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Elongation of the axoneme and dynamics of intraflagellar transport

Abstract : Cilia and flagella are essential organelles in most eukaryotes including human beings. In this review, we will discuss the mode of assembly of these complex organelles that depends on a dynamic process called intraflagellar transport or IFT. IFT delivers structural elements at the distal end of the cilium where assembly takes place, thereby allowing the growth of the organelle. We next discuss the different models for control of cilium length and their alterations in ciliopathies, genetic diseases associated to ciliary defects.
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Cécile Fort, Philippe Bastin. Elongation of the axoneme and dynamics of intraflagellar transport. médecine/sciences, EDP Sciences, 2014, 30 (11), pp.955-961. ⟨10.1051/medsci/20143011008⟩. ⟨pasteur-01301213⟩

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