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The development of LTi cells

Marie Cherrier 1 Gérard Eberl 1, * 
Abstract : Lymphoid tissue inducer (LTi) cells are programmed by the mammalian fetus to induce the development of lymph nodes and Peyer's patches. LTi cells share a pro-inflammatory profile with Th17 cells, as well as their requirement for the transcription factor RORγt. We discuss here the latest data on the fetal and post-natal development of LTi cells, and their relationship with the larger family of innate lymphoid cells (ILCs). We suggest that the re-programming of RORγt in a subset of common lymphoid progenitors allowed mammals to develop lymphoid organs before birth, whereas other vertebrates only develop such organs in response to infection or injury.
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Submitted on : Friday, November 25, 2016 - 10:03:39 AM
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Marie Cherrier, Gérard Eberl. The development of LTi cells. Current Opinion in Immunology, 2012, 24 (2), pp.178 - 183. ⟨10.1016/j.coi.2012.02.003⟩. ⟨pasteur-01402733⟩



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