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Journal articles
Activation of adult-born neurons facilitates learning and memory
Abstract : Thousand of local interneurons reach the olfactory bulb of adult rodents every day, but the functional effect of this process
remains elusive. By selectively expressing channelrhodopsin in postnatal-born mouse neurons, we found that their activation
accelerated difficult odor discrimination learning and improved memory. This amelioration was seen when photoactivation
occurred simultaneously with odor presentation, but not when odor delivery lagged by 500 ms. In addition, learning was
facilitated when light flashes were delivered at 40 Hz, but not at 10 Hz. Both in vitroand in vivoelectrophysiological recordings
of mitral cells revealed that 40-Hz stimuli produced enhanced GABAergic inhibition compared with 10-Hz stimulation.
Facilitation of learning occurred specifically when photoactivated neurons were generated during adulthood. Taken together,
our results demonstrate an immediate causal relationship between the activity of adult-born neurons and the function of the
olfactory bulb circuit.
Cited literature [48 references]
https://hal-pasteur.archives-ouvertes.fr/pasteur-01309034
Contributor : Mariana Alonso <>
Submitted on : Thursday, April 28, 2016 - 5:52:08 PM
Last modification on : Wednesday, December 2, 2020 - 10:04:02 AM
Contributor : Mariana Alonso <>
Submitted on : Thursday, April 28, 2016 - 5:52:08 PM
Last modification on : Wednesday, December 2, 2020 - 10:04:02 AM