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Journal articles
Biofilm-Related Infections: Bridging the Gap between Clinical Management and Fundamental Aspects of Recalcitrance toward Antibiotics
Abstract : Surface-associated microbial communities, called biofilms, are present in all environments. Although biofilms play an important positive role in a variety of ecosystems, they also have many negative effects, including biofilm-related infections in medical settings. The ability of pathogenic biofilms to survive in the presence of high concentrations of antibiotics is called "recalcitrance" and is a characteristic property of the biofilm lifestyle, leading to treatment failure and infection recurrence. This review presents our current understanding of the molecular mechanisms of biofilm recalcitrance toward antibiotics and describes how recent progress has improved our capacity to design original and efficient strategies to prevent or eradicate biofilm-related infections.
https://hal-pasteur.archives-ouvertes.fr/pasteur-01370744
Contributor : Pascale Sitbon <>
Submitted on : Friday, September 23, 2016 - 11:58:11 AM
Last modification on : Thursday, May 27, 2021 - 5:08:03 PM
Contributor : Pascale Sitbon <>
Submitted on : Friday, September 23, 2016 - 11:58:11 AM
Last modification on : Thursday, May 27, 2021 - 5:08:03 PM
File
89-mmbr 2014-Lebeaux.pdf
Publication funded by an institution