The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice, Nature, vol.77, issue.6046, pp.533-538, 1985. ,
DOI : 10.1038/318533a0
Disabling Immune Tolerance by Programmed Death-1 Blockade With Pidilizumab After Autologous Hematopoietic Stem-Cell Transplantation for Diffuse Large B-Cell Lymphoma: Results of an International Phase II Trial, Journal of Clinical Oncology, vol.31, issue.33, 2013. ,
DOI : 10.1200/JCO.2012.48.3685
Alloantigen expression on non-hematopoietic cells reduces graft-versus-leukemia effects in mice, Journal of Clinical Investigation, vol.120, issue.7, pp.2370-2378, 2010. ,
DOI : 10.1172/JCI39165
Langerhans cells regulate cutaneous injury by licensing CD8 effector cells recruited to the skin, Blood, vol.117, issue.26, pp.7063-7069, 2011. ,
DOI : 10.1182/blood-2011-01-329185
Blockade of programmed death-1 engagement accelerates graft-versus-host disease lethality by an IFN-gamma-dependent mechanism, J, 2003. ,
A Role for CD40 Expression on CD8+ T Cells in the Generation of CD8+ T Cell Memory, Science, vol.297, issue.5589, pp.2060-2063, 2002. ,
DOI : 10.1126/science.1072615
Phase I study of singleagent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical specific for the programmed death-1 homolog prevents graft-versus-host disease in mouse models, J. Immunol. Baltim. Md, vol.187, pp.1537-1541, 1950. ,
Nonhematopoietic antigen blocks memory programming of alloreactive CD8+ T cells and drives their eventual exhaustion in mouse models of bone marrow transplantation, Journal of Clinical Investigation, vol.120, issue.11, pp.3855-3868, 2010. ,
DOI : 10.1172/JCI41446DS1
Y-antigen killing by T cells of women is restricted by HLA, Nature, vol.4, issue.5602, pp.544-545, 1977. ,
DOI : 10.1038/262795a0
Mismatches of Minor Histocompatibility Antigens between HLA-Identical Donors and Recipients and the Development of Graft-Versus-Host Disease after Bone Marrow Transplantation, New England Journal of Medicine, vol.334, issue.5, pp.281-285, 1996. ,
DOI : 10.1056/NEJM199602013340501
Quantitative and qualitative differences in use and trends of hematopoietic stem cell transplantation: a Global Observational Study, Haematologica, vol.98, issue.8, pp.1282-1290, 2013. ,
DOI : 10.3324/haematol.2012.076349
L-selectin-negative CCR7??? effector and memory CD8+ T cells enter reactive lymph nodes and kill dendritic cells, Nature Immunology, vol.440, issue.7, 2007. ,
DOI : 10.1038/ni1469
Safety and Tumor Responses with Lambrolizumab (Anti???PD-1) in Melanoma, New England Journal of Medicine, vol.369, issue.2, pp.134-144, 2013. ,
DOI : 10.1056/NEJMoa1305133
Extramedullary relapse of acute myeloid leukemia following allogeneic hematopoietic stem cell transplantation: incidence, risk factors and outcomes, Haematologica, vol.98, pp.179-184, 2013. ,
Tuning of Antigen Sensitivity by T Cell Receptor-Dependent Negative Feedback Controls T Cell Effector Function in Inflamed Tissues, Immunity, vol.40, issue.2, pp.235-247, 2014. ,
DOI : 10.1016/j.immuni.2013.11.017
T cell effector activities in situ are regulated by target cell type, The Journal of Experimental Medicine, vol.154, issue.1, pp.167-180, 2011. ,
DOI : 10.1016/S0002-9440(10)63950-8
T cells activated locally within the transplanted liver, The Journal of Experimental Medicine, vol.52, issue.2, pp.437-447, 2006. ,
DOI : 10.4049/jimmunol.172.9.5222
PD-L1 blockade effectively restores strong graft-versus-leukemia effects without graft-versus-host disease after delayed adoptive transfer of T-cell receptor gene-engineered allogeneic CD8+ T cells, Blood, vol.117, issue.3, pp.1030-1041, 2011. ,
DOI : 10.1182/blood-2010-04-283119
In vivo equilibrium of proinflammatory IL- 17+ and regulatory IL-10+ Foxp3+ RORgamma t+ T cells, J. Exp. Med, vol.205, pp.1381-1393, 2008. ,
URL : https://hal.archives-ouvertes.fr/pasteur-00509619
Distinct APC subtypes drive spatially segregated CD4+ and CD8+ T-cell effector activity during skin infection with HSV-1, PLoS Pathog, vol.10, 2014. ,
Graft-versus-Leukemia (GVL) against Mouse Blast-Crisis Chronic Myelogenous Leukemia (BC-CML) and Chronic-Phase Chronic Myelogenous Leukemia (CP-CML): Shared Mechanisms of T Cell Killing, but Programmed Death Ligands Render CP-CML and Not BC-CML GVL Resistant, The Journal of Immunology, vol.187, issue.4, 2011. ,
DOI : 10.4049/jimmunol.1100311
Regulatory T cells reversibly suppress cytotoxic T cell function independent of effector differentiation, Immunity, vol.25, pp.129-141, 2006. ,
Antibody responses to H-Y minor histocompatibility antigens correlate with chronic graft-versus-host disease and disease remission, Blood, vol.105, pp.2973-2978, 2005. ,
Allogeneic HY antibodies detected 3 months after female to male sex-mismatched HCT predict chronic GVHD and non-relapse mortality, Blood, 2015. ,
PD-1/PD-L1 Interactions Contribute to Functional T-Cell Impairment in Patients Who Relapse with Cancer After Allogeneic Stem Cell Transplantation, Cancer Research, vol.71, issue.15, pp.5111-5122, 2011. ,
DOI : 10.1158/0008-5472.CAN-11-0108
2013 report from the Center for International Blood and Marrow Transplant Research (CIBMTR): current uses and outcomes of hematopoietic cell transplants for blood and bone marrow disorders, 2013. ,
A Revision of Billingham???s Tenets: The Central Role of Lymphocyte Migration in Acute Graft-versus-Host Disease, Biology of Blood and Marrow Transplantation, vol.12, issue.1, p.27, 2006. ,
DOI : 10.1016/j.bbmt.2005.09.015
Host programmed death ligand 1 is dominant over programmed death ligand 2 expression in regulating graft-versus-host disease lethality, Blood, vol.122, issue.17, pp.3062-3073, 2013. ,
DOI : 10.1182/blood-2013-05-500801
PD-1???PD-L1 Pathway Is Involved in Suppressing Alloreactivity of Heart Infiltrating T Cells During Murine GVHD Across Minor Histocompatibility Antigen Barriers, Transplantation, vol.84, issue.2, pp.214-222, 2007. ,
DOI : 10.1097/01.tp.0000268074.77929.54
Regulatory T cells and natural killer T cells for modulation of GVHD following allogeneic hematopoietic cell transplantation, Blood, vol.122, issue.18, pp.3116-3121, 2013. ,
DOI : 10.1182/blood-2013-08-453126
Role of Lymphocyte Activation Gene-3 (Lag-3) in Conventional and Regulatory T Cell Function in Allogeneic Transplantation, PLoS ONE, vol.186, issue.1, p.86551, 2014. ,
DOI : 10.1371/journal.pone.0086551.g007
Minor Antigen Distribution Predicts Site-Specific Graft-versus-Tumor Activity of Adoptively Transferred, Minor Antigen-Specific CD8 T Cells, Biology of Blood and Marrow Transplantation, vol.20, issue.1, pp.26-36, 2014. ,
DOI : 10.1016/j.bbmt.2013.10.009
Prevalence of extramedullary relapses is higher after allogeneic stem cell transplantation than after chemotherapy in adult patients with acute myeloid leukemia, Leukemia Research, vol.37, issue.11, pp.1477-1481, 2013. ,
DOI : 10.1016/j.leukres.2013.08.017
Lymphatic endothelial cells induce 28, 2012. ,
Immune tolerance: What is unique about the liver, Journal of Autoimmunity, vol.34, issue.1, 2010. ,
DOI : 10.1016/j.jaut.2009.08.008
Induction of acute GVHD by sex-mismatched H-Y antigens in the absence of functional radiosensitive host hematopoietic-derived antigen-presenting cells, Blood, vol.119, issue.16, pp.3844-3853, 2012. ,
DOI : 10.1182/blood-2011-10-384057
Cross-primed CD8+ T cells mediate graft rejection via a distinct effector pathway, Nature Immunology, vol.3, issue.9, pp.844-851, 2002. ,
DOI : 10.1038/ni831
Contrasting acute graft-versus-host disease effects of Tim-3/galectin-9 pathway blockade dependent upon the presence of donor regulatory T cells, Blood, vol.120, issue.3, pp.682-690, 2012. ,
DOI : 10.1182/blood-2011-10-387977
Next-generation leukemia immunotherapy, Blood, vol.118, issue.11, pp.2951-2959, 2011. ,
DOI : 10.1182/blood-2011-04-350868
Graft-versus-host disease is enhanced by extracellular ATP activating P2X7R, Nature Medicine, vol.16, issue.12, pp.1434-1438, 2010. ,
DOI : 10.1038/nm.2242
PD-1 promotes immune exhaustion by inducing antiviral T cell motility paralysis, The Journal of Experimental Medicine, vol.121, issue.4, pp.757-774, 2013. ,
DOI : 10.1016/S0076-6879(09)05416-0