P. Aisen, The binding and release of iron by transferrin, Birth Defects Orig Artic Ser, vol.12, pp.81-95, 1976.

K. Allard, V. Viswanathan, and N. Cianciotto, lbtA and lbtB Are Required for Production of the Legionella pneumophila Siderophore Legiobactin, Journal of Bacteriology, vol.188, issue.4, pp.1351-1363, 2006.
DOI : 10.1128/JB.188.4.1351-1363.2006

K. Allard, J. Dao, P. Sanjeevaiah, K. Mccoy-simandle, C. Chatfield et al., Purification of Legiobactin and Importance of This Siderophore in Lung Infection by Legionella pneumophila, Infection and Immunity, vol.77, issue.7, pp.2887-2895, 2009.
DOI : 10.1128/IAI.00087-09

S. Andrews, Making DNA without iron - induction of a manganese-dependent ribonucleotide reductase in response to iron starvation, Molecular Microbiology, vol.46, issue.2, pp.286-289, 2011.
DOI : 10.1111/j.1365-2958.2011.07594.x

S. Andrews, A. Robinson, and F. Rodriguez-quinones, Bacterial iron homeostasis, FEMS Microbiology Reviews, vol.27, issue.2-3, pp.215-237, 2003.
DOI : 10.1016/S0168-6445(03)00055-X

P. Borella, M. Montagna, V. Romano-spica, S. Stampi, G. Stancanelli et al., Infection Risk from Domestic Hot Water, Emerging Infectious Diseases, vol.10, issue.3, pp.457-464, 2004.
DOI : 10.3201/eid1003.020707

A. Hagman, M. Jules, O. Sismeiro, M. Dillies, and C. Gouyette, Virulence strategies for infecting phagocytes deduced from the in vivo transcriptional program of Legionella pneumophila, Cell Microbiol, vol.8, pp.1228-1240, 2006.

B. Byrne and M. Swanson, Expression of Legionella pneumophila virulence traits in response to growth conditions, Infect Immun, vol.66, pp.3029-3034, 1998.

C. Cazalet, C. Rusniok, H. Bruggemann, N. Zidane, A. Magnier et al., Evidence in the Legionella pneumophila genome for exploitation of host cell functions and high genome plasticity, Nature Genetics, vol.67, issue.11, pp.1165-1173, 2004.
DOI : 10.1093/bioinformatics/btg490

C. Chatfield and N. Cianciotto, The Secreted Pyomelanin Pigment of Legionella pneumophila Confers Ferric Reductase Activity, Infection and Immunity, vol.75, issue.8, pp.4062-4070, 2007.
DOI : 10.1128/IAI.00489-07

C. Chatfield, B. Mulhern, D. Burnside, and N. Cianciotto, Legionella pneumophila LbtU Acts as a Novel, TonB-Independent Receptor for the Legiobactin Siderophore, Journal of Bacteriology, vol.193, issue.7, pp.1563-1575, 2011.
DOI : 10.1128/JB.01111-10

C. Chatfield, B. Mulhern, V. Viswanathan, and N. Cianciotto, The major facilitator superfamily-type protein LbtC promotes the utilization of the legiobactin siderophore by Legionella pneumophila, Microbiology, vol.158, issue.Pt_3, pp.721-735, 2012.
DOI : 10.1099/mic.0.055533-0

M. Chien, I. Morozova, S. Shi, H. Sheng, J. Chen et al., The Genomic Sequence of the Accidental Pathogen Legionella pneumophila, Science, vol.305, issue.5692, pp.1966-1968, 2004.
DOI : 10.1126/science.1099776

N. Cianciotto, Iron Acquisition by Legionella pneumophila, BioMetals, vol.70, issue.3-4, pp.323-331, 2007.
DOI : 10.1007/s10534-006-9057-4

S. Cirillo, J. Lum, and J. Cirillo, Identification of novel loci involved in entry by Legionella pneumophila, Microbiology, vol.146, issue.6, pp.1345-1359, 2000.
DOI : 10.1099/00221287-146-6-1345

Z. Dalebroux and M. Swanson, ppGpp: magic beyond RNA polymerase, Nature Reviews Microbiology, vol.71, issue.3, pp.203-212, 2012.
DOI : 10.1038/nrmicro2720

Z. Dalebroux, R. Edwards, and M. Swanson, differentiation in host macrophages, Molecular Microbiology, vol.5, issue.3, pp.640-658, 2009.
DOI : 10.1111/j.1365-2958.2008.06555.x

P. Declerck, J. Behets, V. Van-hoef, and F. Ollevier, Replication of Legionella pneumophila in Floating Biofilms, Current Microbiology, vol.39, issue.14, pp.435-440, 2007.
DOI : 10.1007/s00284-007-9006-7

R. Edwards, Z. Dalebroux, and M. Swanson, couples fatty acid flux to microbial differentiation and virulence, Molecular Microbiology, vol.184, issue.5, pp.1190-1204, 2009.
DOI : 10.1111/j.1365-2958.2008.06593.x

L. Escolar, J. Perez-martin, and V. De-lorenzo, Opening the iron box: transcriptional metalloregulation by the Fur protein, J Bacteriol, vol.181, pp.6223-6229, 1999.

B. Fields, R. Benson, and R. Besser, Legionella and Legionnaires' Disease: 25 Years of Investigation, Clinical Microbiology Reviews, vol.15, issue.3, pp.506-526, 2002.
DOI : 10.1128/CMR.15.3.506-526.2002

E. Hickey and N. Cianciotto, Cloning and sequencing of the Legionella pneumophila fur gene, Gene, vol.143, issue.1, pp.117-121, 1994.
DOI : 10.1016/0378-1119(94)90615-7

E. Hickey and N. Cianciotto, An iron-and fur-repressed Legionella pneumophila gene that promotes intracellular infection and encodes a protein with similarity to the Escherichia coli aerobactin synthetases, Infect Immun, vol.65, pp.133-143, 1997.

L. Huang, D. Boyd, W. Amyot, A. Hempstead, Z. Luo et al., The E Block motif is associated with Legionella pneumophila translocated substrates, Cellular Microbiology, vol.76, issue.2, pp.227-245, 2011.
DOI : 10.1111/j.1462-5822.2010.01531.x

M. Koide, A. Saito, N. Kusano, and F. Higa, Detection of Legionella spp. in cooling tower water by the polymerase chain reaction method, Appl Environ Microbiol, vol.59, pp.1943-1946, 1993.

J. Leong, J. Neilands, and R. Kn, Coordination isomers of biological iron transport compounds III. (1) transport of A-cis-chromic desferriferrichrome by Ustilago sphaerogena, Biochemical and Biophysical Research Communications, vol.60, issue.3, pp.1066-1071, 1974.
DOI : 10.1016/0006-291X(74)90421-5

M. Liles, T. Scheel, and N. Cianciotto, Discovery of a Nonclassical Siderophore, Legiobactin, Produced by Strains of Legionella pneumophila, Journal of Bacteriology, vol.182, issue.3, pp.749-757, 2000.
DOI : 10.1128/JB.182.3.749-757.2000

K. Livak and T. Schmittgen, Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2???????CT Method, Methods, vol.25, issue.4, pp.402-408, 2001.
DOI : 10.1006/meth.2001.1262

D. Dervins-ravault, R. M. Nora, T. Newton, H. Sansom, and F. , The Legionella pneumophila F-box protein Lpp2082 (AnkB) modulates ubiquitination of the host protein parvin B and promotes intracellular replication, Cell Microbiol, vol.12, pp.1272-1291, 2010.

L. Magnusson, A. Farewell, and T. Nystrom, ppGpp: a global regulator in Escherichia coli, Trends in Microbiology, vol.13, issue.5, pp.236-242, 2005.
DOI : 10.1016/j.tim.2005.03.008

A. Molofsky and M. Swanson, Differentiate to thrive: lessons from the Legionella pneumophila life cycle, Molecular Microbiology, vol.184, issue.1, pp.29-40, 2004.
DOI : 10.1111/j.1365-2958.2004.04129.x

B. Py and F. Barras, Building Fe???S proteins: bacterial strategies, Nature Reviews Microbiology, vol.28, issue.6, pp.436-446, 2010.
DOI : 10.1038/nrmicro2356

C. Ratledge and L. Dover, Iron Metabolism in Pathogenic Bacteria, Annual Review of Microbiology, vol.54, issue.1, pp.881-941, 2000.
DOI : 10.1146/annurev.micro.54.1.881

M. Reeves, L. Pine, J. Neilands, and A. Balows, Absence of siderophore activity in Legionella species grown in iron-deficient media, J Bacteriol, vol.154, pp.324-329, 1983.

M. Reeves, L. Pine, S. Hutner, J. George, and W. Harrell, Metal requirements of Legionella pneumophila, J Clin Microbiol, vol.13, pp.688-695, 1981.

J. Riemer, H. Hoepken, H. Czerwinska, S. Robinson, and R. Dringen, Colorimetric ferrozine-based assay for the quantitation of iron in cultured cells, Analytical Biochemistry, vol.331, issue.2, pp.370-375, 2004.
DOI : 10.1016/j.ab.2004.03.049

M. Robey and N. Cianciotto, Legionella pneumophila feoAB Promotes Ferrous Iron Uptake and Intracellular Infection, Infection and Immunity, vol.70, issue.10, pp.5659-5669, 2002.
DOI : 10.1128/IAI.70.10.5659-5669.2002

B. Roche, L. Aussel, B. Ezraty, P. Mandin, B. Py et al., Iron/sulfur proteins biogenesis in prokaryotes: Formation, regulation and diversity, Biochimica et Biophysica Acta (BBA) - Bioenergetics, vol.1827, issue.3, pp.455-469, 2013.
DOI : 10.1016/j.bbabio.2012.12.010

M. Rolando, S. Sanulli, C. Rusniok, L. Gomez-valero, C. Bertholet et al., Legionella pneumophila Effector RomA Uniquely Modifies Host Chromatin to Repress Gene Expression and Promote Intracellular Bacterial Replication, Cell Host & Microbe, vol.13, issue.4, pp.395-405, 2013.
DOI : 10.1016/j.chom.2013.03.004

URL : https://hal.archives-ouvertes.fr/pasteur-01336636

T. Rowbotham, Preliminary report on the pathogenicity of Legionella pneumophila for freshwater and soil amoebae., Journal of Clinical Pathology, vol.33, issue.12, pp.1179-1183, 1980.
DOI : 10.1136/jcp.33.12.1179

T. Sahr, C. Rusniok, D. Dervins-ravault, O. Sismeiro, J. Coppee et al., and identifies growth phase-dependent regulated ncRNAs implicated in virulence, RNA Biology, vol.9, issue.4, pp.503-519, 2012.
DOI : 10.4161/rna.20270

URL : https://hal.archives-ouvertes.fr/pasteur-01338351

U. Schaible and S. Kaufmann, Iron and microbial infection, Nature Reviews Microbiology, vol.72, issue.12, pp.946-953, 2004.
DOI : 10.1172/JCI200420945

M. Steinert, U. Hentschel, and J. Hacker, : an aquatic microbe goes astray, FEMS Microbiology Reviews, vol.26, issue.2, pp.149-162, 2002.
DOI : 10.1111/j.1574-6976.2002.tb00607.x

D. Vinella, C. Albrecht, M. Cashel, D. Ari, and R. , Iron limitation induces SpoT-dependent accumulation of ppGpp in Escherichia coli, Molecular Microbiology, vol.56, issue.Suppl. B, pp.958-970, 2005.
DOI : 10.1111/j.1365-2958.2005.04601.x

URL : https://hal.archives-ouvertes.fr/hal-00069437

V. Viswanathan, P. Edelstein, C. Pope, and N. Cianciotto, The Legionella pneumophila iraAB Locus Is Required for Iron Assimilation, Intracellular Infection, and Virulence, Infection and Immunity, vol.68, issue.3, pp.1069-1079, 2000.
DOI : 10.1128/IAI.68.3.1069-1079.2000

E. Weinberg, Iron and infection, Microbiol Rev, vol.42, pp.45-66, 1978.

H. Zheng, C. Chatfield, M. Liles, and N. Cianciotto, Secreted Pyomelanin of Legionella pneumophila Promotes Bacterial Iron Uptake and Growth under Iron-Limiting Conditions, Infection and Immunity, vol.81, issue.11, pp.4182-4191, 2013.
DOI : 10.1128/IAI.00858-13