Transport across the primate blood-brain barrier of a genetically engineered chimeric monoclonal antibody to the human insulin receptor, Pharmaceutical Research, vol.17, issue.3, pp.266-74, 2000. ,
DOI : 10.1023/A:1007592720793
Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease, Nature Medicine, vol.6, issue.8, pp.916-91078682, 1038. ,
DOI : 10.1038/78682
Increased Brain Penetration and Potency of a Therapeutic Antibody Using a Monovalent Molecular Shuttle, Neuron, vol.81, issue.1, pp.81-130, 2014. ,
DOI : 10.1016/j.neuron.2013.10.061
Blood-Brain Barrier Molecular Trojan Horse Enables Imaging of Brain Uptake of Radioiodinated Recombinant Protein in the Rhesus Monkey, Bioconjugate Chemistry, vol.24, issue.10, pp.1741-1750, 2013. ,
DOI : 10.1021/bc400319d
Addressing Safety Liabilities of TfR Bispecific Antibodies That Cross the Blood-Brain Barrier, Science Translational Medicine, vol.5, issue.183, pp.183-57, 2013. ,
DOI : 10.1126/scitranslmed.3005338
A Monoclonal Antibody-GDNF Fusion Protein Is Not Neuroprotective and Is Associated with Proliferative Pancreatic Lesions in Parkinsonian Monkeys, PLoS ONE, vol.23, issue.6 ,
DOI : 10.1371/journal.pone.0039036.t001
Fast in vivo imaging of amyloid plaques using ??-MRI Gd-staining combined with ultrasound-induced blood???brain barrier opening, NeuroImage, vol.79, pp.288-94, 2013. ,
DOI : 10.1016/j.neuroimage.2013.04.106
Gadolinium-complexed A??-binding contrast agents for MRI diagnosis of Alzheimer's Disease, Neuropeptides, vol.53, 2015. ,
DOI : 10.1016/j.npep.2015.07.001
A non-toxic ligand for voxel-based MRI analysis of plaques in AD transgenic mice, Neurobiology of Aging, vol.29, issue.6, pp.836-847, 2008. ,
DOI : 10.1016/j.neurobiolaging.2006.12.018
Neurosurgical Techniques for Disruption of the Blood???Brain Barrier for Glioblastoma Treatment, Pharmaceutics, vol.7, issue.3, pp.175-87, 2015. ,
DOI : 10.3390/pharmaceutics7030175
Naturally occurring antibodies devoid of light chains, Nature, vol.363, issue.6428, pp.446-454, 1993. ,
DOI : 10.1038/363446a0
Nanobodies: Natural Single-Domain Antibodies, Annual Review of Biochemistry, vol.82, issue.1, p.20 ,
DOI : 10.1146/annurev-biochem-063011-092449
Llama VHH antibody fragments against GFAP: better diffusion in fixed tissues than classical monoclonal antibodies, Acta Neuropathologica, vol.4, issue.5, pp.685-95, 2009. ,
DOI : 10.1007/s00401-009-0572-6
URL : https://hal.archives-ouvertes.fr/pasteur-00429632
Efficient tumor targeting by single-domain antibody fragments of camels, International Journal of Cancer, vol.78, issue.3, pp.98-456, 2002. ,
DOI : 10.1002/ijc.10212
Influence of molecular size on tissue distribution of antibody fragments, mAbs, vol.40, issue.1, pp.113-122, 2015. ,
DOI : 10.1152/ajprenal.00171.2004
Targeting and tracing antigens in live cells with fluorescent nanobodies, Nature Methods, vol.414, issue.11, pp.887-896, 2006. ,
DOI : 10.1038/nmeth953
Direct and Dynamic Detection of HIV-1 in Living Cells, PLoS ONE, vol.12, issue.11 ,
DOI : 10.1371/journal.pone.0050026.s001
Cell-penetrating anti-GFAP VHH and corresponding fluorescent fusion protein VHH-GFP spontaneously cross the blood-brain barrier and specifically recognize astrocytes: application to brain imaging, The FASEB Journal, vol.26, issue.10, pp.3969-7911, 2012. ,
DOI : 10.1096/fj.11-201384
URL : https://hal.archives-ouvertes.fr/pasteur-01373103
Mapping cytoskeletal protein function in cells by means of nanobodies, Cytoskeleton, vol.448, issue.1, pp.604-626, 2013. ,
DOI : 10.1002/cm.21122
Fluorescent labelling of the actin cytoskeleton in plants using a cameloid antibody., Plant Methods, pp.10-1186, 2014. ,
Monitoring Interactions and Dynamics of Endogenous Beta-catenin With Intracellular Nanobodies in Living Cells, Molecular & Cellular Proteomics, vol.14, issue.3, pp.707-730, 2015. ,
DOI : 10.1074/mcp.M114.044016
Real-time analysis of epithelial-mesenchymal transition using fluorescent single-domain antibodies, Scientific Reports, vol.7, issue.1 ,
DOI : 10.1371/journal.pone.0033183
Single-domain antibodies recognize selectively small oligomeric forms of amyloid ??, prevent A??-induced neurotoxicity and inhibit fibril formation, Molecular Immunology, vol.46, issue.4, pp.695-704, 2009. ,
DOI : 10.1016/j.molimm.2008.09.008
Expression of Transgenic APP mRNA Is the Key Determinant for Beta-Amyloid Deposition in PS2APP Transgenic Mice, Neurodegenerative Diseases, vol.6, issue.1-2, pp.29-36, 2009. ,
DOI : 10.1159/000170884
Cortical hypoperfusion in the B6.PS2APP mouse model for Alzheimer's disease: Comprehensive phenotyping of vascular and tissular parameters by MRI, Magnetic Resonance in Medicine, vol.55, issue.1 ,
DOI : 10.1002/mrm.21985
Tau Suppression in a Neurodegenerative Mouse Model Improves Memory Function, Science, vol.309, issue.5733, pp.309-476, 2005. ,
DOI : 10.1126/science.1113694
Site-Specific Antibody???Drug Conjugates: The Nexus of Bioorthogonal Chemistry, Protein Engineering, and Drug Development, Bioconjugate Chemistry, vol.26, issue.2, pp.176-92, 2015. ,
DOI : 10.1021/bc5004982
Assessment of ??-amyloid deposits in human brain: a study of the BrainNet Europe Consortium, Acta Neuropathologica, vol.30, issue.3, pp.309-329, 2009. ,
DOI : 10.1007/s00401-009-0485-4
In Vivo Detection of Amyloid-?? Deposits Using Heavy Chain Antibody Fragments in a Transgenic Mouse Model for Alzheimer's Disease, PLoS ONE, vol.25, issue.6 ,
DOI : 10.1371/journal.pone.0038284.t005
Monoclonal antibodies with selective specificity for Alzheimer Tau are directed against phosphatase-sensitive epitopes, Acta Neuropathologica, vol.84, issue.3, pp.265-721384266, 1992. ,
DOI : 10.1007/BF00227819
Selection of phage-displayed llama single-domain antibodies that transmigrate across human blood-brain barrier endothelium, The FASEB Journal, vol.16, pp.240-242, 2002. ,
DOI : 10.1096/fj.01-0343fje
Differential recognition of vascular and parenchymal beta amyloid deposition, Neurobiology of Aging, vol.32, issue.10, pp.1774-83, 2011. ,
DOI : 10.1016/j.neurobiolaging.2009.11.012
Enhanced glutathione PEGylated liposomal brain delivery of an anti-amyloid single domain antibody fragment in a mouse model for Alzheimer's disease, Journal of Controlled Release, vol.203, pp.40-50, 2015. ,
DOI : 10.1016/j.jconrel.2015.02.012
Blood???brain-barriers in aging and in Alzheimer???s disease, Molecular Neurodegeneration, vol.8, issue.1, pp.1750-1326, 2013. ,
DOI : 10.1186/1750-1326-8-38
Lack of Widespread BBB Disruption in Alzheimer???s Disease Models: Focus on Therapeutic Antibodies, Neuron, vol.88, issue.2, pp.289-97, 2015. ,
DOI : 10.1016/j.neuron.2015.09.036
Tau depletion prevents progressive blood-brain barrier damage in a mouse model of tauopathy, Acta Neuropathologica Communications, vol.9, issue.4, 2015. ,
DOI : 10.1186/s40478-015-0186-2
Blood???brain barrier structure and function and the challenges for CNS drug delivery, Journal of Inherited Metabolic Disease, vol.16, issue.3, pp.437-486, 2013. ,
DOI : 10.1007/s10545-013-9608-0
The bloodbrain barrier transmigrating single domain antibody: mechanisms of transport and antigenic epitopes in human brain endothelial cells, J. Neurochem, vol.95, 2005. ,
Delivery of peptides and proteins through the blood???brain barrier, Advanced Drug Delivery Reviews, vol.46, issue.1-3, pp.247-79, 2001. ,
DOI : 10.1016/S0169-409X(00)00139-3
Using a Supercharged Protein, ACS Chemical Biology, vol.5, issue.8, pp.747-5210, 1021. ,
DOI : 10.1021/cb1001153
A Class of Human Proteins that Deliver Functional Proteins into Mammalian Cells In??Vitro and In??Vivo, Chemistry & Biology, vol.18, issue.7, pp.833-841, 2011. ,
DOI : 10.1016/j.chembiol.2011.07.003
Use of florbetapir-PET for imaging beta-amyloid pathology, pp.305-275, 2008. ,
PET Quantification of Tau Pathology in Human Brain with 11C-PBB3, Journal of Nuclear Medicine, vol.56, issue.9, pp.1359-65, 2015. ,
DOI : 10.2967/jnumed.115.160127
Imaging brain amyloid in Alzheimer's disease with, Pittsburgh Compound-B. Ann. Neurol, pp.55-306, 2004. ,
Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls ,
Non-invasive assessment of Alzheimer's disease neurofibrillary pathology using 18F-THK5105 PET, Brain, vol.137, issue.6, pp.1762-71, 2014. ,
DOI : 10.1093/brain/awu064
Rominger, microPET Imaging of Tau Pathology with [18F]-THK5117 in two Transgenic Mouse Models, J. Nucl. Med, vol.49, pp.1-32, 2016. ,
Antibody-based PET imaging of amyloid beta in mouse models of Alzheimer???s disease, Nature Communications, vol.135 ,
DOI : 10.1038/ncomms10759
Tetrameric and Homodimeric Camelid IgGs Originate from the Same IgH Locus, The Journal of Immunology, vol.181, issue.3, pp.2001-2010, 2008. ,
DOI : 10.4049/jimmunol.181.3.2001
URL : https://hal.archives-ouvertes.fr/pasteur-00429626
Experimental therapy of African trypanosomiasis with a nanobody-conjugated human trypanolytic factor, Nature Medicine, vol.350, issue.5, pp.580-584, 1395. ,
DOI : 10.1038/nm1395
Formatted anti???tumor necrosis factor ?? VHH proteins derived from camelids show superior potency and targeting to inflamed joints in a murine model of collagen-induced arthritis, Arthritis & Rheumatism, vol.98, issue.6, pp.1856-66, 2006. ,
DOI : 10.1002/art.21827
Efficient Cancer Therapy with a Nanobody-Based Conjugate, Cancer Research, vol.64, issue.8, pp.2853-715087403, 2004. ,
DOI : 10.1158/0008-5472.CAN-03-3935
General Strategy to Humanize a Camelid Single-domain Antibody and Identification of a Universal Humanized Nanobody Scaffold, Journal of Biological Chemistry, vol.284, issue.5, pp.3273-84, 2009. ,
DOI : 10.1074/jbc.M806889200
Novel therapy based on camelid nanobodies, Therapeutic Delivery, vol.4, issue.10, pp.1321-1357, 2013. ,
DOI : 10.4155/tde.13.87