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The Pil3 pilus of Streptococcus gallolyticus binds to intestinal mucins and to fibrinogen

Abstract : Streptococcus gallolyticus is a commensal bacterium responsible for infectious endocarditis in the elderly, which has frequently been associated with colonic carcinoma. Whether this species is a cause or a consequence of colorectal cancer remains unknown. We recently demonstrated that S. gallolyticus Pil3 pilus is required for adhesion to colonic mucus and for colonization of mouse distal colon. We show here that Pil3 pilus binds equally well to human colonic mucins derived from HT29-MTX cells and to human stomach mucins from healthy donors. In addition, we have found that Pil3 also binds to human fibrinogen, which expands the repertoire of Pil3 host ligands.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-01385177
Contributor : Patrick Trieu-Cuot <>
Submitted on : Thursday, October 20, 2016 - 10:56:00 PM
Last modification on : Tuesday, June 16, 2020 - 2:22:01 PM

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Mariana Martins, Constance Porrini, Laurence Du Merle, Camille Danne, Catherine Robbe-Masselot, et al.. The Pil3 pilus of Streptococcus gallolyticus binds to intestinal mucins and to fibrinogen. Gut microbes, Taylor & Francis, 2016, 7 (6), pp.526-532. ⟨10.1080/19490976.2016.1239677⟩. ⟨pasteur-01385177⟩

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