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Journal articles
An essential function for the nuclear receptor RORγt in the generation of fetal lymphoid tissue inducer cells
Abstract : Lymphoid tissue inducer (LTi) cells are associated with early development of lymph nodes and Peyer's patches. We show here that during fetal life the nuclear hormone receptor RORgamma(t) is expressed exclusively in and is required for the generation of LTi cells. RORgamma(t+) LTi cells provide essential factors, among which lymphotoxin-alpha1beta2 is necessary but not sufficient for activation of the mesenchyma in lymph node and Peyer's patch anlagen. This early LTi cell-mediated activation of lymph node and Peyer's patch mesenchyma forms the necessary platform for the subsequent development of mature lymphoid tissues.
Comment in
Lymphoid organogenesis: getting the green light from RORgamma(t).
Cited literature [43 references]
https://hal-pasteur.archives-ouvertes.fr/pasteur-01402773
Contributor : Bérengère Hugot <>
Submitted on : Friday, November 25, 2016 - 10:35:50 AM
Last modification on : Wednesday, August 14, 2019 - 11:00:03 AM
Long-term archiving on: : Tuesday, March 21, 2017 - 8:08:14 AM
Contributor : Bérengère Hugot <>
Submitted on : Friday, November 25, 2016 - 10:35:50 AM
Last modification on : Wednesday, August 14, 2019 - 11:00:03 AM
Long-term archiving on: : Tuesday, March 21, 2017 - 8:08:14 AM
File
ni1022.pdf
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