Molecular Basis of NF-??B Signaling, Annual Review of Biophysics, vol.42, issue.1, pp.443-468, 2013. ,
DOI : 10.1146/annurev-biophys-083012-130338
IKK Regulation and Human Genetics, Curr. Top. Microbiol. Immunol, vol.349, pp.73-95, 2011. ,
DOI : 10.1007/82_2010_98
Crosstalk in NF-??B signaling pathways, Nature Immunology, vol.13, issue.8, pp.695-708, 2011. ,
DOI : 10.1016/j.cell.2007.07.009
Higher-Order Assemblies in a New Paradigm of Signal Transduction, Cell, vol.153, issue.2, pp.287-292, 2013. ,
DOI : 10.1016/j.cell.2013.03.013
The Structure and Dynamics of Higher-Order Assemblies: Amyloids, Signalosomes, and Granules, Cell, vol.165, issue.5, pp.1055-1066, 2016. ,
DOI : 10.1016/j.cell.2016.05.004
E2 interaction and dimerization in the crystal structure of TRAF6, Nature Structural & Molecular Biology, vol.21, issue.6, pp.658-666, 2009. ,
DOI : 10.1107/S0021889800014126
Structural Insights into the Assembly of Large Oligomeric Signalosomes in the Toll-Like Receptor-Interleukin-1 Receptor Superfamily, Science Signaling, vol.5, issue.226, p.3, 2012. ,
DOI : 10.1126/scisignal.2003124
Complementation Cloning of NEMO, a Component of the I??B Kinase Complex Essential for NF-??B Activation, Cell, vol.93, issue.7, pp.1231-1240, 1998. ,
DOI : 10.1016/S0092-8674(00)81466-X
IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex, Nature, vol.395, pp.297-300, 1998. ,
TNF and IL-1 exhibit distinct ubiquitin requirements for inducing NEMO???IKK supramolecular structures, The Journal of Cell Biology, vol.19, issue.2, pp.231-245, 2014. ,
DOI : 10.1016/S1074-7613(00)80183-1
NEMO oligomerization in the dynamic assembly of the I??B kinase core complex, FEBS Journal, vol.284, issue.10, pp.2540-2551, 2007. ,
DOI : 10.1111/j.1742-4658.2007.05788.x
NEMO oligomerization and its ubiquitin-binding properties, Biochemical Journal, vol.5, issue.2, pp.243-251, 2009. ,
DOI : 10.1016/j.molcel.2008.04.029
Molecular control of the NEMO family of ubiquitin-binding proteins, Nature Reviews Molecular Cell Biology, vol.267, issue.10, pp.673-685, 2013. ,
DOI : 10.1111/j.1600-065X.2011.01088.x
Crystal structure of inhibitor of ??B kinase ??, Nature, vol.20, issue.7343, pp.325-330, 2011. ,
DOI : 10.1038/nature09853
A Structural Basis for I??B Kinase 2 Activation Via Oligomerization-Dependent Trans Auto-Phosphorylation, PLoS Biology, vol.66, issue.6, p.1001581, 2013. ,
DOI : 10.1371/journal.pbio.1001581.s005
Alterations of the IKBKG locus and diseases: an update and a report of 13 novel mutations, Human Mutation, vol.67, issue.5, pp.595-604, 2008. ,
DOI : 10.1002/humu.20739
A recurrent deletion in the ubiquitously expressed NEMO (IKK-gamma) gene accounts for the vast majority of incontinentia pigmenti mutations, Human Molecular Genetics, vol.10, issue.19, pp.2171-2179, 2001. ,
DOI : 10.1093/hmg/10.19.2171
Identification of TRAF6-dependent NEMO polyubiquitination sites through analysis of a new NEMO mutation causing incontinentia pigmenti, Human Molecular Genetics, vol.16, issue.23, pp.2805-2815, 2007. ,
DOI : 10.1093/hmg/ddm237
PALM and STORM: What hides beyond the Rayleigh limit?, Biotechnology Journal, vol.36, issue.6, pp.846-857, 2009. ,
DOI : 10.1002/biot.200900024
Probing the Solution Structure of I??B Kinase (IKK) Subunit ?? and Its Interaction with Kaposi Sarcoma-associated Herpes Virus Flice-interacting Protein and IKK Subunit ?? by EPR Spectroscopy, Journal of Biological Chemistry, vol.290, issue.27, pp.16539-16549, 2015. ,
DOI : 10.1074/jbc.M114.622928
Imaging Intracellular Fluorescent Proteins at Nanometer Resolution, Science, vol.313, issue.5793, pp.1642-1645, 2006. ,
DOI : 10.1126/science.1127344
Sub-diffraction-limit imaging by stochastic optical reconstruction microscopy (STORM), Nature Methods, vol.127, issue.10, pp.793-795, 2006. ,
DOI : 10.1038/nmeth929
Super-resolution fluorescence imaging with single molecules, Current Opinion in Structural Biology, vol.23, issue.5, pp.778-787, 2013. ,
DOI : 10.1016/j.sbi.2013.07.010
Cellular Inclusion Bodies of Mutant Huntingtin Exon 1 Obscure Small Fibrillar Aggregate Species, Scientific Reports, vol.100, p.895, 2012. ,
DOI : 10.1038/srep00895
Subdiffraction-Resolution Fluorescence Imaging with Conventional Fluorescent Probes, Angewandte Chemie International Edition, vol.2, issue.33, pp.6172-6176, 2008. ,
DOI : 10.1002/anie.200802376
Fast, backgroundfree , 3D super-resolution optical fluctuation imaging (SOFI), Proc. Natl Acad. Sci. USA, pp.22287-22292, 2009. ,
The Zinc Finger of NEMO Is a Functional Ubiquitin-binding Domain, Journal of Biological Chemistry, vol.284, issue.5, pp.2902-2907, 2009. ,
DOI : 10.1074/jbc.M806655200
URL : https://hal.archives-ouvertes.fr/pasteur-00366746
NEMO specifically recognizes K63-linked poly-ubiquitin chains through a new bipartite ubiquitin-binding domain, The EMBO Journal, vol.28, issue.19, pp.2885-2895, 2009. ,
DOI : 10.1016/j.cub.2007.07.041
Structural Basis for Recognition of Diubiquitins by NEMO, Molecular Cell, vol.33, issue.5, pp.602-615, 2009. ,
DOI : 10.1016/j.molcel.2009.01.012
NF-??B Essential Modulator (NEMO) Interaction with Linear and Lys-63 Ubiquitin Chains Contributes to NF-??B Activation, Journal of Biological Chemistry, vol.286, issue.29, pp.26107-26117, 2011. ,
DOI : 10.1074/jbc.M111.233163
SHARPIN forms a linear ubiquitin ligase complex regulating NF-??B activity and apoptosis, Nature, vol.2, issue.7340, pp.637-641, 2011. ,
DOI : 10.1038/nature09814
Analysis of Nuclear Factor-??B (NF-??B) Essential Modulator (NEMO) Binding to Linear and Lysine-linked Ubiquitin Chains and Its Role in the Activation of NF-??B, Journal of Biological Chemistry, vol.287, issue.28, pp.23626-23634, 2012. ,
DOI : 10.1074/jbc.M112.347195
NEMO is a sensor of Lys 63-linked polyubiquitination and functions in NF-??B activation, Nature Cell Biology, vol.101, issue.4, pp.398-406, 2006. ,
DOI : 10.1038/ncb1384
Specific Recognition of Linear Ubiquitin Chains by NEMO Is Important for NF-??B Activation, Cell, vol.136, issue.6, pp.1098-1109, 2009. ,
DOI : 10.1016/j.cell.2009.03.007
Inhibition of NF-??B Activation by Peptides Targeting NF-??B Essential Modulator (NEMO) Oligomerization, Journal of Biological Chemistry, vol.279, issue.52, pp.54248-54257, 2004. ,
DOI : 10.1074/jbc.M406423200
URL : https://hal.archives-ouvertes.fr/pasteur-00166822
Impediment of NEMO oligomerization inhibits osteoclastogenesis and osteolysis, Journal of Cellular Biochemistry, vol.8, issue.35, pp.1337-1345, 2009. ,
DOI : 10.1002/jcb.22364
Cellular ubiquitin pool dynamics and homeostasis, BMB Reports, vol.47, issue.9, pp.475-482, 2014. ,
DOI : 10.5483/BMBRep.2014.47.9.128
The tumour suppressor CYLD negatively regulates NF-??B signalling by deubiquitination, Nature, vol.424, issue.6950, pp.801-805, 2003. ,
DOI : 10.1038/nature01802
Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains, EMBO reports, vol.10, issue.5, pp.466-473, 2009. ,
DOI : 10.1038/sj.onc.1211042
OTULIN Antagonizes LUBAC Signaling by Specifically Hydrolyzing Met1-Linked Polyubiquitin, Cell, vol.153, issue.6, pp.1312-1326, 2013. ,
DOI : 10.1016/j.cell.2013.05.014
Direct inhibition of NF-??B activation by peptide targeting the NOA ubiquitin binding domain of NEMO, Biochemical Pharmacology, vol.82, issue.9, pp.1163-1174, 2011. ,
DOI : 10.1016/j.bcp.2011.07.083
Recruitment of the IKK Signalosome to the p55 TNF Receptor, Immunity, vol.12, issue.3, pp.301-311, 2000. ,
DOI : 10.1016/S1074-7613(00)80183-1
Selective Inhibition of NF-kappa B Activation by a Peptide That Blocks the Interaction of NEMO with the Ikappa B Kinase Complex, Science, vol.289, issue.5484, pp.1550-1554, 2000. ,
DOI : 10.1126/science.289.5484.1550
Genomic rearrangement in NEMO impairs NF-kappaB activation and is a cause of incontinentia pigmenti. The International Incontinentia Pigmenti (IP) Consortium, Nature, vol.405, pp.466-472, 2000. ,
Locus: Report of New Mutations and Complex Genomic Rearrangements Leading to Incontinentia Pigmenti Disease, Human Mutation, vol.31, issue.Web Server issu, pp.165-177, 2014. ,
DOI : 10.1002/humu.22483
Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains, Proc. Natl Acad. Sci. USA, pp.15247-15252, 2013. ,
DOI : 10.1073/pnas.1314715110
Protein standard absolute quantification (PSAQ) method for the measurement of cellular ubiquitin pools, Nature Methods, vol.10, issue.8, pp.691-696, 2011. ,
DOI : 10.1038/nprot.2007.202
Single-cell NF-??B dynamics reveal digital activation and analogue information processing, Nature, vol.6, issue.7303, pp.267-271, 2010. ,
DOI : 10.1038/nature09145
Predicting coiled coils from protein sequences, Science, vol.252, issue.5009, pp.1162-1164, 1991. ,
DOI : 10.1126/science.252.5009.1162
Paircoil2: improved prediction of coiled coils from sequence, Bioinformatics, vol.22, issue.3, pp.356-358, 2006. ,
DOI : 10.1093/bioinformatics/bti797
SOCKET: a program for identifying and analysing coiled-coil motifs within protein structures11Edited by J. Thornton, Journal of Molecular Biology, vol.307, issue.5, pp.1427-1450, 2001. ,
DOI : 10.1006/jmbi.2001.4545
Improved methods for building protein models in electron density maps and the location of errors in these models, Acta Crystallographica Section A Foundations of Crystallography, vol.47, issue.2, pp.110-119, 1991. ,
DOI : 10.1107/S0108767390010224
CCBuilder: an interactive web-based tool for building, designing and assessing coiled-coil protein assemblies, Bioinformatics, vol.30, issue.21, pp.3029-3035, 2014. ,
DOI : 10.1093/bioinformatics/btu502
Crystal structure of the NEMO ubiquitin-binding domain in complex with Lys 63-linked di-ubiquitin, FEBS Letters, vol.2006, issue.20, pp.3317-3322, 2009. ,
DOI : 10.1016/j.febslet.2009.09.028
Two-sided Ubiquitin Binding of NF-??B Essential Modulator (NEMO) Zinc Finger Unveiled by a Mutation Associated with Anhidrotic Ectodermal Dysplasia with Immunodeficiency Syndrome, Journal of Biological Chemistry, vol.288, issue.47, pp.33722-33737, 2013. ,
DOI : 10.1074/jbc.M113.483305
Structure of a NEMO/IKK-Associating Domain Reveals Architecture of the Interaction Site, Structure, vol.16, issue.5, pp.798-808, 2008. ,
DOI : 10.1016/j.str.2008.02.012
QuickPALM: 3D real-time photoactivation nanoscopy image processing in ImageJ, Nature Methods, vol.47, issue.5, pp.339-340, 2010. ,
DOI : 10.1038/nmeth0510-339
Computer control of microscopes using mManager, Curr. Protoc. Mol. Biol. Chapter, p.20, 2010. ,
Fiji: an open-source platform for biological-image analysis, Nature Methods, vol.27, issue.7, pp.676-682, 2012. ,
DOI : 10.1038/nmeth.2019
Image thresholding by minimizing the measures of fuzziness. Pattern Recogn, pp.41-51, 1995. ,