Myeloid
Hormographiella aspergillata
Humans
Young Adult
acute myeloid leukaemia
Origin : Publication funded by an institution
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