Notch, Id2, and RORγt sequentially orchestrate the fetal development of lymphoid tissue inducer cells - Institut Pasteur Accéder directement au contenu
Article Dans Une Revue Journal of Experimental Medicine Année : 2012

Notch, Id2, and RORγt sequentially orchestrate the fetal development of lymphoid tissue inducer cells

Résumé

Lymphoid tissue development is initiated during embryogenesis by the migration of lymphoid tissue inducer (LTi) cells from the fetal liver to the periphery, where they induce the formation of lymph nodes and Peyer's patches. In the fetal liver, a subset of common lymphoid progenitors (CLPs) that expresses the integrin α4β7 gives rise to LTi cells, a process strictly dependent on the expression of the transcriptional repressor Id2 and the nuclear hormone receptor retinoic acid-related orphan receptor γ t (RORγt). In this study, we show that Id2 and RORγt are sequentially up-regulated during LTi cell development, matching two waves of differentiation with opposite requirements for Notch signaling. Both the expression of Id2 and Notch are required for the generation of α4β7(+) RORγt(-) fetal progenitors, but Notch subsequently blocks progression to the RORγt(+) stage and final maturation of LTi cells. Notch is therefore a necessary switch to engage the LTi developmental pathway, but needs to be turned off later to avoid diversion to the T cell fate.

Domaines

Immunologie
Fichier principal
Vignette du fichier
729full.pdf (3.04 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte
Loading...

Dates et versions

pasteur-01402729 , version 1 (25-11-2016)

Identifiants

Citer

Marie Cherrier, Shinichiro Sawa, Gérard Eberl. Notch, Id2, and RORγt sequentially orchestrate the fetal development of lymphoid tissue inducer cells. Journal of Experimental Medicine, 2012, 209 (4), pp.729 - 740. ⟨10.1084/jem.20111594⟩. ⟨pasteur-01402729⟩
36 Consultations
162 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More