Skip to Main content Skip to Navigation
New interface
Journal articles

Reannotation of the genome sequence of Clostridium difficile strain 630.

Abstract : A regular update of genome annotations is a prerequisite step to help maintain the accuracy and relevance of the information they contain. Five years after the first publication of the complete genome sequence of Clostridium difficile strain 630, we manually reannotated each of the coding sequences (CDSs), using a high-level annotation platform. The functions of more than 500 genes annotated previously with putative functions were reannotated based on updated sequence similarities to proteins whose functions have been recently identified by experimental data from the literature. We also modified 222 CDS starts, detected 127 new CDSs and added the enzyme commission numbers, which were not supplied in the original annotation. In addition, an intensive project was undertaken to standardize the names of genes and gene products and thus harmonize as much as possible with the HAMAP project. The reannotation is stored in a relational database that will be available on the MicroScope web-based platform ( The original submission stored in the (International Nucleotide Sequence Database Collaboration) INSDC nucleotide sequence databases was also updated.
Complete list of metadata

Cited literature [16 references]  Display  Hide  Download
Contributor : Marc Monot Connect in order to contact the contributor
Submitted on : Friday, September 23, 2016 - 1:30:22 PM
Last modification on : Tuesday, September 6, 2022 - 3:39:58 AM


Files produced by the author(s)


Distributed under a Creative Commons Attribution - NonCommercial - NoDerivatives 4.0 International License



Marc Monot, Caroline Boursaux-Eude, Marie Thibonnier, David Vallenet, Ivan Moszer, et al.. Reannotation of the genome sequence of Clostridium difficile strain 630.. Journal of Medical Microbiology, 2011, 60 (8), pp.1193-9. ⟨10.1099/jmm.0.030452-0⟩. ⟨pasteur-01370838⟩



Record views


Files downloads