A. Calmette, La vaccination preventive contre la tuberculose. Paris: Masson et cie, 1927.

G. Mahairas, P. Sabo, M. Hickey, D. Singh, and C. Stover, Molecular analysis of genetic differences between Mycobacterium bovis BCG and virulent M. bovis., Journal of Bacteriology, vol.178, issue.5, pp.1274-1282, 1996.
DOI : 10.1128/jb.178.5.1274-1282.1996

S. Gordon, R. Brosch, A. Billault, T. Garnier, and K. Eiglmeier, Identification of variable regions in the genomes of tubercle bacilli using bacterial artificial chromosome arrays, Molecular Microbiology, vol.22, issue.3, pp.643-656, 1999.
DOI : 10.1073/pnas.94.18.9869

R. Brosch, S. Gordon, T. Garnier, K. Eiglmeier, and W. Frigui, Genome plasticity of BCG and impact on vaccine efficacy, Proceedings of the National Academy of Sciences, vol.104, issue.13, pp.5596-5601, 2007.
DOI : 10.1073/pnas.0700869104

P. Brodin, I. Rosenkrands, P. Andersen, S. Cole, and R. Brosch, ESAT-6 proteins: protective antigens and virulence factors?, Trends in Microbiology, vol.12, issue.11, pp.500-508, 2004.
DOI : 10.1016/j.tim.2004.09.007

W. Steenken, W. Oatway, and S. Petroff, BIOLOGICAL STUDIES OF THE TUBERCLE BACILLUS: III. DISSOCIATION AND PATHOGENICITY OF THE R AND S VARIANTS OF THE HUMAN TUBERCLE BACILLUS (H37), Journal of Experimental Medicine, vol.60, issue.4, pp.515-543, 1934.
DOI : 10.1084/jem.60.4.515

S. Cole, R. Brosch, J. Parkhill, T. Garnier, and C. Churcher, Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence, Nature, vol.25, issue.6685, pp.537-544, 1998.
DOI : 10.1038/31159

R. Brosch, W. Philipp, E. Stavropoulos, M. Colston, and S. Cole, Genomic analysis reveals variation between Mycobacterium tuberculosis H37Rv and the attenuated M. tuberculosis H37Ra strain, Infect Immun, vol.67, pp.5768-5774, 1999.

L. Pascopella, F. Collins, J. Martin, M. Lee, and G. Hatfull, Use of in vivo complementation in Mycobacterium tuberculosis to identify a genomic fragment associated with virulence, Infect Immun, vol.62, pp.1313-1319, 1994.

H. Salamon, M. Kato-maeda, P. Small, J. Drenkow, and T. Gingeras, Detection of Deleted Genomic DNA Using a Semiautomated Computational Analysis of GeneChip Data, Genome Research, vol.10, issue.12, pp.2044-2054, 2000.
DOI : 10.1101/gr.GR-1529R

S. Mostowy, C. Cleto, D. Sherman, and M. Behr, The Mycobacterium tuberculosis complex transcriptome of attenuation, Tuberculosis, vol.84, issue.3-4, pp.197-204, 2004.
DOI : 10.1016/j.tube.2004.02.002

Q. Gao, K. Kripke, Z. Arinc, M. Voskuil, and P. Small, Comparative expression studies of a complex phenotype: cord formation in Mycobacterium tuberculosis, Tuberculosis, vol.84, issue.3-4, pp.188-196, 2004.
DOI : 10.1016/j.tube.2003.12.013

U. Manjunatha, H. Boshoff, C. Dowd, L. Zhang, and T. Albert, Identification of a nitroimidazo-oxazine-specific protein involved in PA-824 resistance in Mycobacterium tuberculosis, Proceedings of the National Academy of Sciences, vol.103, issue.2, pp.431-436, 2006.
DOI : 10.1073/pnas.0508392103

E. Perez, S. Samper, Y. Bordas, C. Guilhot, and B. Gicquel, An essential role for phoP in Mycobacterium tuberculosis virulence, Molecular Microbiology, vol.182, issue.1, pp.179-187, 2001.
DOI : 10.1046/j.1365-2958.2001.02500.x

Y. Chen, W. Abdel-fattah, and F. Hulett, Residues Required for Bacillus subtilis PhoP DNA Binding or RNA Polymerase Interaction: Alanine Scanning of PhoP Effector Domain Transactivation Loop and ?? Helix 3, Journal of Bacteriology, vol.186, issue.5, pp.1493-1502, 2004.
DOI : 10.1128/JB.186.5.1493-1502.2004

C. Sassetti and E. Rubin, Genetic requirements for mycobacterial survival during infection, Proceedings of the National Academy of Sciences, vol.100, issue.22, pp.12989-12994, 2003.
DOI : 10.1073/pnas.2134250100

P. Bifani, S. Moghazeh, B. Shopsin, J. Driscoll, and A. Ravikovitch, Molecular characterization of Mycobacterium tuberculosis H37Rv/Ra variants: distinguishing the mycobacterial laboratory strain, J Clin Microbiol, vol.38, pp.3200-3204, 2000.

A. Pym, P. Brodin, R. Brosch, M. Huerre, and S. Cole, Loss of RD1 contributed to the attenuation of the live tuberculosis vaccines Mycobacterium bovis BCG and Mycobacterium microti, Molecular Microbiology, vol.232, issue.Suppl., pp.709-717, 2002.
DOI : 10.1046/j.1365-2958.2002.03237.x

F. Bange, F. Collins, W. Jacobs, and . Jr, Survival of mice infected with Mycobacterium smegmatis containing large DNA fragments from Mycobacterium tuberculosis, Tubercle and Lung Disease, vol.79, issue.3, pp.171-180, 1999.
DOI : 10.1054/tuld.1998.0201

S. Walters, E. Dubnau, I. Kolesnikova, F. Laval, and M. Daffe, The Mycobacterium tuberculosis PhoPR two-component system regulates genes essential for virulence and complex lipid biosynthesis, Molecular Microbiology, vol.178, issue.2, pp.312-330, 2006.
DOI : 10.1073/pnas.221272198

S. Gupta, A. Sinha, and D. Sarkar, PhoP involves recognition of novel direct repeat sequences in the regulatory region of the promoter, FEBS Letters, vol.185, issue.22, pp.5328-5338, 2006.
DOI : 10.1016/j.febslet.2006.09.004

L. Majlessi, P. Brodin, R. Brosch, M. Rojas, and H. Khun, Influence of ESAT-6 Secretion System 1 (RD1) of Mycobacterium tuberculosis on the Interaction between Mycobacteria and the Host Immune System, The Journal of Immunology, vol.174, issue.6, pp.3570-3579, 2005.
DOI : 10.4049/jimmunol.174.6.3570

P. Brodin, L. Majlessi, L. Marsollier, M. De-jonge, and D. Bottai, Dissection of ESAT-6 System 1 of Mycobacterium tuberculosis and Impact on Immunogenicity and Virulence, Infection and Immunity, vol.74, issue.1, pp.88-98, 2006.
DOI : 10.1128/IAI.74.1.88-98.2006

C. Martin, A. Williams, R. Hernandez-pando, P. Cardona, and E. Gormley, The live Mycobacterium tuberculosis phoP mutant strain is more attenuated than BCG and confers protective immunity against tuberculosis in mice and guinea pigs, Vaccine, vol.24, issue.17, pp.3408-3419, 2006.
DOI : 10.1016/j.vaccine.2006.03.017

A. Pym, P. Brodin, L. Majlessi, R. Brosch, and C. Demangel, Recombinant BCG exporting ESAT-6 confers enhanced protection against tuberculosis, Nature Medicine, vol.9, issue.5, pp.533-539, 2003.
DOI : 10.1038/nm859

S. Fortune, A. Jaeger, D. Sarracino, M. Chase, and C. Sassetti, Mutually dependent secretion of proteins required for mycobacterial virulence, Proceedings of the National Academy of Sciences, vol.102, issue.30, pp.10676-10681, 2005.
DOI : 10.1073/pnas.0504922102

M. Chesne-seck1, N. Barilone, F. Boudou, G. Asensio, J. Kolattukudy et al., A Point Mutation in the Two-Component Regulator PhoP-PhoR Accounts for the Absence of Polyketide-Derived Acyltrehaloses but Not That of Phthiocerol Dimycocerosates in Mycobacterium tuberculosis H37Ra, Journal of Bacteriology, vol.190, issue.4, 2008.
DOI : 10.1128/JB.01465-07

G. Middlebrook, R. Dubos, and C. Pierce, VIRULENCE AND MORPHOLOGICAL CHARACTERISTICS OF MAMMALIAN TUBERCLE BACILLI, Journal of Experimental Medicine, vol.86, issue.2, pp.175-184, 1947.
DOI : 10.1084/jem.86.2.175

D. Sharma and J. Tyagi, The value of comparative genomics in understanding mycobacterial virulence: Mycobacterium tuberculosis H37Ra genome sequencing ??? a worthwhile endeavour, Journal of Biosciences, vol.55, issue.2, pp.185-189, 2007.
DOI : 10.1007/s12038-007-0018-z

F. Hulett, The signal-transduction network for Pho regulation in Bacillus subtilis, Molecular Microbiology, vol.19, issue.5, pp.933-939, 1996.
DOI : 10.1046/j.1365-2958.1996.421953.x

E. Groisman, The Pleiotropic Two-Component Regulatory System PhoP-PhoQ, Journal of Bacteriology, vol.183, issue.6, pp.1835-1842, 2001.
DOI : 10.1128/JB.183.6.1835-1842.2001

J. Bijlsma and E. Groisman, The PhoP/PhoQ system controls the intramacrophage type three secretion system of Salmonella enterica, Molecular Microbiology, vol.102, issue.1, pp.85-96, 2005.
DOI : 10.1111/j.1365-2958.2005.04668.x

P. Ludwiczak, M. Gilleron, Y. Bordat, C. Martin, and B. Gicquel, Mycobacterium tuberculosis phoP mutant: lipoarabinomannan molecular structure, Microbiology, vol.148, issue.10, pp.3029-3037, 2002.
DOI : 10.1099/00221287-148-10-3029
URL : https://hal.archives-ouvertes.fr/hal-00177982

D. Schnappinger, S. Ehrt, M. Voskuil, Y. Liu, and J. Mangan, within Macrophages, The Journal of Experimental Medicine, vol.343, issue.5, pp.693-704, 2003.
DOI : 10.1046/j.1365-2958.2003.03313.x

K. Rohde, R. Abramovitch, and D. Russell, Mycobacterium tuberculosis Invasion of Macrophages: Linking Bacterial Gene Expression to Environmental Cues, Cell Host & Microbe, vol.2, issue.5, pp.352-364, 2007.
DOI : 10.1016/j.chom.2007.09.006

M. Blokpoel, H. Murphy, O. Toole, R. Wiles, S. Runn et al., Tetracycline-inducible gene regulation in mycobacteria, Nucleic Acids Research, vol.33, issue.2, p.22, 2005.
DOI : 10.1093/nar/gni023

M. Gutierrez, S. Brisse, R. Brosch, M. Fabre, and B. Omais, Ancient Origin and Gene Mosaicism of the Progenitor of Mycobacterium tuberculosis, PLoS Pathogens, vol.21, issue.1, 2005.
DOI : 10.1371/journal.ppat.0010005.st003
URL : https://hal.archives-ouvertes.fr/inserm-00080315

A. Sorensen, S. Nagai, G. Houen, P. Andersen, and A. Andersen, Purification and characterization of a low-molecular-mass T-cell antigen secreted by Mycobacterium tuberculosis, Infect Immun, vol.63, pp.1710-1717, 1995.

H. Volkman, H. Clay, D. Beery, J. Chang, and D. Sherman, Tuberculous Granuloma Formation Is Enhanced by a Mycobacterium Virulence Determinant, PLoS Biology, vol.79, issue.11, 2004.
DOI : 10.1371/journal.pbio.0020367.g010

M. De-jonge, G. Pehau-arnaudet, M. Fretz, F. Romain, and D. Bottai, ESAT-6 from Mycobacterium tuberculosis Dissociates from Its Putative Chaperone CFP-10 under Acidic Conditions and Exhibits Membrane-Lysing Activity, Journal of Bacteriology, vol.189, issue.16, pp.6028-6034, 2007.
DOI : 10.1128/JB.00469-07

R. Brosch, S. Gordon, M. Marmiesse, P. Brodin, and C. Buchrieser, complex, Proceedings of the National Academy of Sciences, vol.99, issue.6, pp.3684-3689, 2002.
DOI : 10.1073/pnas.052548299

P. Brodin, M. De-jonge, L. Majlessi, C. Leclerc, and M. Nilges, Functional Analysis of Early Secreted Antigenic Target-6, the Dominant T-cell Antigen of Mycobacterium tuberculosis, Reveals Key Residues Involved in Secretion, Complex Formation, Virulence, and Immunogenicity, Journal of Biological Chemistry, vol.280, issue.40, pp.33953-33959, 2005.
DOI : 10.1074/jbc.M503515200

L. Majlessi, M. Simsova, Z. Jarvis, P. Brodin, and M. Rojas, An Increase in Antimycobacterial Th1-Cell Responses by Prime-Boost Protocols of Immunization Does Not Enhance Protection against Tuberculosis, Infection and Immunity, vol.74, issue.4, pp.2128-2137, 2006.
DOI : 10.1128/IAI.74.4.2128-2137.2006