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MHC-I-restricted presentation of HIV-1 virion antigens without viral replication.

Abstract : Dendritic cells and macrophages can process extracellular antigens for presentation by MHC-I molecules. This exogenous pathway may have a crucial role in the activation of CD8+ cytotoxic T lymphocytes during human viral infections. We show here that HIV-1 epitopes derived from incoming virions are presented through the exogenous MHC-I pathway in primary human dendritic cells, and to a lower extent in macrophages, leading to cytotoxic T-lymphocyte activation in the absence of viral protein synthesis. Exogenous antigen presentation required adequate virus-receptor interactions and fusion of viral and cellular membranes. These results provide new insights into how anti-HIV cytotoxic T lymphocytes can be activated and have implications for anti-HIV vaccine design.
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Contributor : Isma Ziani Connect in order to contact the contributor
Submitted on : Tuesday, September 27, 2016 - 3:51:45 PM
Last modification on : Thursday, April 7, 2022 - 10:10:31 AM




Florence Buseyne, Sylvie Le Gall, Claire Boccaccio, Jean-Pierre Abastado, Jeffrey D. Lifson, et al.. MHC-I-restricted presentation of HIV-1 virion antigens without viral replication.. Nature Medicine, 2001, 7 (3), pp.344-9. ⟨10.1038/85493⟩. ⟨pasteur-01372734⟩



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