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The development of LTi cells

Abstract : Lymphoid tissue inducer (LTi) cells are programmed by the mammalian fetus to induce the development of lymph nodes and Peyer's patches. LTi cells share a pro-inflammatory profile with Th17 cells, as well as their requirement for the transcription factor RORγt. We discuss here the latest data on the fetal and post-natal development of LTi cells, and their relationship with the larger family of innate lymphoid cells (ILCs). We suggest that the re-programming of RORγt in a subset of common lymphoid progenitors allowed mammals to develop lymphoid organs before birth, whereas other vertebrates only develop such organs in response to infection or injury.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-01402733
Contributor : Bérengère Hugot <>
Submitted on : Friday, November 25, 2016 - 10:03:39 AM
Last modification on : Monday, January 13, 2020 - 5:08:07 PM

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Marie Cherrier, Gérard Eberl. The development of LTi cells. Current Opinion in Immunology, Elsevier, 2012, 24 (2), pp.178 - 183. ⟨10.1016/j.coi.2012.02.003⟩. ⟨pasteur-01402733⟩

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