HAL will be down for maintenance from Friday, June 10 at 4pm through Monday, June 13 at 9am. More information
Skip to Main content Skip to Navigation
Journal articles

Plasma apolipoprotein H limits HCV replication and associates with response to NS3 protease inhibitors-based therapy

Abstract : BACKGROUND & AIMS: Chronic infection with HCV remains a public health problem with approximately 150 million people infected worldwide. HCV intersects with lipid metabolism for replication and entry; and plasma concentrations of apolipoproteins have been identified as predictors for response to therapy. Herein, we conducted a screen of plasma proteins, including all apolipoproteins, to identify correlates of response to pegylated-interferon/ribavirin (PR) and HCV non-structural protein 3 (NS3) inhibitors (i.e., telaprevir/boceprevir) therapy in treatment-experienced cirrhotic patients from the ANRS CUPIC cohort. METHODS: We analysed 220 baseline plasma protein concentrations in 189 patients using Luminex technology and analyzed results. RESULTS: We identified baseline levels of apolipoprotein H (apoH) as a surrogate marker for sustained virological response (SVR). Notably, increased plasma concentration of apoH, used in combination with known clinical parameters, established a robust model with improved classification of patients as likely to achieve SVR (AUC = 0.77, Se = 66%, Sp = 72%, NRI = 39%). Moreover, we provide mechanistic information that indicates a previously unidentified role for apoH during viral entry. Using a human liver slices HCV infection model, we demonstrate that apoH limits replication. CONCLUSION: These data support testing of new biomarker strategies for the management of cirrhotic HCV patients and expand our understanding of how apoH may intersect with HCV infection
Document type :
Journal articles
Complete list of metadata

Contributor : Marie-Christine Vougny Connect in order to contact the contributor
Submitted on : Thursday, October 13, 2016 - 3:28:35 PM
Last modification on : Thursday, April 7, 2022 - 10:10:32 AM

Links full text



Philippe Sultanik, Vincent Mallet, Sylvie Lagaye, Armanda Casrouge, Céline Dorival, et al.. Plasma apolipoprotein H limits HCV replication and associates with response to NS3 protease inhibitors-based therapy. Liver International, Wiley-Blackwell, 2015, 35 (7), pp.1833 - 1844. ⟨10.1111/liv.12759⟩. ⟨pasteur-01380846⟩



Record views