Skip to Main content Skip to Navigation
Journal articles

The impact of macroautophagy on CD8 + T-cell-mediated antiviral immunity

Abstract : Macroautophagy is a catabolic recycling pathway, which can be induced by various stress stimuli. Viruses are able to manipulate autophagy in the cells that they infect. The impact of autophagy on the innate immune response to viruses and its stimulatory role in antigen presentation to CD4(+) T cells are well documented. Herein, we present the impact of autophagy on the activation of cytotoxic T lymphocyte (CTL)-mediated antiviral immune responses, which are required for the eradication or control of multiple viruses. We first discuss the general mechanisms by which viruses can either induce or block autophagy in cells. We then explore the cross-talk between autophagy and innate immune processes, which are both first line defenses against viruses; and constitute crucial steps for the initiation of potent adaptive immune responses. We describe the impact of autophagy on the presentation of viral peptide antigens on class I major histocompatibility complex (MHC I), a prerequisite for the priming of CTL responses. In sum, our review highlights the interplay between viruses and three integrated host response pathways - autophagy, innate and adaptive immunity - providing a framework for future mechanistic and pathogenesis-based research.
Document type :
Journal articles
Complete list of metadatas

https://hal-pasteur.archives-ouvertes.fr/pasteur-01385514
Contributor : Marie-Christine Vougny <>
Submitted on : Friday, October 21, 2016 - 2:51:45 PM
Last modification on : Thursday, April 2, 2020 - 3:18:03 PM

Links full text

Identifiers

Collections

Citation

Brieuc P. Perot, Molly A Ingersoll, Matthew L. Albert. The impact of macroautophagy on CD8 + T-cell-mediated antiviral immunity. Immunological Reviews, Wiley, 2013, Special Issue: Immunity to Viruses 255 (1), pp.40 - 56. ⟨10.1111/imr.12096⟩. ⟨pasteur-01385514⟩

Share

Metrics

Record views

135