Microbiota-induced tertiary lymphoid tissues aggravate inflammatory disease in the absence of RORγt and LTi cells - Archive ouverte HAL Access content directly
Journal Articles Journal of Experimental Medicine Year : 2011

Microbiota-induced tertiary lymphoid tissues aggravate inflammatory disease in the absence of RORγt and LTi cells

(1, 2) , (1) , (1) , (3) , (4) , (1) , (1)
1
2
3
4

Abstract

The programmed development of lymph nodes and Peyer's patches during ontogeny requires lymphoid tissue inducer (LTi) cells that express the nuclear hormone receptor RORγt. After birth, LTi cells in the intestine cluster into cryptopatches, the precursors of isolated lymphoid follicles (ILFs), which are induced to form by symbiotic bacteria and maintain intestinal homeostasis. We show that in RORγt-deficient mice, which lack LTi cells, programmed lymphoid tissues, ILFs, and Th17 cells, bacterial containment requires the generation of large numbers of tertiary lymphoid tissues (tLTs) through the activity of B cells. However, upon epithelial damage, these mice develop severe intestinal inflammation characterized by extensive recruitment of neutrophils and IgG(+) B cells, high expression of activation-induced deaminase in tLTs, and wasting disease. The pathology was prevented by antibiotic treatment or inhibition of lymphoid tissue formation and was significantly decreased by treatment with intravenous immunoglobulin G (IVIG). Our data show that intestinal immunodeficiency, such as an absence in RORγt-mediated proinflammatory immunity, can be compensated by increased lymphoid tissue genesis. However, this comes at a high cost for the host and can lead to a deregulated B cell response and aggravated inflammatory pathology.
Fichier principal
Vignette du fichier
125full.pdf (2.1 Mo) Télécharger le fichier
Origin : Publisher files allowed on an open archive
Loading...

Dates and versions

pasteur-01402751 , version 1 (25-11-2016)

Identifiers

Cite

Matthias Lochner, Caspar Ohnmacht, Laura Presley, Pierre Bruhns, Mustapha Si-Tahar, et al.. Microbiota-induced tertiary lymphoid tissues aggravate inflammatory disease in the absence of RORγt and LTi cells. Journal of Experimental Medicine, 2011, 208 (1), pp.125 - 134. ⟨10.1084/jem.20100052⟩. ⟨pasteur-01402751⟩
252 View
216 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More