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Journal articles
Circulating Plasmacytoid Dendritic Cells in Acutely Infected Patients with Hepatitis C Virus Genotype 4 Are Normal in Number and Phenotype
Hala Mansour
1
Melissa e. Laird
2
Rasha Saleh
3
Armanda Casrouge
2
Noha sharaf Eldin
3
Sherif el Kafrawy
1
Maha Hamdy
3
Jérémie Decalf
2
Brad r. Rosenberg
4
Arnaud Fontanet
5
Mohammed Abdel‐hamid
1, 6
Mostafa k. Mohamed
1, 2
Matthew l. Albert
2
Mona Rafik
3
Brad r. Rosenberg 4
Author
Arnaud Fontanet 5
Author
Mohammed Abdel‐hamid 1, 6
Author
Mostafa k. Mohamed 1, 2
Author
Matthew l. Albert 2
Author
Mona Rafik 3
Author
1
liver diseases research unit [Le Caire] (Egypt)
- National Hepatology and Tropical Medicine Research Institute (Le Caire - Egypt)
2
Immunobiologie des Cellules Dendritiques (25-28 rue du Docteur Roux, F-75724 Paris Cedex 15 - France)
- Institut Pasteur [Paris] (25-28, rue du docteur Roux, 75724 Paris cedex 15 - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U818 (101, rue de Tolbiac, 75013 Paris - France)
3
Faculty of medicine [Le Caire] (Egypt)
- Université Ain Shams (Khalifa El-Maamon St، El-Qobba Bridge, Cairo - Egypt)
4
Weill Cornell/Rockefeller/Sloan-Kettering Tri-Institutional MD/PhD Program (New-york - United States)
- Rockefeller University [New York] (1230 York Ave, New York, NY 10065, États-Unis - United States)
- Weill Medical College of Cornell University [New York] (Manhattan - United States)
5
Epidémiologie des Maladies Emergentes - Emerging Diseases Epidemiology (Département Infection et Epidémiologie, 25-28 rue du Docteur Roux, F-75724 Paris Cedex 15 - France)
- PACRI - Pasteur-Cnam risques infectieux et émergents (Paris - France)
- CNAM - Conservatoire National des Arts et Métiers [CNAM] (France)
- Institut Pasteur [Paris] (25-28, rue du docteur Roux, 75724 Paris cedex 15 - France)
Abstract : The incidence of hepatitis C virus (HCV) genotype 4 infection in Egypt provides a unique opportunity to study the innate immune response to symptomatic acute HCV infection. We investigated whether plasmacytoid dendritic cells (pDCs) are activated as a result of HCV infection. We demonstrate that, even during symptomatic acute infection, circulating pDCs maintained a similar precursor frequency and resting phenotype, compared with pDCs in healthy individuals. Moreover, stimulation with a Toll-like receptor 9 agonist resulted in an intact inflammatory response. These data support the growing consensus that pDCs are not directly activated by HCV and therefore are viable targets for immunotherapy throughout HCV infection.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-01402091
Contributor : Marie-Christine Vougny <>
Submitted on : Thursday, November 24, 2016 - 11:18:47 AM
Last modification on : Monday, April 20, 2020 - 2:46:02 PM
Contributor : Marie-Christine Vougny <>
Submitted on : Thursday, November 24, 2016 - 11:18:47 AM
Last modification on : Monday, April 20, 2020 - 2:46:02 PM
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- HAL Id : pasteur-01402091, version 1
- PUBMED : 20958210
- DOI : 10.1086/656777
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PASTEUR | CNAM | ATP-IMMUN | UNIV-HESAM
Citation
Hala Mansour, Melissa e. Laird, Rasha Saleh, Armanda Casrouge, Noha sharaf Eldin, et al.. Circulating Plasmacytoid Dendritic Cells in Acutely Infected Patients with Hepatitis C Virus Genotype 4 Are Normal in Number and Phenotype. Journal of Infectious Diseases, Oxford University Press (OUP), 2010, 202 (11), pp.1671 - 1675. ⟨10.1086/656777⟩. ⟨pasteur-01402091⟩
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