The biology of bacterial peptidoglycans and their impact on host immunity and physiology - Archive ouverte HAL Access content directly
Journal Articles Cellular Microbiology Year : 2014

The biology of bacterial peptidoglycans and their impact on host immunity and physiology

(1, 2) , (3) , (3) , (1, 2)
1
2
3

Abstract

Peptidoglycans (PGN) are a constituent of the bacterial cell wall, and are shed as bacteria divide. The presence of PGN is therefore a marker of bacterial activity that has been exploited by both plants and animals to induce defence mechanisms. Pattern recognition receptors that recognize PGN are extremely well conserved throughout evolution and shown to play important and diverse role in the development, homeostasis and activation of the immune system. In addition, PGN can be detected beyond mucosal surfaces, and their receptor can be expressed in tissues and cells that are far from the niches where bacteria reside. Thus, PGN affects not only the host's immunity, but also more generally the host's physiology. In this review, we discuss the biochemistry and biology of PGN, and their intriguing effects on the development of the immune system and the host physiology.
Not file

Dates and versions

pasteur-01402716 , version 1 (25-11-2016)

Identifiers

Cite

Richard Wheeler, Grégoire Chevalier, Gérard Eberl, Ivo Gomperts Boneca. The biology of bacterial peptidoglycans and their impact on host immunity and physiology. Cellular Microbiology, 2014, 16 (7), pp.1014 - 1023. ⟨10.1111/cmi.12304⟩. ⟨pasteur-01402716⟩
46 View
0 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More