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Journal articles
Dendritic cells and HIV-specific CD4+ T cells: HIV antigen presentation, T-cell activation, and viral transfer.
Abstract : Human immunodeficiency virus (HIV)-specific CD4+ lymphocytes are preferentially infected in HIV-positive individuals. To study this preferential infection, we have derived several HIV-specific (HS) CD4+ clones. We show that in dendritic cells (DCs), HIV virion capture led to major histocompatibility complex class-II (MHC-II)-restricted viral antigen presentation and to activation of HS cells. In contrast, neither cell-free virions nor infected lymphocytes activated HS cells. In DCs, the dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN/CD209), which internalizes virions, promoted MHC-II presentation of HIV antigens. Activation of HS cells by HIV-exposed DCs triggered an efficient viral spread in lymphocytes. CD4+ clones with irrelevant antigenic specificities were not activated by HIV-exposed DCs and poorly supported viral replication under this setting. Our results unravel the mechanisms of MHC-II-restricted HIV antigen presentation by DCs and describe how HIV gains access to the very cells designed by the immune system to counteract this pathogen.
https://hal-pasteur.archives-ouvertes.fr/pasteur-01372632
Contributor : Isma Ziani Connect in order to contact the contributor
Submitted on : Tuesday, September 27, 2016 - 2:45:48 PM
Last modification on : Tuesday, October 19, 2021 - 10:26:06 PM
Contributor : Isma Ziani Connect in order to contact the contributor
Submitted on : Tuesday, September 27, 2016 - 2:45:48 PM
Last modification on : Tuesday, October 19, 2021 - 10:26:06 PM