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Genome Mining Expands the Chemical Diversity of the Cyanobactin Family to Include Highly Modified Linear Peptides

Abstract : Ribosomal peptides are produced through the posttranslational modification of short precursor peptides. Cyanobactins are a growing family of cyclic ribosomal peptides produced by cyanobacteria. However, a broad systematic survey of the genetic capacity to produce cyanobactins is lacking. Here we report the identification of 31 cyanobactin gene clusters from 126 genomes of cyanobacteria. Genome mining suggested a complex evolutionary history defined by horizontal gene transfer and rapid diversification of precursor genes. Extensive chemical analyses demonstrated that some cyanobacteria produce short linear cyanobactins with a chain length ranging from three to five amino acids. The linear peptides were N-prenylated and O-methylated on the N and C termini, respectively, and named aeruginosamide and viridisamide. These findings broaden the structural diversity of the cyanobactin family to include highly modified linear peptides with rare posttranslational modifications.
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Submitted on : Wednesday, October 26, 2016 - 4:34:58 PM
Last modification on : Wednesday, June 17, 2020 - 3:42:03 PM

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Niina Leikoski, Liwei Liu, Jouni Jokela, Matti Wahlsten, Muriel Gugger, et al.. Genome Mining Expands the Chemical Diversity of the Cyanobactin Family to Include Highly Modified Linear Peptides. Chemistry and Biology, Elsevier, 2013, 20 (8), pp.1033 - 1043. ⟨10.1016/j.chembiol.2013.06.015⟩. ⟨pasteur-01388247⟩

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