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Journal articles
Genome Mining Expands the Chemical Diversity of the Cyanobactin Family to Include Highly Modified Linear Peptides
Abstract : Ribosomal peptides are produced through the posttranslational modification of short precursor peptides. Cyanobactins are a growing family of cyclic ribosomal peptides produced by cyanobacteria. However, a broad systematic survey of the genetic capacity to produce cyanobactins is lacking. Here we report the identification of 31 cyanobactin gene clusters from 126 genomes of cyanobacteria. Genome mining suggested a complex evolutionary history defined by horizontal gene transfer and rapid diversification of precursor genes. Extensive chemical analyses demonstrated that some cyanobacteria produce short linear cyanobactins with a chain length ranging from three to five amino acids. The linear peptides were N-prenylated and O-methylated on the N and C termini, respectively, and named aeruginosamide and viridisamide. These findings broaden the structural diversity of the cyanobactin family to include highly modified linear peptides with rare posttranslational modifications.
Cited literature [37 references]
https://hal-pasteur.archives-ouvertes.fr/pasteur-01388247
Contributor : Bénédicte Benedic <>
Submitted on : Wednesday, October 26, 2016 - 4:34:58 PM
Last modification on : Wednesday, June 17, 2020 - 3:42:03 PM
Contributor : Bénédicte Benedic <>
Submitted on : Wednesday, October 26, 2016 - 4:34:58 PM
Last modification on : Wednesday, June 17, 2020 - 3:42:03 PM
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