Absolute requirement for the pre-T cell receptor α chain during NK1.1+ TCRα β cell development

Abstract : Most natural killer T (NKT) cells express a highly skewed alphabeta TCR repertoire, consisting of an invariant V alpha14-J alpha281 chain paired preferentially with a polyclonal Vbeta8.2 chain. This repertoire is positively selected by the monomorphic CD1d molecule expressed on cells of hematopoietic origin. The origin of NKT cells and their lineage relationship to conventional T cells is controversial. We show here that the development of NKT cells is absolutely dependent on expression of the pre-TCRalpha chain, in marked contrast to conventional T cells which arise in significant numbers even in the absence of a functional pre-TCR. Distinct developmental requirements for pre-TCR expression in the NKT and T cell lineages may reflect differences in the ability of the TCRalphabeta to substitute functionally for the pre-TCR in immature precursor cells.
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Article dans une revue
European Journal of Immunology, Wiley-VCH Verlag, 1999, 29 (6), pp.1966 - 1971
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https://hal-pasteur.archives-ouvertes.fr/pasteur-01402835
Contributeur : Bérengère Hugot <>
Soumis le : vendredi 25 novembre 2016 - 11:27:30
Dernière modification le : mercredi 7 décembre 2016 - 11:41:39

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  • HAL Id : pasteur-01402835, version 1
  • PUBMED : 10382759

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Gérard Eberl, Hans Jörg Fehling, Harald Von Boehmer, H. Robson Macdonald. Absolute requirement for the pre-T cell receptor α chain during NK1.1+ TCRα β cell development. European Journal of Immunology, Wiley-VCH Verlag, 1999, 29 (6), pp.1966 - 1971. 〈pasteur-01402835〉

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