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Journal articles
Multidisciplinary analysis of a nontoxigenic Clostridium difficile strain with stable resistance to metronidazole.
Ines Moura
1
Marc Monot
2
Chiara Tani
3
Patrizia Spigaglia
1
Fabrizio Barbanti
1
Nathalie Norais
3
Bruno Dupuy
2
Emilio Bouza
4
Paola Mastrantonio
1
Ines Moura 1
Author
Marc Monot 2
Author IdHAL : marcmonot ORCID : https://orcid.org/0000-0003-0738-7335
Chiara Tani 3
Author
Patrizia Spigaglia 1
Author
Fabrizio Barbanti 1
Author
Nathalie Norais 3
Author
Bruno Dupuy 2
Author IdHAL : bruno-dupuy
Emilio Bouza 4
Author
Paola Mastrantonio 1
Author
2
PBA (U-Pasteur_6) - Pathogénèse des Bactéries Anaérobies / Pathogenesis of Bacterial Anaerobes (Département Microbiologie - 25-28 rue du Docteur Roux, 75724 Paris Cedex 15 - France)
- Institut Pasteur [Paris] (25-28, rue du docteur Roux, 75724 Paris cedex 15 - France)
- UPD7 - Université Paris Diderot - Paris 7 : U-Pasteur_6 (5 rue Thomas-Mann - 75205 Paris cedex 13 - France)
3
Structural Mass Spectrometry and Proteomics Unit [Italy] (Siena - Italy)
- Novartis Vaccines and Diagnostics [Siena] (Siena - Italy)
4
Hospital General Universitario "Gregorio Marañón" [Madrid] (Dr Esquerdo 46, 28007 Madrid - Spain)
Abstract : Stable resistance to metronidazole in a nontoxigenic Clostridium difficile strain was investigated at both the genomic and proteomic levels. Alterations in the metabolic pathway involving the pyruvate-ferredoxin oxidoreductase were found, suggesting that reduction of metronidazole, required for its activity, may be less efficient in this strain. Proteomic studies also showed a cellular response to oxidative stress.
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Journal articles
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https://hal-pasteur.archives-ouvertes.fr/pasteur-01370760
Contributor : Marc Monot <>
Submitted on : Friday, September 23, 2016 - 12:19:25 PM
Last modification on : Friday, June 11, 2021 - 10:36:05 AM
Contributor : Marc Monot <>
Submitted on : Friday, September 23, 2016 - 12:19:25 PM
Last modification on : Friday, June 11, 2021 - 10:36:05 AM
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Identifiers
- HAL Id : pasteur-01370760, version 1
- DOI : 10.1128/AAC.02350-14
- PUBMED : 24913157
- PUBMEDCENTRAL : PMC4135993
Collections
PASTEUR | UNIV-PARIS7 | USPC | UNIV-PARIS | UP-SCIENCES
Citation
Ines Moura, Marc Monot, Chiara Tani, Patrizia Spigaglia, Fabrizio Barbanti, et al.. Multidisciplinary analysis of a nontoxigenic Clostridium difficile strain with stable resistance to metronidazole.. Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2014, 58 (8), pp.4957-60. ⟨10.1128/AAC.02350-14⟩. ⟨pasteur-01370760⟩
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