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Journal articles
Epidemiologically and clinically relevant Group B Streptococcus isolates do not bind collagen but display enhanced binding to human fibrinogen.
Abstract : Group B Streptococcus (GBS) is the leading cause of neonatal septicemia and meningitis. Pili appendages were shown to play a critical role in bacterial adhesion and colonization of human tissues. Recently it was claimed that binding of the pilus-associated adhesin PilA to collagen is a critical, initial step in promoting interactions with the α2β1 integrin expressed on brain endothelial cells. Here we show that strain NCTC10/84 used in this study is not representative for GBS isolates and question the importance of collagen as a critical extracellular matrix component for GBS infections of the central nervous system.
Cited literature [18 references]
https://hal-pasteur.archives-ouvertes.fr/pasteur-01300174
Contributor : Anne Lassailly-Bondaz <>
Submitted on : Friday, April 8, 2016 - 5:53:11 PM
Last modification on : Tuesday, December 8, 2020 - 10:16:17 AM
Long-term archiving on: : Tuesday, November 15, 2016 - 12:10:42 AM
Contributor : Anne Lassailly-Bondaz <>
Submitted on : Friday, April 8, 2016 - 5:53:11 PM
Last modification on : Tuesday, December 8, 2020 - 10:16:17 AM
Long-term archiving on: : Tuesday, November 15, 2016 - 12:10:42 AM