Department of Energy (grant no. DEFG0207ER64498 to V.deC.-L.) and by the National Institutes of Health (grant no. R01 GM70641-01 to V.deC.-L.) Fondation pour la Recherche Me´dicaleMe´dicale (FRM) to X.L. Funding for open access charge: CNRS. REFERENCES 1, Cell, vol.124, pp.1155-1168, 2006. ,
Yeast homolog of a cancer-testis antigen defines a new transcription complex, The EMBO Journal, vol.9, issue.15, pp.3576-3585, 2006. ,
DOI : 10.1126/science.1077790
URL : https://hal.archives-ouvertes.fr/hal-00133495
Qri7/OSGEPL, the mitochondrial version of the universal Kae1/YgjD protein, is essential for mitochondrial genome maintenance, Nucleic Acids Research, vol.37, issue.16, pp.5343-5352, 2009. ,
DOI : 10.1093/nar/gkp557
URL : https://hal.archives-ouvertes.fr/hal-00698096
[47] O-sialoglycoprotease from Pasteurella haemolytica, Methods Enzymol, vol.248, pp.728-740, 1995. ,
DOI : 10.1016/0076-6879(95)48049-8
Atomic Structure of the KEOPS Complex: An Ancient Protein Kinase-Containing Molecular Machine, Molecular Cell, vol.32, issue.2, pp.259-275, 2008. ,
DOI : 10.1016/j.molcel.2008.10.002
Structure of the archaeal Kae1/Bud32 fusion protein MJ1130: a model for the eukaryotic EKC/KEOPS subcomplex, The EMBO Journal, vol.57, issue.17, pp.2340-2351, 2008. ,
DOI : 10.1038/emboj.2008.157
URL : https://hal.archives-ouvertes.fr/hal-00357948
An archaeal orthologue of the universal protein Kae1 is an iron metalloprotein which exhibits atypical DNA-binding properties and apurinic-endonuclease activity in vitro, Nucleic Acids Research, vol.35, issue.18, pp.6042-6051, 2007. ,
DOI : 10.1093/nar/gkm554
URL : https://hal.archives-ouvertes.fr/hal-00195238
Structure???function analysis of yeast piD261/Bud32, an atypical protein kinase essential for normal cell life, Biochemical Journal, vol.364, issue.2, pp.457-463, 2002. ,
DOI : 10.1042/bj20011376
'Conserved hypothetical' proteins: prioritization of targets for experimental study, Nucleic Acids Research, vol.32, issue.18, pp.5452-5463, 2004. ,
DOI : 10.1093/nar/gkh885
Linking functionally related genes by sensitive and quantitative characterization of genetic interaction profiles, Proc. Natl Acad. Sci. USA, pp.5821-5826, 2008. ,
DOI : 10.1073/pnas.0710533105
URL : https://hal.archives-ouvertes.fr/pasteur-01404694
Adaptable gene-specific dye bias correction for two-channel DNA microarrays, Molecular Systems Biology, vol.112, p.266, 2009. ,
DOI : 10.1038/nbt836
URL : http://doi.org/10.1038/msb.2009.21
Linear Models and Empirical Bayes Methods for Assessing Differential Expression in Microarray Experiments, Statistical Applications in Genetics and Molecular Biology, vol.3, issue.1, p.3, 2004. ,
DOI : 10.2202/1544-6115.1027
The highly conserved eukaryotic DRG factors are required for efficient translation in a manner redundant with the putative RNA helicase Slh1, Nucleic Acids Research, vol.39, issue.6, 2010. ,
DOI : 10.1093/nar/gkq898
Fal1p is an essential DEAD-box protein involved in 40S-ribosomal-subunit biogenesis in Saccharomyces cerevisiae., Molecular and Cellular Biology, vol.17, issue.12, pp.7283-7294, 1997. ,
DOI : 10.1128/MCB.17.12.7283
The universal YrdC/Sua5 family is required for the formation of threonylcarbamoyladenosine in tRNA, Nucleic Acids Research, vol.37, issue.9, pp.2894-2909, 2009. ,
DOI : 10.1093/nar/gkp152
Molecular View of 43 S Complex Formation and Start Site Selection in Eukaryotic Translation Initiation, Journal of Biological Chemistry, vol.285, issue.28, pp.21203-21207, 2010. ,
DOI : 10.1074/jbc.R110.119743
The mechanism of eukaryotic translation initiation and principles of its regulation, Nature Reviews Molecular Cell Biology, vol.4, issue.2, pp.113-127, 2010. ,
DOI : 10.1038/nrm2838
A Consensus of Core Protein Complex Compositions for Saccharomyces cerevisiae, Molecular Cell, vol.38, issue.6, pp.916-928, 2010. ,
DOI : 10.1016/j.molcel.2010.06.002
AND THE GENERAL AMINO ACID CONTROL OF YEAST, Annual Review of Microbiology, vol.59, issue.1, pp.407-450, 2005. ,
DOI : 10.1146/annurev.micro.59.031805.133833
An improved map of conserved regulatory sites for Saccharomyces cerevisiae, BMC Bioinformatics, vol.7, issue.1, p.113, 2006. ,
DOI : 10.1186/1471-2105-7-113
A segment of GCN4 mRNA containing the upstream AUG codons confers translational control upon a heterologous yeast transcript., Proc. Natl Acad. Sci. USA, pp.2863-2867, 1987. ,
DOI : 10.1073/pnas.84.9.2863
Genetic identification of yeast 18S rRNA residues required for efficient recruitment of initiator tRNA(Met) and AUG selection, 2008. ,
Eukaryotic Translation Initiation Factor 5 Is Critical for Integrity of the Scanning Preinitiation Complex and Accurate Control of GCN4 Translation, Molecular and Cellular Biology, vol.25, issue.13, pp.5480-5491, 2005. ,
DOI : 10.1128/MCB.25.13.5480-5491.2005
Isolation and functional characterization of a temperature-sensitive mutant of the yeast Saccharomyces cerevisiae in translation initiation factor eIF5: an eIF5-dependent cell-free translation system, Gene, vol.244, issue.1-2, pp.109-118, 2000. ,
DOI : 10.1016/S0378-1119(99)00570-3
Characterization of Translation Initiation Factor 5 (eIF5) fromSaccharomyces cerevisiae: FUNCTIONAL HOMOLOGY WITH MAMMALIAN eIF5 AND THE EFFECT OF DEPLETION OF eIF5 ON PROTEIN SYNTHESIS IN VIVO ANDIN VITRO, Journal of Biological Chemistry, vol.272, issue.29, pp.18333-18340, 1997. ,
DOI : 10.1074/jbc.272.29.18333
The Sua5 Protein Is Essential for Normal Translational Regulation in Yeast, Molecular and Cellular Biology, vol.30, issue.1, pp.354-363, 2010. ,
DOI : 10.1128/MCB.00754-09
Isolation and characterization of SUA5, a novel gene required for normal growth in Saccharomyces cerevisiae, Genetics, vol.131, pp.791-801, 1992. ,
A role for the universal Kae1/Qri7/YgjD (COG0533) family in tRNA modification, The EMBO Journal, vol.70, issue.5, pp.882-893, 2011. ,
DOI : 10.1038/emboj.2010.363
URL : https://hal.archives-ouvertes.fr/hal-00593551
The highly conserved KEOPS/EKC complex is essential for a universal tRNA modification, t6A, The EMBO Journal, vol.209, issue.5, pp.873-881, 2011. ,
DOI : 10.1038/emboj.2010.343
into modified nucleoside of transfer ribonucleic acid, Biochemical Journal, vol.127, issue.3, pp.515-519, 1972. ,
DOI : 10.1042/bj1270515
Biosynthesis and specific labeling of N-(purin-6-ylcarbamoyl)threonine of Escherichiacoli transfer RNA, Biochemical and Biophysical Research Communications, vol.46, issue.2, pp.831-838, 1972. ,
DOI : 10.1016/S0006-291X(72)80216-X
Molecular Recognition of the Identity-determinant Set of Isoleucine Transfer RNA from Escherichia coli, Journal of Molecular Biology, vol.236, issue.3, pp.710-724, 1994. ,
DOI : 10.1006/jmbi.1994.1184
GCD2, a translational repressor of the GCN4 gene, has a general function in the initiation of protein synthesis in Saccharomyces cerevisiae., Molecular and Cellular Biology, vol.11, issue.6, pp.3203-3216, 1991. ,
DOI : 10.1128/MCB.11.6.3203
Naturally-occurring Modification Restricts the Anticodon Domain Conformational Space of tRNAPhe, Journal of Molecular Biology, vol.334, issue.5, pp.901-918, 2003. ,
DOI : 10.1016/j.jmb.2003.09.058
Effect of Threonylcarbamoyl Modification (t6A) in Yeast tRNAArgIII on Codon-Anticodon and Anticodon-Anticodon Interactions. A Thermodynamic and Kinetic Evaluation, European Journal of Biochemistry, vol.28, issue.1, pp.207-213, 1981. ,
DOI : 10.1016/0022-2836(73)90021-1
Defects in tRNA Processing and Nuclear Export Induce GCN4 Translation Independently of Phosphorylation of the alpha Subunit of Eukaryotic Translation Initiation Factor 2, Molecular and Cellular Biology, vol.20, issue.7, pp.2505-2516, 2000. ,
DOI : 10.1128/MCB.20.7.2505-2516.2000
Multicopy tRNA genes functionally suppress mutations in yeast eIF-2 alpha kinase GCN2: evidence for separate pathways coupling GCN4 expression to unchanged tRNA., Molecular and Cellular Biology, vol.14, issue.12, pp.7920-7932, 1994. ,
DOI : 10.1128/MCB.14.12.7920
Enzymic synthesis of N-(purin-6-ylcarbamoyl)threonine, an anticodon-adjacent base in transfer ribonucleic acid, Biochemistry, vol.13, issue.22, pp.4622-4628, 1974. ,
DOI : 10.1021/bi00719a024
GTP hydrolysis controls stringent selection of the AUG start codon during translation initiation in Saccharomyces??cerevisiae, Genes & Development, vol.11, issue.18, pp.2396-2413, 1997. ,
DOI : 10.1101/gad.11.18.2396
Multiple roles for the C-terminal domain of eIF5 in translation initiation complex assembly and GTPase activation, The EMBO Journal, vol.20, issue.9, pp.2326-2337, 2001. ,
DOI : 10.1093/emboj/20.9.2326
Programmed translational frameshifting in a gene required for yeast telomere replication, Current Biology, vol.7, issue.12, pp.969-976, 1997. ,
DOI : 10.1016/S0960-9822(06)00416-7
Sua5p a single-stranded telomeric DNA-binding protein facilitates telomere replication, The EMBO Journal, vol.143, issue.10, pp.1466-1478, 2009. ,
DOI : 10.1126/science.289.5480.771