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Aspergillus spp. invasive external otitis: favourable outcome with a medical approach

E. Marchionni 1, 2 P. Parize 1 A. Lefèvre 3 P. Vironneau 4 M. E. Bougnoux 5, 6 S. Poiree 3 H. Coignard-Biehler 1 S. E. Dewolf 1 K. Amazzough 1 F. Barchiesi 2 V. Jullien 7 Alexandre Alanio 8 D. Garcia-Hermoso 9 M. Wassef 10 R. Kania 4 O. Lortholary 11, 1, 9 F. Lanternier 1, 9, 11
1 Centre d'infectiologie Necker-Pasteur [CHU Necker]
2 UNIVPM - Università Politecnica delle Marche [Ancona]
3 Service de Radiologie et imagerie médicale [CHU Necker]
4 Service d'oto-rhino-laryngologie
5 Unité de Parasitologie-Mycologie, Service de Microbiologie [Hôpital Necker-Enfants-Malades, Paris]
6 Biologie et Pathogénicité fongiques
7 UPD5 - Université Paris Descartes - Paris 5
8 Laboratoire de Parasitologie-Mycologie [CHU Saint Louis, Paris]
9 CNRMA - Centre National de Référence des Mycoses invasives et antifongiques - Mycologie moléculaire
10 Hôpital Lariboisière, Department of Pathology, University of Paris 7 - Denis Diderot, Faculty of Medicine
11 Mycologie moléculaire
Abstract : Aspergillus spp. invasive external otitis (IEO) is a rare infection. We performed a seven-year, single-centre retrospective study from 2007 to 2014 including all patients with proven Aspergillus spp. IEO. Twelve patients were identified. All patients had a poorly controlled diabetes mellitus and one underwent solid organ transplant. The most frequently isolated species was Aspergillus flavus (n = 10) and voriconazole was the first-line therapy in all cases, with a median length of treatment of 338.5 days (158-804 days). None of the patients underwent extensive surgery. The clinical outcome was excellent. However, otological sequelae were reported, including hearing impairment (n = 7) and facial palsy (n = 3).
Keywords : voriconazole Invasive otitis Aspergillus spp. diabetes mellitus
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Journal articles
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Submitted on : Tuesday, November 29, 2016 - 4:14:00 PM
Last modification on : Wednesday, August 19, 2020 - 11:18:13 AM

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PASTEUR | CNRS | INRA | UNIV-PARIS5 | USPC | INRAE | UNIV-PARIS

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E. Marchionni, P. Parize, A. Lefèvre, P. Vironneau, M. E. Bougnoux, et al.. Aspergillus spp. invasive external otitis: favourable outcome with a medical approach. Clinical Microbiology and Infection, Elsevier for the European Society of Clinical Microbiology and Infectious Diseases, 2016, 22 (5), pp.434--437. ⟨10.1016/j.cmi.2015.12.027⟩. ⟨pasteur-01405210⟩

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