. F. Baumann, is supported by a MENESR (Ministère Français de l'Éducation Nationale, de l'Enseignement Supérieur et de la Recherche) fellowship, C.B. and J-M.G. are supported by the Institut Pasteur

C. O. Laboratoire-d-'excellence and J. M. , (grant n°ANR-10-LABX-62-IBEID) and from Fondation pour la Recherche Médicale grantEquipe FRM DEQ20140329508 are greatful to the Spanish Ministerio de Economía y Competitividad (contract numbers SAF2013-44021-R and CTQ2010-15848), the Junta de Andalucía (contract number FQM2012 1467) and the European Regional Development Funds (FEDER and FSE) for financial support. We also acknowledge support from the European Union through the FP7-PEOPLE-2010-IRSES action Photorelease, Integrative Biology of Emerging Infectious Diseases

A. Lebeaux, O. Chauhan, and . Rendueles, From in vitro to in vivo Models of Bacterial Biofilm-Related Infections, Pathogens, vol.2, issue.2, pp.288-356, 2013.
DOI : 10.3390/pathogens2020288

URL : https://hal.archives-ouvertes.fr/pasteur-01385428

O. 'toole, H. B. Kaplan, and R. Kolter, Annual review of microbiology, pp.54-103, 2000.

J. M. Lebeaux and . Ghigo, Biofilm-Related Infections: Bridging the Gap between Clinical Management and Fundamental Aspects of Recalcitrance toward Antibiotics, Microbiology and Molecular Biology Reviews, vol.78, issue.3, pp.510-543, 2014.
DOI : 10.1128/MMBR.00013-14

URL : https://hal.archives-ouvertes.fr/pasteur-01370744

J. B. Rendueles, J. M. Kaplan, and . Ghigo, Antibiofilm polysaccharides, Environmental Microbiology, vol.39, issue.2, pp.334-346, 2013.
DOI : 10.1111/j.1462-2920.2012.02810.x

URL : https://hal.archives-ouvertes.fr/hal-01001499

M. Totsika, T. J. Kostakioti, M. Hannan, S. A. Upton, J. W. Beatson et al., A FimH Inhibitor Prevents Acute Bladder Infection and Treats Chronic Cystitis Caused by Multidrug-Resistant Uropathogenic Escherichia coli ST131, Journal of Infectious Diseases, vol.208, issue.6, pp.921-928, 2013.
DOI : 10.1093/infdis/jit245

P. Allaker and K. Memarzadeh, Nanoparticles and the control of oral infections, International Journal of Antimicrobial Agents, vol.43, issue.2, pp.95-104, 2014.
DOI : 10.1016/j.ijantimicag.2013.11.002

M. Chernousova and . Epple, Silver as Antibacterial Agent: Ion, Nanoparticle, and Metal, Angewandte Chemie International Edition, vol.45, issue.6, pp.1636-1653, 2013.
DOI : 10.1002/anie.201205923

G. Francolini and . Donelli, Prevention and control of biofilm-based medical-device-related infections, FEMS Immunology & Medical Microbiology, vol.59, issue.3, pp.227-238, 2010.
DOI : 10.1111/j.1574-695X.2010.00665.x

A. P. Herman and . Herman, Nanoparticles as Antimicrobial Agents: Their Toxicity and Mechanisms of Action, Journal of Nanoscience and Nanotechnology, vol.14, issue.1, pp.946-957, 2014.
DOI : 10.1166/jnn.2014.9054

M. Klemm, A. Schembri, R. Böck, I. Curtiss, J. B. Kaper et al., Type 1 Fimbriae, Curli, and Antigen 43: Adhesion, Colonization, and Biofilm Formation, EcoSal-Escherichia coli and Salmonella: cellular and molecular biology, 2004.
DOI : 10.1128/ecosalplus.

R. Wu, T. T. Sun, and J. J. Medina, In vitro binding of type 1-fimbriated Escherichia coli to uroplakins Ia and Ib: relation to urinary tract infections., Proceedings of the National Academy of Sciences, vol.93, issue.18, pp.9630-9635, 1996.
DOI : 10.1073/pnas.93.18.9630

D. L. Ofek, N. Hasty, and . Sharon, Anti-adhesion therapy of bacterial diseases: prospects and problems, FEMS Immunology & Medical Microbiology, vol.38, issue.3, pp.181-191, 2003.
DOI : 10.1016/S0928-8244(03)00228-1

J. S. Han, B. Pinkner, E. Ford, J. M. Chorell, C. K. Crowley et al., Lead Optimization Studies on FimH Antagonists: Discovery of Potent and Orally Bioavailable Ortho-Substituted Biphenyl Mannosides, Journal of Medicinal Chemistry, vol.55, issue.8, pp.3945-3959, 2012.
DOI : 10.1021/jm300165m

D. Jiang, S. Abgottspon, S. Kleeb, M. Rabbani, M. Scharenberg et al., Antiadhesion Therapy for Urinary Tract Infections???A Balanced PK/PD Profile Proved To Be Key for Success, Journal of Medicinal Chemistry, vol.55, issue.10, pp.4700-4713, 2012.
DOI : 10.1021/jm300192x

R. T. Nagahori, S. Lee, D. Nishimura, R. Page, Y. C. Roy et al., Inhibition of Adhesion of Type 1 Fimbriated Escherichia coli to Highly Mannosylated Ligands, ChemBioChem, vol.3, issue.9, pp.836-844, 2002.
DOI : 10.1002/1439-7633(20020902)3:9<836::AID-CBIC836>3.0.CO;2-2

T. K. Patel and . Lindhorst, Multivalent glycomimetics: synthesis of nonavalent mannoside clusters with variation of spacer properties, Carbohydrate Research, vol.341, issue.10, pp.1657-1668, 2006.
DOI : 10.1016/j.carres.2006.01.024

A. Touaibia, T. C. Wellens, Q. Shiao, S. Wang, J. Sirois et al., Mannosylated G(0) Dendrimers with Nanomolar Affinities toEscherichia coli FimH, ChemMedChem, vol.55, issue.8, pp.1190-1201, 2007.
DOI : 10.1002/cmdc.200700063

L. Kiessling, J. E. Gestwicki, and L. E. Strong, Synthetic multivalent ligands in the exploration of cell-surface interactions, Current Opinion in Chemical Biology, vol.4, issue.6, pp.696-703, 2000.
DOI : 10.1016/S1367-5931(00)00153-8

J. Lundquist and E. J. Toone, The Cluster Glycoside Effect, Chemical Reviews, vol.102, issue.2, pp.555-578, 2002.
DOI : 10.1021/cr000418f

S. Mammen, G. M. Choi, and . Whitesides, Polyvalent Interactions in Biological Systems: Implications for Design and Use of Multivalent Ligands and Inhibitors, Angewandte Chemie International Edition, vol.37, issue.20, pp.2754-2899, 1998.
DOI : 10.1002/(SICI)1521-3773(19981102)37:20<2754::AID-ANIE2754>3.0.CO;2-3

C. Lee and R. T. Lee, Carbohydrate-Protein Interactions: Basis of Glycobiology, Accounts of Chemical Research, vol.28, issue.8, pp.321-327, 1995.
DOI : 10.1021/ar00056a001

A. Mintzer, E. L. Dane, G. A. O-'toole, and M. W. Grinstaff, Exploiting Dendrimer Multivalency To Combat Emerging and Re-Emerging Infectious Diseases, Molecular Pharmaceutics, vol.9, issue.3, pp.342-354, 2012.
DOI : 10.1021/mp2005033

P. Hartmann, Y. Betz, S. N. Sun, T. K. Gorb, A. Lindhorst et al., Saccharide-Modified Nanodiamond Conjugates for the Efficient Detection and Removal of Pathogenic Bacteria, Chemistry - A European Journal, vol.3, issue.21, pp.6485-6492, 2012.
DOI : 10.1002/chem.201104069

S. Barras, L. Szunerits, N. Marcon, R. Monfilliette-dupont, and . Boukherroub, Functionalization of Diamond Nanoparticles Using ???Click??? Chemistry, Langmuir, vol.26, issue.16, pp.13168-13172, 2010.
DOI : 10.1021/la101709q

R. Chang, H. Y. Lee, K. Chen, C. C. Chang, D. S. Tsai et al., Mass production and dynamic imaging of fluorescent nanodiamonds, Nature Nanotechnology, vol.127, issue.5, pp.284-288, 2008.
DOI : 10.1038/nnano.2008.99

M. Liang, A. Ozawa, and . Krueger, A General Procedure to Functionalize Agglomerating Nanoparticles Demonstrated on Nanodiamond, ACS Nano, vol.3, issue.8, pp.2288-2296, 2009.
DOI : 10.1021/nn900339s

N. Mochalin, O. Shenderova, D. Ho, and Y. Gogotsi, The properties and applications of nanodiamonds, Nature Nanotechnology, vol.3, issue.1, pp.11-23, 2012.
DOI : 10.1038/nnano.2011.209

F. Marcon, D. Riquet, S. Vicogne, J. Szunerits, R. Bodart et al., Cellular and in vivo toxicity of functionalized nanodiamond in Xenopus embryos, Journal of Materials Chemistry, vol.6, issue.37, pp.8064-8069, 2010.
DOI : 10.1039/c0jm01570a

-. Liu, C. Cheng, C. C. Chang, and J. Chao, Biocompatible and detectable carboxylated nanodiamond on human cell, Nanotechnology, vol.18, issue.32, p.325102, 2007.
DOI : 10.1088/0957-4484/18/32/325102

J. Yu, M. W. Kang, H. C. Chang, K. M. Chen, and Y. C. Yu, Bright Fluorescent Nanodiamonds:?? No Photobleaching and Low Cytotoxicity, Journal of the American Chemical Society, vol.127, issue.50, pp.17604-17605, 2005.
DOI : 10.1021/ja0567081

C. Wellens, H. Garofalo, N. Nguyen, R. Van-gerven, J. P. Slattegard et al., Intervening with Urinary Tract Infections Using Anti-Adhesives Based on the Crystal Structure of the FimH???Oligomannose-3 Complex, PLoS ONE, vol.165, issue.4, p.2040, 2008.
DOI : 10.1371/journal.pone.0002040.s002

M. Benito, M. Gomez-garcia, C. Ortiz-mellet, I. Baussanne, J. Defaye et al., Optimizing Saccharide-Directed Molecular Delivery to Biological Receptors:?? Design, Synthesis, and Biological Evaluation of Glycodendrimer???Cyclodextrin Conjugates, Journal of the American Chemical Society, vol.126, issue.33, pp.10355-10363, 2004.
DOI : 10.1021/ja047864v

C. Martinez, J. M. Ortiz-mellet, . Garcia, and . Fernandez, Cyclodextrin-based multivalent glycodisplays: covalent and supramolecular conjugates to assess carbohydrate???protein interactions, Chemical Society Reviews, vol.56, issue.11, pp.4746-4773, 2013.
DOI : 10.1039/c2cs35219b

H. Schlick, J. R. Morgan, J. J. Weiel, M. S. Kelsey, and M. J. Cloninger, Clusters of ligands on dendrimer surfaces, Bioorganic & Medicinal Chemistry Letters, vol.21, issue.17, pp.5078-5083, 2011.
DOI : 10.1016/j.bmcl.2011.03.100

G. Korea, R. Badouraly, M. C. Prevost, J. M. Ghigo, and C. Beloin, Escherichia coli K-12 possesses multiple cryptic but functional chaperone-usher fimbriae with distinct surface specificities, Environmental Microbiology, vol.93, issue.7, pp.1957-1977, 2010.
DOI : 10.1111/j.1462-2920.2010.02202.x

URL : https://hal.archives-ouvertes.fr/pasteur-01393508

A. Pratt and R. Kolter, biofilm formation: roles of flagella, motility, chemotaxis and type I pili, Molecular Microbiology, vol.86, issue.2, pp.285-293, 1998.
DOI : 10.1046/j.1365-2958.1998.01061.x