Development and regulation of RORγt + innate lymphoid cells

Sascha Cording (1) , Jasna Medvedovic (1) , Marie Cherrier (2, 1) , Gérard Eberl (1)

1 Développement des Tissus Lymphoïdes
2 INEM - UM 111 (UMR 8253 / U1151) - Institut Necker Enfants-Malades

RORγt(+) innate lymphoid cells (ILCs), or ILC3, play a fundamental role in the development of lymphoid tissues, as well as in homeostasis and defence of mucosal tissues. These cells produce IL-22, IL-17A and LTα1β2, key cytokines for the activation of epithelial defences and the recruitment of polymorphonuclear phagocytes. In the absence of ILC3, the early defence to infection and resistance to injury are compromised. Given the importance of ILC3 in mucosal immunity, significant efforts are made to discover their multiple functions and decipher their mode of action and regulation.

Keywords: IL-22; Innate lymphoid cells; Mucosal immunity; RORγt

Domains: Immunology; Innate immunity

Sascha Cording, Jasna Medvedovic, Marie Cherrier, Gérard Eberl. Development and regulation of RORγt + innate lymphoid cells. FEBS Letters, 2014, 588 (22), pp.4176 - 4181. ⟨10.1016/j.febslet.2014.03.034⟩. ⟨pasteur-01402717⟩