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Pathogenesis of skin ulcers: lessons from the Mycobacterium ulcerans and Leishmania spp. pathogens

Abstract : Skin ulcers are most commonly due to circulatory or metabolic disorders and are a major public health concern. In developed countries, chronic wounds affect more than 1% of the population and their incidence is expected to follow those observed for diabetes and obesity. In tropical and subtropical countries, an additional issue is the occurrence of ulcers of infectious origins with diverse aetiologies. While the severity of cutaneous Leishmaniasis correlates with protective immune responses, Buruli ulcers caused by Mycobacterium ulcerans develop in the absence of inflammation. Based on these two examples, this review aims to demonstrate how studies on microorganism-provoked wounds can provide insight into the molecular mechanisms controlling skin integrity. We highlight the potential interest of a mouse model of non-inflammatory skin ulceration caused by intradermal injection of mycolactone, an unusual lipid toxin with ulcerative and immunosuppressive properties produced by M. ulcerans.
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2014 – PMID 24445815.pdf
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Laure Guenin-Macé, Reid Oldenburg, Fabrice Chrétien, Caroline Demangel. Pathogenesis of skin ulcers: lessons from the Mycobacterium ulcerans and Leishmania spp. pathogens. Cellular and Molecular Life Sciences, Springer Verlag, 2014, 71 (13), pp.2443 - 2450. ⟨10.1007/s00018-014-1561-z⟩. ⟨pasteur-01387237⟩

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