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Sugar-Modified Foldamers as Conformationally Defined and Biologically Distinct Glycopeptide Mimics

Aloysius Siriwardena 1, * Kiran Kumar Pulukuri 2 Pancham S. Kandiyal 2 Saumya Roy 1 Omprakash Bande 1 Subhash Ghosh 3 José Manuel Garcia fernández 4 Fernando Ariel martin 5 Jean-Marc Ghigo 5 Christophe Beloin 5 Keigo Ito 6 Robert J. Woods 7, 6 Ravi Sankar Ampapathi 2, * Tushar Kanti Chakraborty 2, *
* Corresponding author
1 LG - Laboratoire des Glucides
2 CSIR-CDRI - CSIR-Central Drug Research Institute
3 IICT - CSIR Indian Institute of Chemical Technology
4 Universidad de Sevilla
5 Génétique des Biofilms
6 University of Georgia [USA]
7 NUI Galway - National University of Ireland [Galway]
Abstract : To fold or not to fold? It is shown that attached sugars play a defining role in the conformations adopted by a pair of novel SAA-derived foldamers in water and that these differences are reflected in the contrasting interactions of these glycofoldamers with various biological targets. C green, O red, N blue, H gray; yellow oval=mannose.
Keywords : restrained molecular dynamics solution conformational preferences protein–carbohydrate interactions neoglycopeptides glycofoldamers
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https://hal-pasteur.archives-ouvertes.fr/pasteur-01385432
Contributor : Anne Lassailly-Bondaz <>
Submitted on : Friday, October 21, 2016 - 12:58:24 PM
Last modification on : Friday, April 3, 2020 - 12:32:02 PM

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Aloysius Siriwardena, Kiran Kumar Pulukuri, Pancham S. Kandiyal, Saumya Roy, Omprakash Bande, et al.. Sugar-Modified Foldamers as Conformationally Defined and Biologically Distinct Glycopeptide Mimics. Angewandte Chemie International Edition, Wiley-VCH Verlag, 2013, 52 (39), pp.10221 - 10226. ⟨10.1002/anie.201304239⟩. ⟨pasteur-01385432⟩

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