Emergence of epidemic Neisseria meningitidis serogroup C in Niger, 2015: an analysis of national surveillance data. - Archive ouverte HAL Access content directly
Journal Articles The Lancet Infectious Diseases Year : 2016

Emergence of epidemic Neisseria meningitidis serogroup C in Niger, 2015: an analysis of national surveillance data.

(1) , (2) , (2) , (3) , (1) , (4) , (5) , (3) , , (6) , (1) , (1) , (1) , (4) , (7) , (7) , (3) , (8) , (1) , (4) , (2) , (9) , (3) , (1) , (3)
1
2
3
4
5
6
7
8
9
Flavien Ake
  • Function : Author
Muhamed-Kheir Taha

Abstract

To combat Neisseria meningitidis serogroup A epidemics in the meningitis belt of sub-Saharan Africa, a meningococcal serogroup A conjugate vaccine (MACV) has been progressively rolled out since 2010. We report the first meningitis epidemic in Niger since the nationwide introduction of MACV. We compiled and analysed nationwide case-based meningitis surveillance data in Niger. Cases were confirmed by culture or direct real-time PCR, or both, of cerebrospinal fluid specimens, and whole-genome sequencing was used to characterise isolates. Information on vaccination campaigns was collected by the Niger Ministry of Health and WHO. From Jan 1 to June 30, 2015, 9367 suspected meningitis cases and 549 deaths were reported in Niger. Among 4301 cerebrospinal fluid specimens tested, 1603 (37·3%) were positive for a bacterial pathogen, including 1147 (71·5%) that were positive for N meningitidis serogroup C (NmC). Whole-genome sequencing of 77 NmC isolates revealed the strain to be ST-10217. Although vaccination campaigns were limited in scope because of a global vaccine shortage, 1·4 million people were vaccinated from March to June, 2015. This epidemic represents the largest global NmC outbreak so far and shows the continued threat of N meningitidis in sub-Saharan Africa. The risk of further regional expansion of this novel clone highlights the need for continued strengthening of case-based surveillance. The availability of an affordable, multivalent conjugate vaccine may be important in future epidemic response. MenAfriNet consortium, a partnership between the US Centers for Disease Control and Prevention, WHO, and Agence de Médecine Preventive, through a grant from the Bill & Melinda Gates Foundation.

Dates and versions

pasteur-01357718 , version 1 (30-08-2016)

Identifiers

Cite

Fati Sidikou, Maman Zaneidou, Ibrahim Alkassoum, Stephanie Schwartz, Bassira Issaka, et al.. Emergence of epidemic Neisseria meningitidis serogroup C in Niger, 2015: an analysis of national surveillance data.. The Lancet Infectious Diseases, 2016, ⟨10.1016/S1473-3099(16)30253-5⟩. ⟨pasteur-01357718⟩
98 View
0 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More