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Aspergillus spp. invasive external otitis: favourable outcome with a medical approach

Abstract : Aspergillus spp. invasive external otitis (IEO) is a rare infection. We performed a seven-year, single-centre retrospective study from 2007 to 2014 including all patients with proven Aspergillus spp. IEO. Twelve patients were identified. All patients had a poorly controlled diabetes mellitus and one underwent solid organ transplant. The most frequently isolated species was Aspergillus flavus (n = 10) and voriconazole was the first-line therapy in all cases, with a median length of treatment of 338.5 days (158-804 days). None of the patients underwent extensive surgery. The clinical outcome was excellent. However, otological sequelae were reported, including hearing impairment (n = 7) and facial palsy (n = 3).
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Submitted on : Tuesday, November 29, 2016 - 4:14:00 PM
Last modification on : Wednesday, August 19, 2020 - 11:18:13 AM

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E. Marchionni, P. Parize, A. Lefèvre, P. Vironneau, M. E. Bougnoux, et al.. Aspergillus spp. invasive external otitis: favourable outcome with a medical approach. Clinical Microbiology and Infection, Elsevier for the European Society of Clinical Microbiology and Infectious Diseases, 2016, 22 (5), pp.434--437. ⟨10.1016/j.cmi.2015.12.027⟩. ⟨pasteur-01405210⟩

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