Actin’ on HIV: How Dendritic Cells Spread Infection

Daniel A. Donahue (1) , Olivier Schwartz (2, 1)

1 Virus et Immunité
2 VRI - Vaccine Research Institute [Créteil, France]

Dendritic cells (DCs) capture HIV particles and transmit them to CD4 T cells. In a recent article published in Cell, Ménager and Littman (2016) perform an shRNA screen in DCs and find that actin nucleation and stabilization regulate HIV uptake and maintain the virus on membrane protrusions for efficient transfer.

Domaines: Sciences du Vivant [q-bio]; Biologie cellulaire; Maladies infectieuses

Daniel A. Donahue, Olivier Schwartz. Actin’ on HIV: How Dendritic Cells Spread Infection. Cell Host and Microbe, 2016, 19 (3), pp.267 - 269. ⟨10.1016/j.chom.2016.02.016⟩. ⟨pasteur-01372388⟩