Skip to Main content Skip to Navigation
Journal articles

Legionella pneumophila type IV effectors hijack the transcription and translation machinery of the host cell.

Abstract : Intracellular bacterial pathogens modulate the host response to persist and replicate inside a eukaryotic cell and cause disease. Legionella pneumophila, the causative agent of Legionnaires' disease, is present in freshwater environments and represents one of these pathogens. During coevolution with protozoan cells, L. pneumophila has acquired highly sophisticated and diverse strategies to hijack host cell processes. It secretes hundreds of effectors into the host cell, and these manipulate host signaling pathways and key cellular processes. Recently it has been shown that L. pneumophila is also able to alter the transcription and translation machinery of the host and to exploit epigenetic mechanisms in the cells it resides in to counteract host responses.
Document type :
Journal articles
Complete list of metadatas

Cited literature [66 references]  Display  Hide  Download

https://hal-pasteur.archives-ouvertes.fr/pasteur-01328872
Contributor : Isabelle Hoffmann <>
Submitted on : Friday, June 26, 2020 - 5:00:08 PM
Last modification on : Wednesday, July 22, 2020 - 11:38:10 AM

File

2014 Trends Cell Biol_Rolando....
Files produced by the author(s)

Identifiers

Collections

Citation

Monica Rolando, Carmen Buchrieser. Legionella pneumophila type IV effectors hijack the transcription and translation machinery of the host cell.. Trends in Cell Biology, Elsevier, 2014, 24 (12), pp.771-8. ⟨10.1016/j.tcb.2014.06.002⟩. ⟨pasteur-01328872⟩

Share

Metrics

Record views

166

Files downloads

114