Multidisciplinary analysis of a nontoxigenic Clostridium difficile strain with stable resistance to metronidazole. - Institut Pasteur Accéder directement au contenu
Article Dans Une Revue Antimicrobial Agents and Chemotherapy Année : 2014

Multidisciplinary analysis of a nontoxigenic Clostridium difficile strain with stable resistance to metronidazole.

Résumé

Stable resistance to metronidazole in a nontoxigenic Clostridium difficile strain was investigated at both the genomic and proteomic levels. Alterations in the metabolic pathway involving the pyruvate-ferredoxin oxidoreductase were found, suggesting that reduction of metronidazole, required for its activity, may be less efficient in this strain. Proteomic studies also showed a cellular response to oxidative stress.

Dates et versions

pasteur-01370760 , version 1 (23-09-2016)

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Citer

Ines Moura, Marc Monot, Chiara Tani, Patrizia Spigaglia, Fabrizio Barbanti, et al.. Multidisciplinary analysis of a nontoxigenic Clostridium difficile strain with stable resistance to metronidazole.. Antimicrobial Agents and Chemotherapy, 2014, 58 (8), pp.4957-60. ⟨10.1128/AAC.02350-14⟩. ⟨pasteur-01370760⟩
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