P. Shih, D. Wu, A. Latifi, S. Axen, D. Fewer et al., Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing, Proceedings of the National Academy of Sciences, vol.110, issue.3, pp.1053-1058
DOI : 10.1073/pnas.1217107110
URL : https://hal.archives-ouvertes.fr/pasteur-01389305

R. Buick, The antiquity of oxygenic photosynthesis: evidence from stromatolites in sulphate-deficient Archaean lakes, Science, vol.255, issue.5040, pp.74-77, 1992.
DOI : 10.1126/science.11536492

E. Dittmann, D. Fewer, and B. Neilan, Cyanobacterial toxins: biosynthetic routes and evolutionary roots, FEMS Microbiology Reviews, vol.37, issue.1, pp.23-43, 2013.
DOI : 10.1111/j.1574-6976.2012.12000.x

M. Namikoshi and K. Rinehart, Bioactive compounds produced by cyanobacteria, Journal of Industrial Microbiology & Biotechnology, vol.116, issue.5-6, pp.373-384, 1996.
DOI : 10.1007/BF01574768

A. Burja, B. Banaigs, E. Abou-mansour, J. Burgess, and P. Wright, Marine cyanobacteria???a prolific source of natural products, Tetrahedron, vol.57, issue.46, pp.9347-9377, 2001.
DOI : 10.1016/S0040-4020(01)00931-0

M. Welker and H. Von-döhren, Cyanobacterial peptides ??? Nature's own combinatorial biosynthesis, FEMS Microbiology Reviews, vol.30, issue.4, pp.530-563, 2006.
DOI : 10.1111/j.1574-6976.2006.00022.x

T. Mihali, R. Kellmann, J. Muenchhoff, K. Barrow, and B. Neilan, Characterization of the Gene Cluster Responsible for Cylindrospermopsin Biosynthesis, Applied and Environmental Microbiology, vol.74, issue.3, pp.716-722, 2008.
DOI : 10.1128/AEM.01988-07

A. Mejean, S. Mann, T. Maldiney, G. Vassiliadis, O. Lequin et al., -Proline, Journal of the American Chemical Society, vol.131, issue.22, pp.7512-7513, 2009.
DOI : 10.1021/ja9024353
URL : https://hal.archives-ouvertes.fr/tel-00011589

D. Tillett, E. Dittmann, M. Erhard, H. Von-döhren, T. Börner et al., Structural organization of microcystin biosynthesis in Microcystis aeruginosa PCC7806: an integrated peptide???polyketide synthetase system, Chemistry & Biology, vol.7, issue.10, pp.753-764, 2000.
DOI : 10.1016/S1074-5521(00)00021-1

R. Kellmann, T. Mihali, Y. Jeon, R. Pickford, F. Pomati et al., Biosynthetic Intermediate Analysis and Functional Homology Reveal a Saxitoxin Gene Cluster in Cyanobacteria, Applied and Environmental Microbiology, vol.74, issue.13, pp.4044-4053, 2008.
DOI : 10.1128/AEM.00353-08

D. Edwards, B. Marquez, L. Nogle, K. Mcphail, D. Goeger et al., Structure and Biosynthesis of the Jamaicamides, New Mixed Polyketide-Peptide Neurotoxins from the Marine Cyanobacterium Lyngbya majuscula, Chemistry & Biology, vol.11, issue.6, pp.817-833, 2004.
DOI : 10.1016/j.chembiol.2004.03.030

A. Jones, E. Monroe, S. Podell, W. Hess, S. Klages et al., Genomic insights into the physiology and ecology of the marine filamentous cyanobacterium Lyngbya majuscula, Proceedings of the National Academy of Sciences, vol.108, issue.21, pp.8815-8820, 2011.
DOI : 10.1073/pnas.1101137108

L. Gu, B. Wang, A. Kulkarni, T. Geders, R. Grindberg et al., Metamorphic enzyme assembly in polyketide diversification, Nature, vol.130, issue.7247, pp.731-735, 2009.
DOI : 10.1038/nature07870

A. Rantala, D. Fewer, M. Hisbergues, L. Rouhiainen, J. Vaitomaa et al., Phylogenetic evidence for the early evolution of microcystin synthesis, Proceedings of the National Academy of Sciences, vol.101, issue.2, pp.568-573, 2004.
DOI : 10.1073/pnas.0304489101

A. Moustafa, J. Loram, J. Hackett, D. Anderson, F. Plumley et al., Origin of Saxitoxin Biosynthetic Genes in Cyanobacteria, PLoS ONE, vol.8, issue.6, p.578, 2009.
DOI : 10.1371/journal.pone.0005758.s001

A. Ginolhac, C. Jarrin, P. Robe, G. Perriere, T. Vogel et al., Type I Polyketide Synthases May Have Evolved Through Horizontal Gene Transfer, Journal of Molecular Evolution, vol.298, issue.6, pp.716-725, 2005.
DOI : 10.1007/s00239-004-0161-1
URL : https://hal.archives-ouvertes.fr/halsde-00354210

H. Jenke-kodama, A. Sandmann, R. Müller, and E. Dittmann, Evolutionary Implications of Bacterial Polyketide Synthases, Molecular Biology and Evolution, vol.22, issue.10, pp.2027-2039, 2005.
DOI : 10.1093/molbev/msi193

H. Jenke-kodama, T. Börner, and E. Dittmann, Natural Biocombinatorics in the Polyketide Synthase Genes of the Actinobacterium Streptomyces avermitilis, PLoS Computational Biology, vol.11, issue.10, p.132, 2006.
DOI : 10.1371/journal.pcbi.0020132.st001

M. Fischbach, C. Walsh, and J. Clardy, The evolution of gene collectives: How natural selection drives chemical innovation, Proceedings of the National Academy of Sciences, vol.105, issue.12, pp.4601-4608, 2008.
DOI : 10.1073/pnas.0709132105

C. Hertweck, The Biosynthetic Logic of Polyketide Diversity, Angewandte Chemie International Edition, vol.45, issue.26, pp.4688-4716, 2009.
DOI : 10.1002/anie.200806121

E. Balskus and C. Walsh, The Genetic and Molecular Basis for Sunscreen Biosynthesis in Cyanobacteria, Science, vol.329, issue.5999, pp.1653-1656, 2010.
DOI : 10.1126/science.1193637

M. Marahiel and L. Essen, Chapter 13 Nonribosomal Peptide Synthetases, Method Enzymol, vol.458, pp.337-351, 2009.
DOI : 10.1016/S0076-6879(09)04813-7

L. Rouhiainen, J. Jokela, D. Fewer, M. Urmann, and K. Sivonen, Two Alternative Starter Modules for the Non-Ribosomal Biosynthesis of Specific Anabaenopeptin Variants in Anabaena (Cyanobacteria), Chemistry & Biology, vol.17, issue.3, pp.265-273, 2010.
DOI : 10.1016/j.chembiol.2010.01.017

K. Rinehart, K. Harada, M. Namikoshi, C. Chen, C. Harvis et al., Nodularin, microcystin, and the configuration of Adda, Journal of the American Chemical Society, vol.110, issue.25, pp.8557-8558, 1988.
DOI : 10.1021/ja00233a049

A. Rantala-ylinen, S. Kana, H. Wang, L. Rouhiainen, M. Wahlsten et al., Anatoxin-a Synthetase Gene Cluster of the Cyanobacterium Anabaena sp. Strain 37 and Molecular Methods To Detect Potential Producers, Applied and Environmental Microbiology, vol.77, issue.20, pp.7271-7278, 2011.
DOI : 10.1128/AEM.06022-11

R. Araoz, H. Nghiem, R. Rippka, N. Palibroda, N. Tandeau-de-marsac et al., Neurotoxins in axenic oscillatorian cyanobacteria: coexistence of anatoxin-a and homoanatoxin-a determined by ligand-binding assay and GC/MS, Microbiology, vol.151, issue.4, pp.1263-1273, 2005.
DOI : 10.1099/mic.0.27660-0

M. Laport, O. Santos, and G. Muricy, Marine Sponges: Potential Sources of New Antimicrobial Drugs, Current Pharmaceutical Biotechnology, vol.10, issue.1, pp.86-105, 2009.
DOI : 10.2174/138920109787048625

A. Letzel, S. Pidot, and C. Hertweck, A genomic approach to the cryptic secondary metabolome of the anaerobic world, Nat. Prod. Rep., vol.63, issue.2, pp.377-476, 2013.
DOI : 10.1128/mBio.00025-12

Q. Fan, G. Huang, S. Lechno-yossef, C. Wolk, T. Kaneko et al., Clustered genes required for synthesis and deposition of envelope glycolipids in Anabaena sp. strain PCC 7120, Molecular Microbiology, vol.180, issue.1, pp.227-243, 2005.
DOI : 10.1111/j.1365-2958.2005.04818.x

K. Kumar, R. Mella-herrera, and J. Golden, Cyanobacterial Heterocysts, Cold Spring Harbor Perspectives in Biology, vol.2, issue.4, p.315, 2009.
DOI : 10.1101/cshperspect.a000315

C. Shulse and E. Allen, Widespread Occurrence of Secondary Lipid Biosynthesis Potential in Microbial Lineages, PLoS ONE, vol.45, issue.5, p.20146, 2011.
DOI : 10.1371/journal.pone.0020146.s006

S. Goldman, P. Lammers, M. Berman, and J. Sanders-loehr, Siderophore-mediated iron uptake in different strains of Anabaena sp, J Bacteriol, vol.156, pp.1144-1150, 1983.

H. Beiderbeck, K. Taraz, H. Budzikiewicz, and A. Walsby, Abstract, Zeitschrift f??r Naturforschung C, vol.55, issue.9-10, pp.681-687, 2000.
DOI : 10.1515/znc-2000-9-1002

Y. Itou, S. Okada, and M. Murakami, Two structural isomeric siderophores from the freshwater cyanobacterium Anabaena cylindrica (NIES-19)

Y. Ito, K. Ishida, S. Okada, and M. Murakami, The absolute stereochemistry of anachelins, siderophores from the cyanobacterium Anabaena cylindrica, Tetrahedron, vol.60, issue.41, pp.9075-9080, 2004.
DOI : 10.1016/j.tet.2004.07.105

R. Jeanjean, E. Talla, A. Latifi, M. Havaux, A. Janicki et al., A large gene cluster encoding peptide synthetases and polyketide synthases is involved in production of siderophores and oxidative stress response in the cyanobacterium Anabaena sp. strain PCC 7120, Environmental Microbiology, vol.409, issue.10, pp.2574-2585, 2008.
DOI : 10.1111/j.1462-2920.2008.01680.x

M. Rondon, K. Ballering, and M. Thomas, Identification and analysis of a siderophore biosynthetic gene cluster from Agrobacterium tumefaciens C58, Microbiology, vol.150, issue.11, pp.3857-3866, 2004.
DOI : 10.1099/mic.0.27319-0

A. Jones, E. Monroe, E. Eisman, L. Gerwick, D. Sherman et al., The unique mechanistic transformations involved in the biosynthesis of modular natural products from marine cyanobacteria, Natural Product Reports, vol.24, issue.7, pp.1048-1065, 2010.
DOI : 10.1039/c000535e

J. Humbert, V. Barbe, A. Latifi, M. Gugger, A. Calteau et al., A Tribute to Disorder in the Genome of the Bloom-Forming Freshwater Cyanobacterium Microcystis aeruginosa, PLoS ONE, vol.25, issue.8, p.70747, 2013.
DOI : 10.1371/journal.pone.0070747.s009
URL : https://hal.archives-ouvertes.fr/bioemco-00851371

H. Sogge, T. Rohrlack, T. Rounge, J. Sonstebo, A. Tooming-klunderud et al., Gene Flow, Recombination, and Selection in Cyanobacteria: Population Structure of Geographically Related Planktothrix Freshwater Strains, Applied and Environmental Microbiology, vol.79, issue.2, pp.508-515, 2013.
DOI : 10.1128/AEM.02417-12

N. Ziemert, A. Lechner, M. Wietz, N. Millan-aguinaga, K. Chavarria et al., Diversity and evolution of secondary metabolism in the marine actinomycete genus Salinispora, Proceedings of the National Academy of Sciences, vol.111, issue.12, pp.1130-1139
DOI : 10.1073/pnas.1324161111

A. Dufresne, M. Ostrowski, D. Scanlan, L. Garczarek, S. Mazard et al., Unraveling the genomic mosaic of a ubiquitous genus of marine cyanobacteria, Genome Biol, vol.915, p.90977, 2008.
URL : https://hal.archives-ouvertes.fr/hal-00338634

G. Szöllosi, B. Boussau, S. Abby, E. Tannier, and V. Daubin, Phylogenetic modeling of lateral gene transfer reconstructs the pattern and relative timing of speciations, Proceedings of the National Academy of Sciences, vol.109, issue.43, pp.17513-17518
DOI : 10.1073/pnas.1202997109

K. Penn, J. Wang, S. Fernando, and J. Thompson, Secondary metabolite gene expression and interplay of bacterial functions in a tropical freshwater cyanobacterial bloom, The ISME Journal, vol.6, issue.9, pp.1866-1878, 2014.
DOI : 10.1038/ismej.2014.27

D. Hutchins, A. Witter, A. Butler, G. Luther, and . Iii, Competition among marine phytoplankton for different chelated iron species, Nature, vol.400, issue.6747, pp.858-861, 1999.
DOI : 10.1038/23680

A. Kampa, A. Gagunashvili, T. Gulder, B. Morikana, C. Daolio et al., Metagenomic natural product discovery in lichen provides evidence for a family of biosynthetic pathways in diverse symbioses, Proceedings of the National Academy of Sciences, vol.110, issue.33, pp.3129-3137
DOI : 10.1073/pnas.1305867110

N. Leikoski, L. Liu, J. Jokela, M. Wahlsten, M. Gugger et al., Genome Mining Expands the Chemical Diversity of the Cyanobactin Family to Include Highly Modified Linear Peptides, Chemistry & Biology, vol.20, issue.8, pp.1033-1043, 2013.
DOI : 10.1016/j.chembiol.2013.06.015
URL : https://hal.archives-ouvertes.fr/pasteur-01388247

W. Tang and W. Van-der-donk, Structural Characterization of Four Prochlorosins: A Novel Class of Lantipeptides Produced by Planktonic Marine Cyanobacteria, Biochemistry, vol.51, issue.21, pp.4271-4279, 2012.
DOI : 10.1021/bi300255s

M. Donia, J. Ravel, and E. Schmidt, A global assembly line for cyanobactins, Nature Chemical Biology, vol.74, issue.6, pp.341-343, 2008.
DOI : 10.1038/nchembio.84

P. Jensen, K. Chavarria, W. Fenical, B. Moore, and N. Ziemert, Challenges and triumphs to genomics-based natural product discovery, Journal of Industrial Microbiology & Biotechnology, vol.7, issue.2, pp.203-209, 2014.
DOI : 10.1007/s10295-013-1353-8

J. Watrous, P. Roach, T. Alexandrov, B. Heath, J. Yang et al., Mass spectral molecular networking of living microbial colonies, Proceedings of the National Academy of Sciences, vol.109, issue.26, pp.1743-1752
DOI : 10.1073/pnas.1203689109

D. Nguyen, C. Wu, W. Moree, A. Lamsa, M. Medema et al., MS/MS networking guided analysis of molecule and gene cluster families, Proceedings of the National Academy of Sciences, vol.110, issue.28, pp.2611-2620
DOI : 10.1073/pnas.1303471110

D. Vallenet, E. Belda, A. Calteau, S. Cruveiller, S. Engelen et al., MicroScope--an integrated microbial resource for the curation and comparative analysis of genomic and metabolic data, Nucleic Acids Research, vol.41, issue.D1, pp.636-647, 2013.
DOI : 10.1093/nar/gks1194

B. Bachmann and J. Ravel, Chapter 8 Methods for In Silico Prediction of Microbial Polyketide and Nonribosomal Peptide Biosynthetic Pathways from DNA Sequence Data, Method Enzymol, vol.458, pp.181-217, 2009.
DOI : 10.1016/S0076-6879(09)04808-3

M. Medema, K. Blin, P. Cimermancic, V. De-jager, P. Zakrzewski et al., antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences, Nucleic Acids Research, vol.39, issue.suppl, pp.339-346, 2011.
DOI : 10.1093/nar/gkr466

N. Ziemert, S. Podell, K. Penn, J. Badger, E. Allen et al., The Natural Product Domain Seeker NaPDoS: A Phylogeny Based Bioinformatic Tool to Classify Secondary Metabolite Gene Diversity, PLoS ONE, vol.2, issue.3, p.34064, 2012.
DOI : 10.1371/journal.pone.0034064.s007

M. Röttig, M. Medema, K. Blin, T. Weber, C. Rausch et al., NRPSpredictor2--a web server for predicting NRPS adenylation domain specificity, Nucleic Acids Research, vol.39, issue.suppl, pp.362-367, 2011.
DOI : 10.1093/nar/gkr323

A. Marchler-bauer and S. Bryant, CD-Search: protein domain annotations on the fly, Nucleic Acids Research, vol.32, issue.Web Server, pp.327-331, 2004.
DOI : 10.1093/nar/gkh454

S. Altschul, T. Madden, A. Schäffer, J. Zhang, Z. Zhang et al., Gapped BLAST and PSI-BLAST: a new generation of protein database search programs, Nucleic Acids Research, vol.25, issue.17, pp.3389-3402, 1997.
DOI : 10.1093/nar/25.17.3389

N. Mulder and R. Apweiler, InterPro and InterProScan: Tools for Protein Sequence Classification and Comparison, Methods Mol Biol, vol.369, pp.59-70, 2007.
DOI : 10.1385/1-59745-515-6:59

M. Wu and J. Eisen, A simple, fast, and accurate method of phylogenomic inference, Genome Biology, vol.9, issue.10, p.151, 2008.
DOI : 10.1186/gb-2008-9-10-r151

K. Katoh, K. Kuma, H. Toh, and T. Miyata, MAFFT version 5: improvement in accuracy of multiple sequence alignment, Nucleic Acids Research, vol.33, issue.2, pp.511-518, 2005.
DOI : 10.1093/nar/gki198

A. Criscuolo and S. Gribaldo, BMGE (Block Mapping and Gathering with Entropy): a new software for selection of phylogenetic informative regions from multiple sequence alignments, BMC Evolutionary Biology, vol.10, issue.1, p.201, 2010.
DOI : 10.1186/1471-2148-10-210

S. Guindon, J. Dufayard, V. Lefort, M. Anisimova, W. Hordijk et al., New Algorithms and Methods to Estimate Maximum-Likelihood Phylogenies: Assessing the Performance of PhyML 3.0, Systematic Biology, vol.59, issue.3, pp.307-321, 2010.
DOI : 10.1093/sysbio/syq010
URL : https://hal.archives-ouvertes.fr/lirmm-00511784