An environmental bacterial taxon with a large and distinct metabolic repertoire, Nature, vol.458, issue.7486, pp.58-62, 2014. ,
DOI : 10.1101/gr.1239303
Two classes of metabolites fromTheonella swinhoei are localized in distinct populations of bacterial symbionts, Experientia, vol.266, issue.7, pp.716-722, 1996. ,
DOI : 10.1007/BF01925581
Identification of the antifungal peptide-containing symbiont of the marine sponge Theonella swinhoei as a novel ??-proteobacterium, " Candidatus Entotheonella palauensis", Marine Biology, vol.136, issue.6, pp.969-977, 2000. ,
DOI : 10.1007/s002270000273
The Biosynthetic Logic of Polyketide Diversity, Angewandte Chemie International Edition, vol.45, issue.26, pp.4688-4716, 2009. ,
DOI : 10.1002/anie.200806121
Biosynthesis of polyketides by trans-AT polyketide synthases, Natural Product Reports, vol.23, issue.7, pp.996-1047, 2010. ,
DOI : 10.1039/b816430b
Exploiting the mosaic structure of trans-acyltransferase polyketide synthases for natural product discovery and pathway dissection, Nature Biotechnology, vol.68, issue.2, pp.225-233, 2008. ,
DOI : 10.1038/nbt1379
A polyketide synthase-peptide synthetase gene cluster from an uncultured bacterial symbiont of Paederus beetles, Proc. Natl. Acad. Sci. USA 99, pp.14002-14007, 2002. ,
DOI : 10.1073/pnas.222481399
Pathogenic fungus harbours endosymbiotic bacteria for toxin production, Nature, vol.437, issue.7060, pp.884-888, 2005. ,
DOI : 10.1038/nature03997
Polyketide assembly lines of uncultivated sponge symbionts from structure-based gene targeting, Nature Chemical Biology, vol.103, issue.7, pp.494-501, 2009. ,
DOI : 10.1038/nchembio.176
Complex microbiome underlying secondary and primary metabolism in the tunicate-Prochloron symbiosis, Proc. Natl. Acad. Sci. USA, pp.1423-1432, 2011. ,
DOI : 10.1073/pnas.1111712108
URL : https://hal.archives-ouvertes.fr/hal-01218508
Rapid isolation of rare clones from highly complex DNA libraries by PCR analysis of liquid gel pools, Journal of Microbiological Methods, vol.68, issue.2, pp.434-436, 2007. ,
DOI : 10.1016/j.mimet.2006.09.009
Something from (almost) nothing: the impact of multiple displacement amplification on microbial ecology, The ISME Journal, vol.42, issue.3, pp.233-241, 2008. ,
DOI : 10.1073/pnas.89.13.5847
Shifting the genomic gold standard for the prokaryotic species definition, Proc. Natl. Acad. Sci. USA, pp.19126-19131, 2009. ,
DOI : 10.1073/pnas.0906412106
Primer on Agar-Based Microbial Imaging Mass Spectrometry, Journal of Bacteriology, vol.194, issue.22, pp.6023-6028, 2012. ,
DOI : 10.1128/JB.00823-12
Analysis of the Sorangicin Gene Cluster Reinforces the Utility of a Combined Phylogenetic/Retrobiosynthetic Analysis for Deciphering Natural Product Assembly by trans-AT PKS, ChemBioChem, vol.22, issue.13, pp.1840-1849, 2010. ,
DOI : 10.1002/cbic.201000313
Genome Mining Reveals trans-AT Polyketide Synthase Directed Antibiotic Biosynthesis in the Bacterial Phylum Bacteroidetes, ChemBioChem, vol.130, issue.18, pp.2506-2512, 2010. ,
DOI : 10.1002/cbic.201000542
Discovery of the Rhizopodin Biosynthetic Gene Cluster in Stigmatella aurantiaca Sg a15 by Genome Mining, ChemBioChem, vol.17, issue.3, pp.416-426, 2012. ,
DOI : 10.1002/cbic.201100575
Boronated tartrolon antibiotic produced by symbiotic cellulose-degrading bacteria in shipworm gills, Proc. Natl. Acad. Sci. USA, pp.295-304, 2013. ,
DOI : 10.1073/pnas.1213892110
Conserved Amino Acid Residues Correlating With Ketoreductase Stereospecificity in Modular Polyketide Synthases, ChemBioChem, vol.111, issue.7, pp.654-657, 2003. ,
DOI : 10.1002/cbic.200300581
A Model of Structure and Catalysis for Ketoreductase Domains in Modular Polyketide Synthases, Biochemistry, vol.42, issue.1, pp.72-79, 2003. ,
DOI : 10.1021/bi0268706
Crystal Structure of the Erythromycin Polyketide Synthase Dehydratase, Journal of Molecular Biology, vol.384, issue.4, pp.941-953, 2008. ,
DOI : 10.1016/j.jmb.2008.09.084
An Enzymatic Domain for the Formation of Cyclic Ethers in Complex Polyketides, Angewandte Chemie International Edition, vol.126, issue.50, pp.13215-13218, 2013. ,
DOI : 10.1002/anie.201307406
Tolytoxin and New Scytophycins from Three Species of Scytonema, Journal of Natural Products, vol.53, issue.6, pp.1533-1542, 1990. ,
DOI : 10.1021/np50072a021
Computational identification and analysis of orphan assembly-line polyketide synthases, The Journal of Antibiotics, vol.20, issue.1, pp.89-97, 2014. ,
DOI : 10.1021/ja210202y
A Dehydratase Domain in Ambruticin Biosynthesis Displays Additional Activity as a Pyran-Forming Cyclase, Angewandte Chemie International Edition, vol.124, issue.51, pp.14240-14244, 2014. ,
DOI : 10.1002/anie.201407979
Calyculin biogenesis from a pyrophosphate protoxin produced by a sponge symbiont, Nature Chemical Biology, vol.173, issue.8, pp.648-655, 2014. ,
DOI : 10.1093/nar/27.23.4636
Metagenomic natural product discovery in lichen provides evidence for specialized biosynthetic pathways in diverse symbioses, Proc. Natl. Acad. Sci. USA, pp.3129-3137, 2013. ,
Defensive Bacteriome Symbiont with a Drastically Reduced Genome, Current Biology, vol.23, issue.15, pp.1478-1484, 2013. ,
DOI : 10.1016/j.cub.2013.06.027
Evolutionary Implications of Bacterial Polyketide Synthases, Molecular Biology and Evolution, vol.22, issue.10, pp.2027-2039, 2005. ,
DOI : 10.1093/molbev/msi193
AT Polyketide Synthases, Angewandte Chemie International Edition, vol.68, issue.4, pp.1143-1147, 2013. ,
DOI : 10.1002/anie.201207690
Amino acid-accepting ketosynthase domain from a trans-AT polyketide synthase exhibits high selectivity for predicted intermediate, Chemical Science, vol.393, issue.8, pp.3212-3217, 2013. ,
DOI : 10.1039/c3sc50540e
-Acyltransferase Polyketide Synthases, Angewandte Chemie International Edition, vol.43, issue.6, pp.1817-1821, 2015. ,
DOI : 10.1002/anie.201410219
URL : https://hal.archives-ouvertes.fr/in2p3-00309474
Synthetic Mimetics of Actin-Binding Macrolides: Rational Design of Actin-Targeted Drugs, Chemistry & Biology, vol.15, issue.3, pp.287-294, 2008. ,
DOI : 10.1016/j.chembiol.2008.01.010
Uemura for a generous sample of luminaolide, M. Wilson for sequence analysis and naming of 'Entotheonella serta' , C. Maufrais and A. Criscuolo from the Bioinformatic Plateform of the Institut Pasteur for help in ANI calculation, and J. Pernthaler for helpful discussion and for providing material for CARD-FISH experiments. We are also grateful to Y.I. Park and J.-F. Humbert for the use of cyanobacterial genomes, This work was funded by grants of the SNF (IZLSZ3_149025), and the EU (BlueGenics and BluePharmTrain) to J.P., by the Institut Pasteur to M.G ,
CHARACTERIZATION AND BIOLOGICAL IMPLICATIONS OF SCYTONEMIN, A CYANOBACTERIAL SHEATH PIGMENT1, Journal of Phycology, vol.27, issue.3, pp.395-409, 1991. ,
DOI : 10.1111/j.0022-3646.1991.00395.x
A polyphasic approach leading to the revision of the genus Planktothrix (Cyanobacteria) and its type species, P. agardhii, and proposal for integrating the emended valid botanical taxa, as well as three new species, Planktothrix paucivesiculata sp. nov.ICNP, Planktothrix tepida sp. nov.ICNP, and Planktothrix serta sp. nov.ICNP, as genus and species names with nomenclatural standing under the ICNP, Planktothrix paucivesiculata sp. nov.ICNP, Planktothrix tepida sp. nov.ICNP, and Planktothrix serta sp. nov.ICNP, as genus and species names with nomenclatural standing under the ICNP, pp.141-158, 2015. ,
DOI : 10.1016/j.syapm.2015.02.004
Generic Assignments, Strain Histories and Properties of Pure Cultures of Cyanobacteria, Microbiology, vol.111, issue.1, pp.1-61, 1979. ,
DOI : 10.1099/00221287-111-1-1
Synthesis of RNA by dissociated cells of the sea urchin embryo, Experimental Cell Research, vol.70, issue.2, pp.423-430, 1972. ,
DOI : 10.1016/0014-4827(72)90155-3
mathFISH, a Web Tool That Uses Thermodynamics-Based Mathematical Models for In Silico Evaluation of Oligonucleotide Probes for Fluorescence In Situ Hybridization, Applied and Environmental Microbiology, vol.77, issue.3, pp.1118-1122, 2011. ,
DOI : 10.1128/AEM.01733-10
Fluorescence in situ hybridization of 16S rRNA gene clones (Clone-FISH) for probe validation and screening of clone libraries, Environmental Microbiology, vol.16, issue.11, pp.713-720, 2002. ,
DOI : 10.1046/j.1462-2920.2002.00364.x
DNA Probes: Applications of the Principles of Nucleic Acid Hybridization, Critical Reviews in Biochemistry and Molecular Biology, vol.8, issue.3-4, pp.227-259, 1991. ,
DOI : 10.1002/bio.1170040121
Fluorescence In Situ Hybridization and Catalyzed Reporter Deposition for the Identification of Marine Bacteria, Applied and Environmental Microbiology, vol.68, issue.6, pp.3094-3101, 2002. ,
DOI : 10.1128/AEM.68.6.3094-3101.2002
Mass spectral molecular networking of living microbial colonies, Proc. Natl. Acad. Sci. USA, pp.1743-1752, 2012. ,
DOI : 10.1073/pnas.1203689109