Skip to Main content Skip to Navigation
Journal articles

No evidence for local adaptation of dengue viruses to mosquito vector populations in Thailand

Abstract : Despite their epidemiological importance, the evolutionary forces that shape the spatial structure of dengue virus genetic diversity are not fully understood. Fine-scale genetic structure of mosquito vector populations and evidence for genotype 9 genotype interactions between dengue viruses and their mosquito vectors are consistent with the hypothesis that the geographical distribution of dengue virus genetic diversity may reflect viral adaptation to local mosquito populations. To test this hypothesis, we measured vector competence in all sympatric and allo-patric combinations of 14 low-passage dengue virus isolates and two wild-type populations of Aedes aegypti mosquitoes sampled in Bangkok and Kamphaeng Phet, two sites located about 300 km apart in Thailand. Despite significant genotype 9 genotype interactions, we found no evidence for superior vector competence in sympatric versus allopatric vector–virus combinations. Viral phylogenetic analysis revealed no geographical clustering of the 14 isolates, suggesting that high levels of viral migration (gene flow) in Thailand may counteract spatially heterogeneous natural selection. We conclude that it is unlikely that vector mediated selection is a major driver of dengue virus adaptive evolution at the regional scale that we examined. Dengue virus local adaptation to mosquito vector populations could happen, however, in places or times that we did not test, or at a different geographical scale.
Document type :
Journal articles
Complete list of metadatas

Cited literature [48 references]  Display  Hide  Download

https://hal-pasteur.archives-ouvertes.fr/pasteur-01316117
Contributor : Louis Lambrechts <>
Submitted on : Saturday, May 14, 2016 - 11:05:19 PM
Last modification on : Monday, March 9, 2020 - 1:40:05 PM
Long-term archiving on: : Tuesday, August 16, 2016 - 10:15:19 AM

File

Fansiri_et_al-2016-Evolutionar...
Publication funded by an institution

Licence


Distributed under a Creative Commons Attribution 4.0 International License

Identifiers

Collections

Citation

Thanyalak Fansiri, Arissara Pongsiri, Chonticha Klungthong, Alongkot Ponlawat, Butsaya Thaisomboonsuk, et al.. No evidence for local adaptation of dengue viruses to mosquito vector populations in Thailand. Evolutionary Applications, Blackwell, 2016, 9 (4), pp.608-618. ⟨10.1111/eva.12360⟩. ⟨pasteur-01316117⟩

Share

Metrics

Record views

481

Files downloads

671