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Multidisciplinary analysis of a nontoxigenic Clostridium difficile strain with stable resistance to metronidazole.

Ines Moura 1 Marc Monot 2 Chiara Tani 3 Patrizia Spigaglia 1 Fabrizio Barbanti 1 Nathalie Norais 3 Bruno Dupuy 2 Emilio Bouza 4 Paola Mastrantonio 1
1 Departmet of Infectious, Parasitic and Immune-Mediated Disease
2 PBA (U-Pasteur_6) - Pathogénèse des Bactéries Anaérobies / Pathogenesis of Bacterial Anaerobes
3 Structural Mass Spectrometry and Proteomics Unit [Italy]
4 Hospital General Universitario "Gregorio Marañón" [Madrid]
Abstract : Stable resistance to metronidazole in a nontoxigenic Clostridium difficile strain was investigated at both the genomic and proteomic levels. Alterations in the metabolic pathway involving the pyruvate-ferredoxin oxidoreductase were found, suggesting that reduction of metronidazole, required for its activity, may be less efficient in this strain. Proteomic studies also showed a cellular response to oxidative stress.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-01370760
Contributor : Marc Monot <>
Submitted on : Friday, September 23, 2016 - 12:19:25 PM
Last modification on : Wednesday, June 24, 2020 - 3:02:06 PM

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PASTEUR | UNIV-PARIS7 | USPC | UNIV-PARIS | UP-SCIENCES

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Ines Moura, Marc Monot, Chiara Tani, Patrizia Spigaglia, Fabrizio Barbanti, et al.. Multidisciplinary analysis of a nontoxigenic Clostridium difficile strain with stable resistance to metronidazole.. Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2014, 58 (8), pp.4957-60. ⟨10.1128/AAC.02350-14⟩. ⟨pasteur-01370760⟩

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