Microtubule dynamics and signal transduction at the immunological synapse: new partners and new connections.

Rémi Lasserre (1) , Andrès Alcover (1)

1 BIOCELLY - Biologie Cellulaire des Lymphocytes

Antigen recognition induces T cells to polarize towards antigen presenting cells (APC) generating an organized cell interface named the immunological synapse. T-cell microtubules (MTs) reorient the MT-organizing centre (MTOC) to the immunological synapse central region, while MT irradiate towards the synapse periphery. Martín-Cófreces et al (2012) describe in this issue that the MT plus-end-binding protein 1 (EB1) interacts with TCR cytosolic regions and mediate the organization of an immunological synapse fully functional to transduce activation signals.

Domains: Life Sciences [q-bio]; Immunology; Adaptive immunology; Life Sciences [q-bio]; Cellular Biology; Subcellular Processes [q-bio.SC]

Rémi Lasserre, Andrès Alcover. Microtubule dynamics and signal transduction at the immunological synapse: new partners and new connections.. EMBO Journal, 2012, 31 (21), pp.4100-2. ⟨10.1038/emboj.2012.276⟩. ⟨pasteur-01371060⟩