Skip to Main content Skip to Navigation
Journal articles

Dendritic cells and HIV-specific CD4+ T cells: HIV antigen presentation, T-cell activation, and viral transfer.

Abstract : Human immunodeficiency virus (HIV)-specific CD4+ lymphocytes are preferentially infected in HIV-positive individuals. To study this preferential infection, we have derived several HIV-specific (HS) CD4+ clones. We show that in dendritic cells (DCs), HIV virion capture led to major histocompatibility complex class-II (MHC-II)-restricted viral antigen presentation and to activation of HS cells. In contrast, neither cell-free virions nor infected lymphocytes activated HS cells. In DCs, the dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN/CD209), which internalizes virions, promoted MHC-II presentation of HIV antigens. Activation of HS cells by HIV-exposed DCs triggered an efficient viral spread in lymphocytes. CD4+ clones with irrelevant antigenic specificities were not activated by HIV-exposed DCs and poorly supported viral replication under this setting. Our results unravel the mechanisms of MHC-II-restricted HIV antigen presentation by DCs and describe how HIV gains access to the very cells designed by the immune system to counteract this pathogen.
Document type :
Journal articles
Complete list of metadatas

https://hal-pasteur.archives-ouvertes.fr/pasteur-01372632
Contributor : Isma Ziani <>
Submitted on : Tuesday, September 27, 2016 - 2:45:48 PM
Last modification on : Monday, January 13, 2020 - 5:08:07 PM

Links full text

Identifiers

Collections

Citation

Arnaud Moris, Anthony Pajot, Fabien Blanchet, Florence Guivel-Benhassine, Margarita Salcedo, et al.. Dendritic cells and HIV-specific CD4+ T cells: HIV antigen presentation, T-cell activation, and viral transfer.. Blood, American Society of Hematology, 2006, 108 (5), pp.1643-51. ⟨10.1182/blood-2006-02-006361⟩. ⟨pasteur-01372632⟩

Share

Metrics

Record views

187