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Multidisciplinary analysis of a nontoxigenic Clostridium difficile strain with stable resistance to metronidazole.

Abstract : Stable resistance to metronidazole in a nontoxigenic Clostridium difficile strain was investigated at both the genomic and proteomic levels. Alterations in the metabolic pathway involving the pyruvate-ferredoxin oxidoreductase were found, suggesting that reduction of metronidazole, required for its activity, may be less efficient in this strain. Proteomic studies also showed a cellular response to oxidative stress.
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Submitted on : Friday, September 23, 2016 - 12:19:25 PM
Last modification on : Wednesday, June 24, 2020 - 3:02:06 PM

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Ines Moura, Marc Monot, Chiara Tani, Patrizia Spigaglia, Fabrizio Barbanti, et al.. Multidisciplinary analysis of a nontoxigenic Clostridium difficile strain with stable resistance to metronidazole.. Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2014, 58 (8), pp.4957-60. ⟨10.1128/AAC.02350-14⟩. ⟨pasteur-01370760⟩

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