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The genetic basis for susceptibility to Rift Valley fever disease in MBT/Pas mice.: Host genetic control of Rift Valley fever disease

Abstract : The large variation in individual response to infection with Rift Valley fever virus (RVFV) suggests that host genetic determinants play a role in determining virus-induced disease outcomes. These genetic factors are still unknown. The systemic inoculation of mice with RVFV reproduces major pathological features of severe human disease, notably the hepatitis and encephalitis. A genome scan performed on 546 (BALB/c × MBT) F2 progeny identified three quantitative trait loci (QTLs), denoted Rvfs-1 to Rvfs-3, that were associated with disease susceptibility in MBT/Pas mice. Non-parametric interval-mapping revealed one significant and two suggestive linkages with survival time on chromosomes 2 (Rvfs-1), 5 (Rvfs-3) and 11 (Rvfs-2) with respective logarithm of odds (LOD) scores of 4.58, 2.95 and 2.99. The two-part model, combining survival time and survival/death, identified one significant linkage to Rvfs-2 and one suggestive linkage to Rvfs-1 with respective LOD scores of 5.12 and 4.55. Under a multiple model, with additive effects and sex as a covariate, the three QTLs explained 8.3% of the phenotypic variance. Sex had the strongest influence on susceptibility. The contribution of Rvfs-1, Rvfs-2 and Rvfs-3 to survival time of RVFV-infected mice was further confirmed in congenic mice.
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S Tokuda, T Z Do Valle, L Batista, D Simon-Chazottes, L Guillemot, et al.. The genetic basis for susceptibility to Rift Valley fever disease in MBT/Pas mice.: Host genetic control of Rift Valley fever disease. Genes and Immunity, Nature Publishing Group: Open Access Hybrid Model Option B, 2015, 16 (3), pp.206-12. ⟨10.1038/gene.2014.79⟩. ⟨pasteur-01325818⟩

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