Dendritic cells and HIV-specific CD4+ T cells: HIV antigen presentation, T-cell activation, and viral transfer. - Archive ouverte HAL Access content directly
Journal Articles Blood Year : 2006

Dendritic cells and HIV-specific CD4+ T cells: HIV antigen presentation, T-cell activation, and viral transfer.

Arnaud Moris
Anthony Pajot
  • Function : Author
Fabien Blanchet
Florence Guivel-Benhassine
Olivier Schwartz
  • Function : Author
  • PersonId : 999827

Abstract

Human immunodeficiency virus (HIV)-specific CD4+ lymphocytes are preferentially infected in HIV-positive individuals. To study this preferential infection, we have derived several HIV-specific (HS) CD4+ clones. We show that in dendritic cells (DCs), HIV virion capture led to major histocompatibility complex class-II (MHC-II)-restricted viral antigen presentation and to activation of HS cells. In contrast, neither cell-free virions nor infected lymphocytes activated HS cells. In DCs, the dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN/CD209), which internalizes virions, promoted MHC-II presentation of HIV antigens. Activation of HS cells by HIV-exposed DCs triggered an efficient viral spread in lymphocytes. CD4+ clones with irrelevant antigenic specificities were not activated by HIV-exposed DCs and poorly supported viral replication under this setting. Our results unravel the mechanisms of MHC-II-restricted HIV antigen presentation by DCs and describe how HIV gains access to the very cells designed by the immune system to counteract this pathogen.
Not file

Dates and versions

pasteur-01372632 , version 1 (27-09-2016)

Identifiers

Cite

Arnaud Moris, Anthony Pajot, Fabien Blanchet, Florence Guivel-Benhassine, Margarita Salcedo, et al.. Dendritic cells and HIV-specific CD4+ T cells: HIV antigen presentation, T-cell activation, and viral transfer.. Blood, 2006, 108 (5), pp.1643-51. ⟨10.1182/blood-2006-02-006361⟩. ⟨pasteur-01372632⟩

Collections

PASTEUR CNRS
28 View
0 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More